My laboratory uses structural biology in combination with biochemical approaches to study the structure and function of mitochondrial transcription machinery. We are interested in deciphering molecular mechanisms of transcription initiation, elongation, termination and anti-termination, as well as replication primer synthesis by mitochondrial RNA polymerase. We also aim to understand the interplay between transcription and replication machineries in mitochondria of normal and cancer cells.
Dmitry Temiakov, PhD
Professor, Department of Biochemistry & Molecular Biology
Contact Information
1020 Locust Street
Jefferson Alumni Hall, Room 425E
Philadelphia, PA 19107
Professor, Department of Biochemistry & Molecular Biology
Expertise and Research Interests
Publications
- Structural basis for intrinsic strand displacement activity of mitochondrial DNA polymerase
- Maackia amurensis seed lectin structure and sequence comparison with other M. amurensis lectins
- Reply to: An alternative model for maternal mtDNA inheritance
- Structural basis for substrate binding and selection by human mitochondrial RNA polymerase
- Structural basis for DNA proofreading