PhD, College of Veterinary Medicine, University of Minnesota - 2004
MS, Veterinary College, University of Agricultural Sciences, Bangalore, India - 1997
DMV, Veterinary College, University of Agricultural Sciences, Bangalore, India - 1994
Deepak Deshpande, PhD, DVM
Associate Professor, Division of Pulmonary & Critical Care, Department of Medicine
Contact Information
1020 Locust Street
Room 543B
Philadelphia, PA 19107
215-955-3305
215-503-5731 fax
Associate Professor, Division of Pulmonary & Critical Care, Department of Medicine
Education
Publications
- Agonist-specific conformational dynamics at the β2-adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation
- Ovarian Cancer G protein-coupled receptor-1 signaling bias dictates anti-contractile effect of benzodiazepines on airway smooth muscle
- Biased Orthosteric Agonism and Allosteric Modulation: Emerging Strategies for Developing New Class of β-Agonists for Obstructive Airway Diseases
- Spatiotemporal calcium signaling patterns underlying opposing effects of histamine and TAS2R agonists in airway smooth muscle
- A-Kinase–Anchoring Protein Subtypes Differentially Regulate GPCR Signaling and Function in Human Airway Smooth Muscle
Professional Societies
American Thoracic Society
Research & Clinical Interests
G protein-coupled receptors, airway smooth muscle, asthma, pharmacology of airway diseases, non-coding RNAs in lung diseases.
Project(s):
- Role of diacylglycerol kinase in airway smooth muscle functions
- Compartmentalized calcium signaling in airway smooth muscle cells
- Bitter taste receptors in lung
- Biased beta adrenergic receptor signaling and role in asthma pharmacology
- Role of tRNA-derived non-coding RNAs in airway functions and in asthma
- Function-selective ERK inhibitors and regulation of airway remodeling
- Retinoic acid signaling in airway cells
My laboratory studies intracellular signaling regulating contraction, relaxation and proliferation of airway smooth muscle with particular emphasis on G protein coupled receptor mediated signaling. Airway smooth muscle is the principle contractile component of airways, and contraction and relaxation of ASM regulate airway diameter. Any alteration in ASM function results in bronchoconstriction and difficulty in breathing. Therefore, ASM acts as a primary therapeutic target in obstructive airway diseases such as asthma and COPD. Delineating novel receptors and signaling mechanisms that regulate ASM function would provide basis for developing newer and better drugs to treat asthma.