Michael R. Sperling, MD
Baldwin Keyes Professor, Neurology
Contact
900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107
215-955-1222
215-503-4358 fax
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Michael R. Sperling, MD
Baldwin Keyes Professor, Neurology
Research and Clinical Interests
Clinical epilepsy, EEG
The research program in the Jefferson Comprehensive Epilepsy Center is multifaceted, reflecting the interests of the ten faculty members in the center. We are investigating various aspects of epilepsy, including novel treatments, autonomic effects of seizures, electrophysiology of seizures, new approaches to neuroimaging, and developing improved methods of prognostication in epilepsy. Pharmacologic studies investigate the metabolic consequences of antiepileptic medication, with specific attention to serologic markers of vascular risk. Neuroimaging studies are exploring connections between different brain areas in epilepsy, cognitive organization, memory, and language function in epilepsy. Electrographic studies of seizures hope to improve methods for mapping seizure spread within the brain with the goal of defining abnormal circuitry in epilepsy. Autonomic studies investigate cardiac rhythm disturbances in epilepsy, with companion epidemiologic studies of mortality in epilepsy. Long-term outcome studies of epilepsy surgery explore the consequences of cortical resection for this condition in medical, cognitive, linguistic, and psychosocial domains.
The techniques used in our research are those used in clinical studies, including MRI, fMRI, EEG, metabolic and pharmacologic measures, and epidemiologic methods.
Publications
- Long-Term Home EEG Recording: Wearable and Implantable Devices
- Which terms should be used to describe medications used in the treatment of seizure disorders? An ILAE position paper
- The role of copy number variants in the genetic architecture of common familial epilepsies
- Pathological neurons generate ripples at the UP-DOWN transition disrupting information transfer
- Prediction tools and risk stratification in epilepsy surgery