The Jefferson Department of Neurology is one of 18 clinical departments in the Jefferson Medical College. 

The medical school, one of the oldest in the nation, was founded in 1824 and is part of Thomas Jefferson University, a medical and health sciences educational institution. Today the Jefferson Department of Neurology is a highly renowned and esteemed clinical and academic department in the region.

The department is based in Thomas Jefferson University Hospital, a 717-bed tertiary and quaternary care hospital in center city Philadelphia. It also services the Jefferson Hospital for Neurosciences and Methodist Hospital, part of the Jefferson Hospital system. Outpatient services are provided at the Jefferson Hospital for Neurosciences.

Professional staff within the department include 65 attendings, 30 residents and 16 fellows.