The research in my laboratory focuses on voltage-gated potassium channels (Kv channels) expressed in the nervous system and the heart. We investigate the molecular mechanisms governing the function and regulation of these ion channels. In particular, we focus on: 1) inactivation gating of Kv channels and its modulation by auxiliary subunits and signaling cascades; 2) structural mapping of inhaled anesthetic/alcohol sites; and 3) functional impact of A-type potassium currents in dorsal root ganglion neurons. These studies can impact our understanding of neuronal plasticity, epilepsy, pain, autism, arrhythmias, anesthesia and alcohol intoxication. Furthermore, they may reveal potential drug-targets. The research platform of our work is based on a modern multidisciplinary approach, which combines electrophysiology, molecular biology, biochemistry, pharmacology and mathematical modeling.
Manuel L. Covarrubias, MD, PhD
Professor, Department of Neuroscience
Vickie & Jack Farber Institute for Neuroscience
Contact Information

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107
215-503-4340
215-503-4358 fax
Professor, Department of Neuroscience
Vickie & Jack Farber Institute for Neuroscience
Research & Clinical Interests
Publications
- Structural insights into the function, dysfunction and modulation of Kv3 channels
- Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons
- The binding and mechanism of a positive allosteric modulator of Kv3 channels
- Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy
- A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction