Margaret A. Keller, PhD
Executive Director, National Laboratories, American Red Cross Philadelphia, PA
Margaret A. Keller, PhD
Executive Director, National Laboratories, American Red Cross Philadelphia, PA
Research & Clinical Interests
Dr. Margaret A. Keller is the Executive Director, National Laboratories, American Red Cross, Philadelphia, PA. The National Molecular Laboratory at the American Red Cross provides DNA-based testing for blood group and platelet antigens. The laboratory screens selected blood donors to identify those with rare blood types or those negative for multiple antigens. Such donors are eligible for entry into the American Rare Donor Program and help support the needs of patients with antibodies to blood group antigens. The laboratory also performs DNA-based-testing of patient samples to predict antigen status. This is useful in cases where serologic phenotype is not possible due to recent transfusion, positive direct antiglobulin test or lack of serologic reagents. Testing is also useful if the patient is suspected of having a variant antigen, as is common in the Rh system in individuals of African descent. DNA-based testing includes the use of medium throughput, multianalyte tests such as BeadChip (BioArray Solutions) as well as lab-developed tests and DNA sequence analysis. Dr. Keller is a member of the Molecular Standards committee of the AABB.
Red Cell Immunohematology
Blood Group and Platelet Antigen Genotyping
Blood Group Antigen Alloimmunization
Sickle Cell Disease Transfusion Management
Personalized Medicine Research
Education
PhD, University of Pennsylvania, Molecular Genetics - 1994
BA, Rutgers College, Rutgers University, Biochemistry - 1988
Publications
- P-IG-39 | RHD*DEL44 [RHD-CE(4-9)-D] is Associated with Lack of RhD Antigen and Expression of Altered C Antigen
- P-BB-42 | IgA-deficient Donors—Screening Process and Data from Three US Centers
- Update on programs for achieving Specialist in Blood Banking certification in the United States: 2023
- World human neutrophil antigens investigation survey
- RH genetic variation and the impact for typing and personalized transfusion strategies: a narrative review
- To contributors to the 2022 issues
- International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and three virtual business meetings: Update on blood group systems
- Novel KEL allele associated with loss of Kpbidentified in a white blood donor
- New ABO intron 1 variant alleles
- Development of anti-Jk3 associated with silenced Kidd antigen expression and a novel single nucleotide variant of the JK gene
- Change in Command for Immunohematology
- It's time to phase out “serologic weak D phenotype” and resolve D types with RHD genotyping including weak D type 4
- Identifying obstetrics patients in whom rhd genotyping can be used to assess risk of d alloimmunization
- An update on the RAPH blood group system
- Comparison of ABO genotyping methods: A study of two low-resolution polymerase chain reaction assays in a clinical testing laboratory
- Banking with precision: Transfusion medicine as a potential universal application in clinical genomics
- Validated Reference Panel from Renewable Source of Genomic DNA Available for Standardization of Blood Group Genotyping
- Experience with RHD*weak D type 4.0 in the USA
- International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology: Report of the Dubai, Copenhagen and Toronto meetings
- RH genotype matching for transfusion support in sickle cell disease