The main goal of my research is to discover an efficient way to get clinically applicable dopaminergic (DA) neurons differentiated from stem cells, such as human embryonic stem cells or induced pluripotent stem cells. We have been investigating fate decision genes and profiling lineage stages of DA differentiation. By studying the differentiation mechanism, we hope to find an abundant source of cells capable of DAergic function in the brain to replace degenerated DA neurons in Parkinson disease patients.
Jingli Cai, PhD
Research Instructor, Iacovitti Laboratory
Vickie & Jack Farber Institute for Neuroscience
Contact Information
900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107
215-955-5363
215-503-4358 fax
Research Instructor, Iacovitti Laboratory
Vickie & Jack Farber Institute for Neuroscience
Research & Clinical Interests
Publications
- A stress-free strategy to correct point mutations in patient iPS cells
- Subregional differences in astrocytes underlie selective neurodegeneration or protection in Parkinson's disease models in culture
- Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model
- Systemic Factors Trigger Vasculature Cells to Drive Notch Signaling and Neurogenesis in Neural Stem Cells in the Adult Brain
- The versatility of RhoA activities in neural differentiation