Dmitry Temiakov, PhD
Associate Professor, Department of Biochemistry & Molecular Biology

Contact
1020 Locust Street
Jefferson Alumni Hall, Room 425E
Philadelphia, PA 19107
Featured Links
Dmitry Temiakov, PhD
Associate Professor, Department of Biochemistry & Molecular Biology
Expertise and Research Interests
My laboratory uses structural biology in combination with biochemical approaches to study the structure and function of mitochondrial transcription machinery. We are interested in deciphering molecular mechanisms of transcription initiation, elongation, termination and anti-termination, as well as replication primer synthesis by mitochondrial RNA polymerase. We also aim to understand the interplay between transcription and replication machineries in mitochondria of normal and cancer cells.
Publications
- Molecular basis for maternal inheritance of human mitochondrial DNA
- Mesoscale structure–function relationships in mitochondrial transcriptional condensates
- Mechanisms of mitochondrial promoter recognition in humans and other mammalian species
- Mechanism of transcription initiation and primer generation at the mitochondrial replication origin OriL
- The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs