Dr. McKenzie directs two major research projects. The first project involves vascular biology, with a focus on immune-mediated thrombocytopenia and thrombosis syndromes. This work, done in collaboration with Dr. Michael Reilly, led to the first model of heparin-induced thrombocytopenia and thrombosis. New work on effects of elevated cholesterol and athrosclerosis on HITT, and on microparticles and tissue factor, is ongoing.
Steven E. McKenzie, MD, PhD
Professor of Medicine, Cardeza Foundation for Hematologic Research
Contact Information
Research Office
1020 Locust Street
Suite 394
Philadelphia, PA 19107
215-955-8544
215-955-9170 fax
Professor of Medicine, Cardeza Foundation for Hematologic Research
Research & Clinical Interests
Publications
- VLX-1005, but not argatroban, prevents ITAM-mediated platelet activation and heparin-induced thrombocytopenia
- Understanding how a highly prevalent GRK5 polymorphism affects platelets and enhances thrombotic risk
- Platelet-Associated microRNAs as Markers of Aspirin Response and Pregnancy Outcome in Pregnancies at High-Risk for Preeclampsia
- Heparin-induced thrombocytopenia immune complexes activate the inflammasome pathway in a complement-dependent manner
- Platelet defects in patients and mice with Ehlers-Danlos syndrome