Rajanikanth Vadigepalli, PhD
Professor, Department of Pathology & Genomic Medicine
Co-Director, Cell Biology & Regenerative Medicine PhD Program

Contact
1020 Locust Street
314 Alumni Hall
Philadelphia, PA 19107
215-955-0576
215-503-2636 fax
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Rajanikanth Vadigepalli, PhD
Professor, Department of Pathology & Genomic Medicine
Co-Director, Cell Biology & Regenerative Medicine PhD Program
Expertise & Research Interests
Work in Dr. Vadigepalli's lab is directed at understanding the regulatory network dynamics driving the cellular adaptive processes in mammalian pathophysiology. Though cross-disciplinary collaborative projects, we study signaling and gene regulatory networks in : central cardiorespiratory control circuits adversely adapted in hypertension, alcohol toxicity on liver repair and regeneration, and abnormal stem cell differentiation in the context of fetal alcohol spectrum disorders. We use computational modeling, systems engineering and bioinformatics approaches to complement high-throughout experimentation. Trainees in the lab have the opportunity to gain experience in the computational modeling and analysis including transcriptional profiling, genome-wide localization, and next generation sequencing approaches; and experimental methods for high-throughout validation of gene regulatory mechanisms.
Visit the Vadigepalli Laboratory
Education
PhD, University of Delaware, Chemical Engineering - 2001
BTech, Indian Institute of Technology Madras, Chemical Engineering - 1996
Publications
- Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control
- Conditional expression of endorepellin in the tumor vasculature attenuates breast cancer growth, angiogenesis and hyaluronan deposition
- Elucidating the Mechanisms of Dynamic and Robust Control of the Liver Homeostatic Renewal Process: Cell Network Modeling and Analysis
- Unpacking the multimodal, multi-scale data of the fast and slow lanes of the cardiac vagus through computational modelling
- Longitudinal ultrasound imaging and network modeling in rats reveal sex-dependent suppression of liver regeneration after resection in alcoholic liver disease