Division of Rheumatology
Leadership
- Director, Division of Rheumatology
- Director, Rheumatology Fellowship Program
- Magee Professor in Medicine
Contact
211 South Ninth Street
Suite 210
Philadelphia, PA 19107
- 215-955-2820
- 215-923-7885 (fax)
Research Activities
Kiriakidou Lab
microRNAs in Systemic Lupus Erythematosus
RNA interference (RNAi) operates as a mechanism of innate immunity in plants, drosophila and C. elegans and depends on double stranded RNA and proteins of the Argonaute family. RNAi, programmed by exogenous small RNAs, is a powerful tool for gene-specific studies. The microRNA pathway intersects with the RNAi pathway and regulates gene expression in plants and animals. Animal microRNAs bind directly to Argonaute proteins (Ago1-4), providing target specificity to the regulatory function of Ago complexes. Research in the Kiriakidou lab focused on the biology of animal Ago proteins by studying the expression, regulation and function of animal Agos in human and mouse cells, mouse models and in vitro systems.
MicroRNAs are involved in numerous biological processes, and their expression is differentially regulated in human disease. Systemic Lupus Erythematosus (SLE, lupus) is a prototype systemic autoimmune disease characterized by autoantibody production and tissue deposition of immune complexes. Immunopathology in lupus is characterized by aberrant B and T cell functions. We are studying the role of microRNAs in pathways contributing to disease-specific B and T cell phenotypes and organ damage in SLE using microRNA KO models and mouse lupus models (congenic and induced). We also use synthetic inhibitors for microRNA silencing in vivo, to complement our genetic studies and to investigate potential use of microRNA.
Lab Members
Barry Garchow, PhD
Recent Publications
- Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice
- Tofacitinib treatment for psoriatic skin lesions associated with Aicardi-Goutières syndrome 7/Singleton-Merten syndrome 1
- Lung Microbiome in Autoimmune-Associated Interstitial Lung Disease
- Nodular scleroderma: Characterization of a distinct clinical phenotype
- Two Decades since the Unequal Treatment Report: The State of Racial, Ethnic, and Socioeconomic Disparities in Elective Total Hip and Knee Replacement Use
- Palovarotene in fibrodysplasia ossificans progressiva: review and perspective
- A review of recent studies on the pathogenesis of Systemic Sclerosis: focus on fibrosis pathways
- Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD
- Impact of climate change on aerobiology, rhinitis, and allergen immunotherapy: Work Group Report from the Aerobiology, Rhinitis, Rhinosinusitis & Ocular Allergy, and Immunotherapy, Allergen Standardization & Allergy Diagnostics Committees of the American Academy of Allergy, Asthma & Immunology
- A systematic review of prevalence and predictors of depression in systemic sclerosis based on the CES-D, BDI, and PHQ- 9 self-assessment questionnaires
- Valemetostat monotherapy in patients with relapsed or refractory non-Hodgkin lymphoma: a first-in-human, multicentre, open-label, single-arm, phase 1 study
- Heart rate variability wrist-wearable biomarkers identify adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure
- Neighborhood Resources Associated with Psychological Trajectories and Neural Reactivity to Reward after Trauma
- Characterizing Long COVID in Children and Adolescents
- ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels
- Sex Differences in Response Inhibition–Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma
- Letter to the editor in response to article "Use of statins in patients with established idiopathic inflammatory myopathies"
- Histological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials
- Primary anastomosis with diverting loop ileostomy vs. Hartmann’s procedure for acute diverticulitis: what happens after discharge? Results of a nationwide analysis
- Efficacy and Safety of Thermal Ablation after Endoscopic Mucosal Resection: A Systematic Review and Network Meta-Analysis