Our focus is the development of mammalian systems biology to study the multi-scale regulatory networks in the context of adaptation in central autonomic control circuits, dysfunction of cardio-respiratory regulation, alcoholic liver disease and liver repair, and stem cell differentiation. In order to study intra- and inter-cellular networks, we employ genomic and other "omic" technologies to acquire datasets suitable for analyses to identify variables and relationships that provide a basis for modeling and simulation of multi-scale system dynamics. We develop bioinformatics tools to improve our ability to derive networks, pathways and relationships subserving cellular processes. We bring principles of control and systems theory as well as probabilistic/statistical techniques to bear on the analysis of biological processes.

We seek funding as an Institute for interdisciplinary team oriented projects. Ongoing projects are funded by National Institute of General Medical Sciences, National Heart Lung and Blood Institute, and National Institute on Alcohol Abuse and Alcoholism.