Deepak Deshpande, PhD
Associate Professor
Contact
1020 Locust Street
Room 543B
Philadelphia, PA 19107
215-955-3305
215-503-5731 fax
Deepak Deshpande, PhD
Associate Professor
Education
PhD, College of Veterinary Medicine, University of Minnesota - 2004
MS, Veterinary College, University of Agricultural Sciences, Bangalore, India - 1997
DMV, Veterinary College, University of Agricultural Sciences, Bangalore, India - 1994
Publications
- Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma
- Reactive Oxygen Species Behaving Badly: Oxidized Phosphatidylcholines Corrupt Ca2 Signaling in Airway Smooth Muscle
- Crosstalk between diacylglycerol kinase and protein kinase A in the regulation of airway smooth muscle cell proliferation
- Diacylglycerol kinase zeta deficiency attenuates papain-induced type 2 airway inflammation
- Proteomics-Based Approach for Detailing the Allergenic Profile of Cannabis Chemotypes
University Appointment
Associate Professor
Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine
Professional Societies
American Thoracic Society
Research & Clinical Interests
My laboratory studies intracellular signaling regulating contraction, relaxation and proliferation of airway smooth muscle with particular emphasis on G protein coupled receptor mediated signaling. Current projects include understanding age-dependent changes in airway smooth muscle function (funded by NIA/NIH) and bitter taste receptor signaling in airway smooth muscle (funded by American Asthma Foundation). Airway smooth muscle is the principle contractile component of airways, and contraction and relaxation of ASM regulate airway diameter. Any alteration in ASM function results in bronchoconstriction and difficulty in breathing. Therefore, ASM acts as a primary therapeutic target in obstructive airway diseases such as asthma and COPD. Delineating novel receptors and signaling mechanisms that regulate ASM function would provide basis for developing newer and better drugs to treat asthma.