My laboratory seeks to understand the regulation of lymphocyte recirculation as well as the microenvironmental localization of different effector and memory lymphocytes within extralymphoid tissues, especially the skin. It is our long-term goal to advance understanding of T and B cell recirculation and migration pathways leading to novel approaches to manipulate tissue infiltrates. This knowledge will give us the tools to moderate inflammation in inflammatory and autoimmune diseases and to enhance organ-specific immunity.