Structural biology, x-ray crystallography, chromatin, epigenetics, gene regulation, bromodomain, chromatin modifying enzymes, parasitology, trypanosomes, sleeping sickness, chemical biology, drug discovery.
Erik Debler, PhD
Associate Professor, Department of Biochemistry & Molecular Biology
Contact Information
233 South 10th Street
Suite 804
Philadelphia, PA 19107
215-503-4596
215-923-2117 fax
Associate Professor, Department of Biochemistry & Molecular Biology
EXPERTISE & RESEARCH INTERESTS
Publications
- Two DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastids
- The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS
- Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules
- Structural enzymology of cholesterol biosynthesis and storage
- Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment