Isidore Rigoutsos, PhD

Pattern discovery; motif discovery; regulatory motifs; microRNAs; miRNAs; piRNAs; microRNA and piRNA targeting; non-coding RNAs; RNAi; RNA interference; retrotransposons; cell process regulation; genomics; computational genetics; computational medicine; diagnostics; therapeutics; high-throughput sequencing analysis; microbial genomics; metagenomics; high performance computing.

• Short RNA regulators: the past, the present, the future, and implications for precision medicine and health disparities
• TRNA fragments show intertwining with mRNAs of specific repeat content and have links to disparities
• Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation
• Profiles of miRNA Isoforms and tRNA Fragments in Prostate Cancer
• Race disparities in the contribution of miRNA isoforms and tRNA-derived fragments to Triple-negative breast cancer
• Accurate profiling and quantification of tRNA fragments from RNA-Seq Data: A Vade Mecum for MINTmap
• MINTbase v2.0: A comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all the Cancer Genome Atlas projects
• Increasing cell density globally enhances the biogenesis of Piwi-interacting RNAs in Bombyx mori germ cells
• The biogenesis pathway of tRNA-derived piRNAs in Bombyx germ cells
• Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma
• An miRNA expression signature for the human colonic stem cell niche distinguishes malignant from normal epithelia
• Threshold-seq: A tool for determining the threshold in short RNA-seq datasets
• N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration
• YAMAT-seq: An efficient method for high-throughput sequencing of mature transfer RNAs
• Assessment of isomiR discrimination using commercial qPCR methods
• MINTmap: Fast and exhaustive profiling of nuclear and mitochondrial tRNA fragments from short RNA-seq data
• Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types
• Post-transcriptional regulation of BRCA2 through interactions with miR-19a and miR-19b
• MINTbase: A framework for the interactive exploration of mitochondrial and nuclear tRNA fragments
• Integrative Multi-omic Analysis of Human Platelet eQTLs Reveals Alternative Start Site in Mitofusin 2

• SKMC Profile
• Dr. Rigoutsos' Research Lab Site
• Computational Medicine Center