Leadership
- Director, Division of Rheumatology
- Director, Rheumatology Fellowship Program
- Magee Professor in Medicine
Contact
211 South Ninth Street
Suite 210
Philadelphia, PA 19107
- 215-955-2820
- 215-923-7885 (fax)
Research Activities
Kiriakidou Lab
microRNAs in Systemic Lupus Erythematosus
RNA interference (RNAi) operates as a mechanism of innate immunity in plants, drosophila and C. elegans and depends on double stranded RNA and proteins of the Argonaute family. RNAi, programmed by exogenous small RNAs, is a powerful tool for gene-specific studies. The microRNA pathway intersects with the RNAi pathway and regulates gene expression in plants and animals. Animal microRNAs bind directly to Argonaute proteins (Ago1-4), providing target specificity to the regulatory function of Ago complexes. Research in the Kiriakidou lab focused on the biology of animal Ago proteins by studying the expression, regulation and function of animal Agos in human and mouse cells, mouse models and in vitro systems.
MicroRNAs are involved in numerous biological processes, and their expression is differentially regulated in human disease. Systemic Lupus Erythematosus (SLE, lupus) is a prototype systemic autoimmune disease characterized by autoantibody production and tissue deposition of immune complexes. Immunopathology in lupus is characterized by aberrant B and T cell functions. We are studying the role of microRNAs in pathways contributing to disease-specific B and T cell phenotypes and organ damage in SLE using microRNA KO models and mouse lupus models (congenic and induced). We also use synthetic inhibitors for microRNA silencing in vivo, to complement our genetic studies and to investigate potential use of microRNA.
Lab Members
Barry Garchow, PhD
Recent Publications
- Efficacy and Safety of Thermal Ablation after Endoscopic Mucosal Resection: A Systematic Review and Network Meta-Analysis
- Hypophysitis Secondary to Small Vessel ANCA Vasculitis Treated With Rituximab
- Core outcome measurement set for research and clinical practice in post-COVID-19 condition (long COVID) in children and young people: an international Delphi consensus study "PC-COS Children"
- Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Does the Impact of COVID-19 on Patients With Systemic Sclerosis Change Over Time?
- Low utilization of statins in patients with dermatomyositis/polymyositis and hyperlipidemia: a multicenter USA-based study (2013–2023)
- Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
- Cartilage-specific Sirt6 deficiency represses IGF-1 and enhances osteoarthritis severity in mice
- Pharmacological treatment of systemic sclerosis-associated interstitial lung disease: an updated review and current approach to patient care
- Systemic and Intracranial Outcomes With First-Line Nivolumab Plus Ipilimumab in Patients With Metastatic NSCLC and Baseline Brain Metastases From CheckMate 227 Part 1
- The unfinished agenda of communicable diseases among children and adolescents before the COVID-19 pandemic, 1990–2019: a systematic analysis of the Global Burden of Disease Study 2019
- Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium
- CCL24, CXCL9 and CXCL10 are increased in synovial fluid in patients with juvenile idiopathic arthritis requiring advanced treatment
- Apoptotic vesicles ameliorate lupus and arthritis via phosphatidylserine-mediated modulation of T cell receptor signaling
- Serum antibodies to peptidylarginine deiminase-4 in rheumatoid arthritis associated-interstitial lung disease are associated with decreased lung fibrosis and improved survival
- Otologic manifestations in the setting of seronegative small vessel vasculitis: A case report
- Apoptotic cell death in disease—Current understanding of the NCCD 2023
- Musculoskeletal manifestations of syphilis in adults: secondary syphilis presenting with ankle inflammatory arthritis and bone involvement with calvarial and sternal lesions. What the rheumatologist needs to know
- Prior differences in previous trauma exposure primarily drive the observed racial/ethnic differences in posttrauma depression and anxiety following a recent trauma
- Multinucleation resets human macrophages for specialized functions at the expense of their identity