MD/PhD Program

College

  • Center City Campus
  • Sidney Kimmel Medical College

Degree Earned

  • Doctorate

Program Length
8 years

Program Type

  • On Campus

Prerequisites
Baccalaureate degree 
Learn more

Leadership

Name: Scott A. Waldman, MD, PhD, FCP
Position: Director, MD/PhD Program

1020 Locust Street
Jefferson Alumni Hall, 368
Philadelphia, PA 19107-5244

Contact Number(s):

Leadership

Name: Manuel Covarrubias, MD, PhD
Position: Director, MD/PhD Program

233 South 10th Street
Bluemle Life Sciences Building, 221A
Philadelphia, PA 19107

Contact Number(s):

Program Information

Name: Danielle Park
Position: Administrative Director
Contact Number(s):

Meet Our Current Students

Undergrad   Villanova University, BSH, BS, BA, 2014
Year   MD/PhD 8, JeffMD Phase 3, SKMC 4
Mentor   Ulhas Naik, PhD
PhD Program   Cell Biology & Regenerative Medicine
Research Interests   Our lab overall focuses on the role of platelets in cardiovascular disease. More specifically, I’m investigating the role of platelets in stroke and remote organ injury.
Hobbies/Interests   Global Health (Co-founded Breath for Humanity covid relief initiative with my mother; https://breathforhumanity.wordpress.com/blog/), Volunteering at the pediatric department, spending time with family and friends, reading, making no-bake desserts
Favorite Places/Things
to Do in Philadelphia
  Museum hopping/visiting the amazing historical landmarks scattered around the city; Having brunch with friends.
Honors/Awards  

National Pathology Honor Society (2016)

Hobart Amory Hare Medical Honor Society (2016)

Sigma Xi Post Award (2018)

JCBS Alumni Association Travel Fellowship Award (2018)

Gordon Research Seminar Best Hemostasis Presentation (2018)

1st Place Oral Presentation, Philadelphia Workshop on Hemostasis, Thrombosis, and Atherosclerosis (2018)

Outstanding Talk by a Jonathan Epstein Scholar (2021)

 Publications  

Iosue, C. L., Attanasio, N., Shaik, N. F., Wykoff, D. D. (2016). Partial Decay of Thiamine Signal Transduction Pathway Alters Growth Properties of Candida glabrataPLoS ONE, 11(3). PMC4807840. (Undergraduate)

Nahas, J.V., Iosue, C. L., Shaik, N. F., and Wykoff, D. D. (2018) Dynamic Changes in Yeast Phosphatase Families Allow for Specialization in Phosphate and Thiamine Starvation. G3 (Bethesda), Epub. PMID: 29748198 (Undergraduate)

Malherbe D., Kurup D., Wirblich C., Ronk A., Mire C., Kuzmina N., Shaik N., Periasamy S., Hyde M., Williams J., Shi P., Schnell M., and Bukreyev A. A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a model of severe COVID-19. Accepted to NPJ Vaccines on April 24, 2021

Shaik NF, Regan RF, and Naik UP. Platelets as Drivers of Ischemia/Reperfusion Injury after Stroke. Blood Advances. 2021 Mar 9; 5(5): 1576-1584. doi: 10.1182/bloodadvances.2020002888. PMID: 33687431.

Patel P, Shaik NF, Zhou Y, Golla K, McKenzie SE, Naik UP. Apoptosis signal-regulating kinase 1 regulates immune-mediated thrombocytopenia, thrombosis, and systemic shock. J Thromb Haemost. 2020 Nov;18(11):3013-3028. doi: 10.1111/jth.15049. PMID: 32767736.

Chen J, Zhang J, Shaik NF, Yi B, Wei X, Yang XF, Naik UP, Summer R, Yan G, Xu X, Sun J. The histone deacetylase inhibitor tubacin mitigates endothelial dysfunction by up-regulating the expression of endothelial nitric oxide synthase. J Biol Chem. 2019 Dec 20;294(51):19565-19576. doi: 10.1074/jbc.RA119.011317. Epub 2019 Nov 12. PMID: 31719145; PMCID: PMC6926467.

Patel P, Naik MU, Golla K, Shaik NF, Naik UP. Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets. Biochem J. 2019 Oct 15;476(19):2835-2850. doi: 10.1042/BCJ20190410. PMID: 31530712; PMCID: PMC7071732.

Undergrad   Yale University, BS, 2014
Year   MD/PhD 8, JeffMD Phase 2, SKMC 3
Mentor   Richard J. Smeyne, PhD
PhD Program   Neuroscience
Research Interests   Neurodegeneration, Neurodevelopment, Environmental Enrichment, Social Isolation.
Hobbies/Interests   Travel, Foods, Puzzles, Soccer, Billiards, Learning new language  
Favorite Places/Things
to Do in Philadelphia
  Get foods/ice-cream/bubble tea in Chinatown, visit the awesome museums on the Benjamin Franklin Parkway, walk around City Hall, Penn’s Landing and Spruce Street Harbor, run along the Schuylkill River trail, play pool at Buffalo Billiards.
Honors/Awards  

Hobart Amory Hare Honor Society, Pathology Honor Society, 1st rank in Neuroscience Course, Honorable mention in the 9th Annual Annenberg Anatomy Competition.

Undergraduate: Friends of Todai Global Leadership Award, Science, Technology, and Research Scholar (STARS II) research fellowship, Yale College Dean’s Research fellowship, Charles E. Jones Scholarship

 Publications  

A.T. Issa, K. Miyata, V. Heng, K.D. Mitchell, A.V. Derbenev. (2012). Increased neuronal activity in the OVLT of Cyp1a1-Ren2 transgenic rats with inducible Ang II-dependent malignant hypertension. Neuroscience Letters, 519 (1), 26–30.

C. Kubera, A.L. Hernandez, V. Heng, A. Bordey. (2012). Transient mGlu5R inhibition enhances the survival of granule cell precursors in the neonatal cerebellum. Neuroscience, 219 (6), 271–279.

Undergrad   University of Maryland - College Park, BS, 2014
Year   MD/PhD 8, JeffMD Phase 2, SKMC 3
Mentor   Scott Waldman, MD, PhD
PhD Program   Cell Biology & Regenerative Medicine
Research Interests   Cancer genetics, intestinal hormone signaling
Hobbies/Interests   Gardening, woodworking, fostering kittens and pawning them off on co-workers
Favorite Places/Things
to Do in Philadelphia
  Saturday morning farmers’ market in Clark Park
Honors/Awards  

Ruth L. Kirchstein National Research Service Award (NISH, 2018)

Pre-doctoral Fellowship in Pharmacology/Toxicology-PhRMA Foundation (2017)

Dubbs Scholar MD/PhD Fellowship Award-Thomas Jefferson University (2014)

Undergraduate Researcher of the Year Award – University of Maryland (2014)

HHMI Undergraduate Research Fellowship – University of Maryland (2012)

Biomedical Engineering Summer Internship Program (BESIP) Fellowship – NIH (2012)

Solar Decathlon Competition, 1st Place Entry (“WaterShed”) – US Department of Energy (2011)

Banneker-Key Full Academic Scholarship – University of Maryland (2009)

Maryland Distinguished Scholar Academic Scholarship-State of Maryland (2009)

 Publications  

Flickinger JC, Jr., Rappaport JA, Barton JR, Baybutt TR, Pattison AM, Snook AE, Waldman SA. Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies. Biomark Med 2021;15:201-217.

Rappaport JA, Waldman SA. An update on guanylyl cyclase C in the diagnosis, chemoprevention, and treatment of colorectal cancer. Expert Rev Clin Pharmacol 2020:1-13.

Pattison AM, Barton JR, Entezari AA, Zalewski A, Rappaport JA, Snook AE, Waldman SA. Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity. Cancer Biol Ther 2020:1-7.

Blomain ES*, Rappaport JA*, Pattison AM*, Bashir B,* Caparosa E, Stem J, Snook AE, Waldman SA. APC-beta-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. Cancer Biol Ther 2020;21:441-451.

Flickinger JC, Jr., Singh J, Carlson R, Leong E, Baybutt TR, Barton J, Caparosa E, Pattison A, Rappaport JA, Roh J, Zhan T, Bashir B, Waldman SA, Snook AE. Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity. J Immunother Cancer 2020;8.

Merlino DJ, Barton JR, Charsar BA, Byrne MD, Rappaport JA, Smeyne RJ, Lepore AC, Snook AE, Waldman SA. Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin. Brain Struct Funct 2019;224:2983-2999.

Bashir B, Merlino DJ, Rappaport JA, Gnass E, Palazzo JP, Feng Y, Fearon ER, Snook AE, Waldman SA. Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia. Hum Pathol 2019;87:103-114.

Manthe RL*, Rappaport JA*, Long Y, Solomon M, Veluvolu V, Hildreth M, Gugutkov D, Marugan J, Zheng W, Muro S. delta-tocopherol effect on endocytosis and its combination with enzyme replacement therapy for lysosomal disorders: a new type of drug interaction? J Pharmacol Exp Ther 2019.

Rappaport JA, Waldman SA. The guanylate cyclase C-cGMP signaling axis opposes intestinal epithelial injury and neoplasia. Front Oncol 2018;8:299.

Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. GUCY2C signaling opposes the acute radiation-induced GI syndrome. Cancer Res 2017;77:5095-5106.

Kraft CL, Rappaport JA, Snook AE, Pattison AM, Lynch JP, Waldman SA. GUCY2C maintains intestinal LGR5(+) stem cells by opposing ER stress. Oncotarget 2017;8:102923-102933.

Aka AA*, Rappaport JA*, Pattison AM, Sato T, Snook AE, Waldman SA. Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. Expert Rev Clin Pharmacol 2017;10:549-557.

Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA. Intestinal enteroids model guanylate cyclase C-dependent secretion induced by heat-stable enterotoxins. Infect Immun 2016;84:3083-91.

Rappaport J, Papademetriou J, Muro S. Drug Delivery Through the Endo-Lysosomal Route. In: Drug Delivery Across Physiological Barriers, Muro S. (Ed.) Pan Stanford Publishing. 2016

Rappaport J, Manthe RL, Solomon M, Garnacho C, Muro S. A comparative study on the alterations of endocytic pathways in multiple lysosomal storage disorders. Mol Pharm 2016;13:357-368.

Rappaport J, Manthe RL, Garnacho C, Muro S. Altered clathrin-independent endocytosis in type A Niemann-Pick disease cells and rescue by ICAM-1-targeted enzyme delivery. Molecular Pharmaceutics 2015;12:1366-1376.

Rappaport J, Garnacho C, Muro S. Clathrin-mediated endocytosis is impaired in type A-B Niemann-Pick disease model cells and can be restored by ICAM-1-mediated enzyme replacement. Mol Pharm 2014;11:2887-95.

Hsu J, Rappaport J, Muro S. Specific binding, uptake, and transport of ICAM-1-targeted nanocarriers across endothelial and subendothelial cell components of the blood-brain barrier. Pharm Res 2014;31:1855-66

*Denotes equal contribution

Undergrad   University of Pittsburgh, BS, 2013
Year   MD/PhD 7, JeffMD Phase 2, SKMC 3
Mentor   Adam Snook, PhD
PhD Program   Immunology & Microbial Pathogenesis
Research Interests   Immunology, cancer immunology, immunotherapy
Hobbies/Interests   Cooking, fingerstyle guitar, running
Favorite Places/Things
to Do in Philadelphia
  Trying new restaurants, running along the Schuylkill River
Honors/Awards   NIH Postbaccalaureate Intramural Research Training Award
University of Pittsburgh Scholar
Ossip Award for Excellence in Undergraduate Writing
 Publications  

Flickinger, J.C., Jr., Rodeck, U., Snook, A.E. 2018. Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress. Vaccines (6): 48.

Magee, M.S., Abraham, T.S., Baybutt, T.R., Flickinger, J.C., Ridge, N.A., Marszalowicz, G.P., Prajapati, P., Hersperger, A.R., Waldman, S.A. and Snook, A.E. 2018. Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases. Cancer immunology research 6(5):509-516.

Kwong, B., Rua, R., Gao, Y., Flickinger, J., Wang, Y., Kruhlak, M.J., Zhu, J., Vivier, E., McGavern, D.B. and Lazarevic, V. 2017. T-bet-dependent NKp46(+) innate lymphoid cells regulate the onset of TH17-induced neuroinflammation. Nature Immunology 18(10), pp. 1117–1127.

Leeman JE, Flickinger JC Jr, Clump DA, Wegner RE, Heron DE, Burton SA, Mintz AH. Detection and Treatment of Small Brain Metastases Resulting from Renal Cell Carcinoma Predict Improved Survival After Stereotactic Radiosurgery.  2012. Journal of Radiation Oncology 7:107.

Flickinger JC Jr, Kim H, Kano H, Greenberger JS, Arai Y, Niranjan A Lunsford LD, Kondziola D, Flickinger JC Sr. 2012. Do Carbamazepine, Gabapentin, or Other Anticonvulsants Exert Sufficient Radioprotective Effects to Alter Responses from Trigeminal Neuralgia Radiosurgery? Int J Radiat Oncol Biol Phys. 15; 83(4): e501-6

Kim H, Bernard ME, Flickinger J, Epperly MW, Wang H, Dixon TM, Shields D, Houghton F, Zhang X, Greenberger JS. 2011. The Autophagy Inducing Drug Carbamazepine is a Radiation Protector and Mitigator. Int J Radiat Biol (10): 1052-60.

Undergrad University of Massachusetts Amherst, Biochemistry and Molecular Biology, 2014
Year MD/PhD 7, JCLS 5
Mentor Christine Eischen, PhD
PhD Program Immunology & Microbial Pathogenesis
Research Interests I am focusing on understanding the contributions of the DNA replication stress response to hematopoiesis and the effects of different replication stressors on developing hematopoietic cells.
Anticipated Residency Internal Medicine followed by a fellowship in Hematology & Oncology
Hobbies/Interests Hosting/attending potlucks, board games, reading/watching science fiction/fantasy and anime, spending time with the Jewish community
Favorite Places/Things
to Do in Philadelphia
Spruce Street Harbor, Schuylkill river trail and dog park
Honors/Awards

Ruth L. Kirschstein National Research Service Award, F30 Fellowship (2020)

Thomas Jefferson University Dean’s Student Collaborator Award (2016)

Northeast Undergraduate Research and Development Symposium Best Poster Presentation (2014)

Commonwealth Honors College Research Grant, University of Massachusetts Amherst (2013)

C.D. Youngren Research Scholarship, University of Massachusetts Amherst (2013)

Scientific Research Assistant Fellowship, University of Massachusetts Amherst (2011)

Eagle Scout Award, Boy Scouts of America (2009)

Publications Puccetti, M.V., Adams C.M., Kushinsky S., and Eischen C.M. Smarcal1 and Zranb3 Protect Replication Forks from Myc-Induced DNA Replication Stress. Cancer Research, 79:1612-23, 2019.(PMC6445766)

Undergrad   University of Delaware, BS, 2016
Year   MD/PhD 6, JCLS 4
Mentor   Scott Waldman, MD, PhD
PhD Program   Neuroscience
Research Interests  

I’d really like to develop a therapy in the lab for patients that I work with in the clinic. For neurology, in particular, there are a lot of people suffering from diseases with no prospects for improvement, and I’d love to give them some hope. I think our understanding of the brain is going to grow and change drastically during our lifetime and I’d like to be part of figuring that out.

Hobbies/Interests   Cooking, Golf, Disc Golf, Animals, Any kind of game, and any kind of music
Favorite Places/Things
to Do in Philadelphia
  Music Bingo at Manny Brown’s on South St, Chilling with animals at the Zoo, Every booth at Reading Terminal Market
Honors/Awards   Biological Sciences Undergraduate Research Award (University of Delaware), Delaware Governor’s Bioscience Fellowship Award (University of Delaware), PhRMA Predoctoral Fellowship (TJU), NIH F30 Fellowship F30DK127639 (TJU)
 Publications  

Barton, J. R., Snook, A. E., & Waldman, S. A. (2021). From leptin to lasers: the past and present of mouse models of obesity. Expert Opinion on Drug Discovery, 1-14.

Flickinger Jr, J. C., Rappaport, J. A., Barton, J. R., Baybutt, T. R., Pattison, A. M., Snook, A. E., & Waldman, S. A. (2021). Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies. Biomarkers in Medicine, 15(3), 201-217. 

Flickinger Jr, J. C., Singh, J., Carlson, R., Leong, E., Baybutt, T. R., Barton, J., ... & Zhan, T. (2020). Chimeric Ad5. F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity. Journal for immunotherapy of cancer8(2).

Pattison AM, Barton JR, Entezari AA, et al. Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity. Cancer Biology & Therapy 2020:1-7.

Merlino DJ*, Barton JR*, Charsar BA, et al. Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin. Brain Structure and Function 2019;224:2983-2999.

Weatherbee, B. A.*, Barton, J. R.*, Siddam, A. D.*, Anand, D., & Lachke, S. A. (2019). Molecular characterization of the human lens epithelium-derived cell line SRA01/04. Experimental eye research, 188, 107787.

Undergrad   Oberlin College, BA, 2015
Year   MD/PhD 6, JCLS 4
Mentor   Hushan Yang, PhD
PhD Program   Cell Biology & Regenerative Medicine
Research Interests   My current research interest pertains to non-invasive liquid biopsies such as circulating tumor DNA and circulating tumor cells, especially using next-generation sequencing to identify biomarkers that may aid prognosis and therapeutic selection.
Hobbies/Interests   I like cooking, cycling and playing the guitar to my young daughter.
Favorite Places/Things
to Do in Philadelphia
  I love watching the pups at the doggie park along the Schuylkill River Trail (it’s pronounced SKOOL-kul).
Honors/Awards   Elected into Phi Beta Kappa. May 2015
Awarded 1st place in the Sigma Xi Student Presentation Showcase 2015 (Undergraduate Division). Mar 2015
Elected into Sigma Xi, the Scientific Research Society. Mar 2015
Awarded the Robert Rich Grant from Oberlin College Robert Rich Foundation for outstanding research in the natural sciences. Mar 2015
Awarded the Pfizer-SOT Award to attend the Annual Society of Toxicology Meeting held in San Diego, CA (Mar 21 – Mar 26, 2015). Dec 2014  
 Publications  

Wang C, Zhang Z, Chong W, Luo R, Myers RE, Gu J, Lin J, Wei Q, Li B, Rebbeck TR, Lu-Yao G. Improved Prognostic Stratification Using Circulating Tumor Cell Clusters in Patients with Metastatic Castration-Resistant Prostate Cancer. Cancers. 2021 Jan;13(2):268.

Y Hai*, Chong W*, J Liu, F Forsberg, J Eisenbury. The Diagnostic Value of Contrast- Enhanced Ultrasound for Monitoring Complications After Kidney Transplantation—A Systematic Review and Meta-Analysis. Academic Radiology. 2020 https://doi.org/10.1016/j.acra.2020.05.009

Zhang Y, Tan H, Tang J, Li J, Chong W, Hai Y, Feng Y, Lunsford LD, Xu P, Jia D, Fang F. Effects of vitamin D supplementation on prevention of type 2 diabetes in patients with prediabetes: a systematic review and meta-analysis. Diabetes Care. 2020 Jul 1;43(7):1650-8.

Book: Le, Tao; Bhushan, Vikas; Sochat, Matthew; Chavda, Yash; Zureick, Andrew; Kalani, Mehboob; and Kallianos, Kimberly, Chong, Weelic; et al. First Aid for the USMLE Step 1 2020. New York: McGraw-Hill Education, 2019. Chong, W., Jiménez, J., McIIvin, M., Saito, M. A., & Kwakye, G. F. (2017). α-Synuclein Enhances Cadmium Uptake and Neurotoxicity via Oxidative Stress and Caspase Activated Cell Death Mechanisms in a Dopaminergic Cell Model of Parkinson’s Disease. Neurotoxicity research, 32(2), 231-246.

Other articles on researchgate:

https://www.researchgate.net/profile/Weelic-Chong

Undergrad   University of Pennsylvania, BA, 2016
Year   MD/PhD 6, JCLS 4
Mentor   Noreen Hickok, PhD
PhD Program   Cell Biology & Regenerative Medicine
Research Interests   N/A
Hobbies/Interests   N/A
Favorite Places/Things
to Do in Philadelphia
  N/A
Honors/Awards   N/A
 Publications  

Knott, S.; Curry, D.; Zhao, N.; Metgud, P.; Dastgheyb, S.; Purtill, C.; Harwood, M.; Chen, A. F.; Schaer, T. P.; Otto, M.; et al. Staphylococcus aureus floating biofilm formation and phenotype in synovial fluid depends on albumin, fibrinogen, and hyaluronic acid. Frontiers in Microbiology 2021.

Shapiro, I. M. & Zhao, N. (2021) Stemming Osteogenic Defects: Stem Cell Repair of Skeletal Lesions. In A. E. Ghannam (Ed.), Bioceramics and their Clinical Applications 2e. Amsterdam, Netherlands: Elsevier.

Forsberg, F., Curry, D., Machado, P., Zhao, N., Stanczak, M., Eisenbrey, J.R., Schaer, T.P., Hickok, N.J. Ultrasound triggered microbubble destruction for disrupting biofilms in synovial fluid. Online poster session presented at IEEE International Ultrasonics Symposium; 2020; Virtual Symposium.

Zhao, N., Curry, D., Metgud, P., Hickok N. Treating Staphylococcus aureus in synovial fluid: a new application of the plant-derived alkaloid berberine. Poster session presented at: Orthopaedic Research Society Meeting; 2020; Phoenix, Arizona.

Zhao, N., Curry, D., Hickok, N. Restoring antibiotic susceptibility of Staphylococcus aureus aggregates in synovial fluid. Poster session presented at: American Physician Scientists Meeting; 2019; Chicago, Illinois.

Nguyen, L., Zhao, N., Fitzgerald, K., Toorkey, C., Hickok, N., Freeman, T. Cold Plasma Eradication of Escherichia coli and Staphylococcus aureus Biofilms. Poster session presented at: American Society of Cellular Biology Meeting; 2017; Philadelphia, PA.

Undergrad   Ursinus College, BS, 2017
Year   MD/PhD 5, JCLS 3
Mentor   Andrew Aplin, PhD
PhD Program   Cell Biology & Regenerative Medicine
Research Interests   I am interested in translational cancer biology research. I like to understand molecular mechanisms of cancer that will help modulate future cancer therapies.
Hobbies/Interests   Outside of science I like to read science-fiction/fantasy books and play pick-up sports (give me any ball and I’ll chase after it). I also enjoy adventure trips with family and friends (hiking, camping, skiing, etc.).
Favorite Places/Things
to Do in Philadelphia
  I am a big fan of escape rooms and there are tons of new places in Philadelphia I have yet to explore. My favorite aspect of Philadelphia is being able to go to any corner of the street and finding a halal cart.
Honors/Awards  

Outstanding Research Student in Biology Award, Ursinus College, 2017

Medical Student Award from the Melanoma Research Foundation, February 2020

 Publications  

Loomis, C., Stephens, A., Janicot, R., Baqai, U., Drebushenko, L., & Round, J. (2020). Identification of MAGUK scaffold proteins as intracellular binding partners of synaptic adhesion protein Slitrk2. Molecular and Cellular Neuroscience, 103, 103465.

Teh, J. L., Purwin, T. J., Han, A., Chua, V., Patel, P., Baqai, U., ... & Aguirre-Ghiso, J. A. (2020). Metabolic adaptations to MEK and CDK4/6 co-targeting in uveal melanoma. Molecular Cancer Therapeutics.

Undergrad   Rutgers University, BA, 2014
Year   MD/PhD 5, JCLS 3
Mentor   Scott Waldman, MD, PhD
PhD Program   Neuroscience
Research Interests   I’m interested in studying neurodegenerative diseases, and have spent just under four years researching the potential of ketamine to treat depression and the possibility of endogenous factors in the brain to treat multiple sclerosis. Learning new techniques is exciting and rewarding, but I really appreciate being trained on how to approach new scientific problems.
Hobbies/Interests   As soon as I save enough money, I spend it on traveling somewhere new, and tend to contract food poisoning at least once every trip. I enjoy hiking, reading, and spending a good amount of time drinking coffee with my family and alcohol with my friends.
Favorite Places/Things
to Do in Philadelphia
  One of my routine activities in Philly is Muay Thai, which I practice a few times a week in Philly. No official fighting yet, though. I also love browsing the Italian market for the deal of the day (like a bucket of tangerines for $1), and when money is decent, I splurge on the best cappuccinos in the city at Function Coffee Labs.
Honors/Awards   Graduated magna cum laude from Rutgers
 Publications  

Alvarez JI, Kebir H, Cheslow L, Larochelle C, Charabati M, Prat A. JAML mediates monocytes and CD8 T cell migrations across the brain endothelium. Ann Clin Transl Neurol. 2015 Sep 29;2(11):1032-7.

Cheslow L, Alvarez JI. Glial-endothelial crosstalk regulates blood–brain barrier function. Current Opinion in Pharmacology. 2016 Feb;26:39-46.

Undergrad   Wellesley College, BA, 2013
Year   MD/PhD 5, JCLS 3
Mentor   Anjali Mishra, PhD
PhD Program   Cell Biology & Regenerative Medicine
Research Interests   I am conducting my graduate research in the lab of Dr. Anjali Mishra in the Department of Medical Oncology. My current work is investigating novel targets for therapeutic intervention in Cutaneous T-Cell Lymphoma. My research interests span the fields of dermatology, hematology, and immunology. 
Hobbies/Interests   At Jefferson, I was on the elected board of the Jefferson Physician Scientist Association for three years and am active in volunteering with the intensive care nursery cuddling program in the hospital. In my spare time, I enjoy exploring restaurants in Philly (especially Dim Sum) and spending time outdoors.
Favorite Places/Things
to Do in Philadelphia
  Spruce St. Harbor Park is a great place to go during the summer for music, food, and fun. The Schuylkill River Trail is also a lovely place to walk and ride bikes. 
Honors/Awards   Hobart Amory Hare Medical Honor Society, Phi Beta Kappa, Wellesley College Durant Scholar, The Klein Prize in Neuroscience 2013 at Wellesley College
 Publications  

Gamlen, H.A., Romer-Seibert, J., Lawler, M., Versace, A.M., Isabelle, C., Mishra, A., Meyer, S.E. (2021). miR-196b-TLR7/8 signaling axis regulates innate immune signaling and myeloid maturation in DNMT3A-mutant AML. Blood. (Under Review).

Lee, H., Fei, Q., Streicher, A., Zhang, W., Isabelle, C., Patel, P., Lam, H., Arciniegas, A., Pinilla-Vera, M., Amador-Munoz, D., Barragan-Bradford, D., Higuera, A., Putman, R., Sholl, L., Henske, E., Bobba, C., Higuita-Castro, N., Shalosky, E., Hite, R.D., Christman, J., Ghadiali, S., Baron, R.M., Englert, J. A. (2021). mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury. JCI insight (Under Review).

Englert JA, Cho MH, Lamb AE,  Shumyatcher M, Barragan-Bradford D, Basil MC, Higuera A, Isabelle C, ... Baron, RM. Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation. Respir Res. 2019;20(1):15. Published 2019 Jan 21. doi:10.1186/s12931-019-0981-6

Boudreault, F., Pinilla-Vera, M., Englert, J. A., Kho, A. T., Isabelle, C., Arciniegas, A. J., . . . Baron, R. M. (2017). Zinc deficiency primes the lung for ventilator-induced injury. JCI Insight, 2(11). doi:10.1172/jci.insight.86507

Englert, J. A., Macias, A. A., Amador-Munoz, D., Vera, M. P., Isabelle, C., Guan, J. Baron, R. M. (2015). Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity. Anesthesiology, 123(2), 377-388. doi:10.1097/aln.0000000000000742

Undergrad   Yale College, BS, 2015
Year   MD/PhD 5, JCLS 3
Mentor   Noreen Hickok, PhD / Flemming Forsberg, PhD
PhD Program   Cell Biology & Regenerative Medicine
Research Interests  

Past experience: Computational analysis, glucose metabolism, endocrinology;  Clinical research, acute kidney injury, acute interstitial nephritis, nephrology

Thesis research: Infection control, antibiotic prophylaxis, biomaterials, therapeutic ultrasound

Hobbies/Interests   Art and art history, traveling, photography.
Favorite Places/Things
to Do in Philadelphia
  I love trying new food (or revisiting old favorites) and going to art galleries or other cultural places. One of my favorites has been the Philadelphia Chinese Lantern Festival so far, which I believe is the largest one in the country!
Honors/Awards   Phase-1 Dean’s Student Research Prize (2019)
 Publications  

Isguven, S., Chung, P. H., Machado, P., Delaney, L. J., Chen, A. F., Forsberg, F., & Hickok, N. J. (2020). Minimizing penile prosthesis implant infection: what can we learn from orthopaedic surgery?. Urology.

L. J. Delaney, M. Aliabouzar, S. Isguven, J. R. Eisenbrey, M. Fabiilli, N. J. Hickok, F. Forsberg.  Ultrasound-sensitive hydrogel for drug delivery applications.  J Ultrasound Med, vol. 39(Suppl), pp. S14, 2020.

Moledina, D. G., Isguven, S., McArthur, E., Thiessen-Philbrook, H., Garg, A. X., Shlipak, M., ... & Parikh, C. R. (2017). Plasma monocyte chemotactic protein-1 is associated with acute kidney injury and death after cardiac operations. The Annals of thoracic surgery, 104(2), 613-620.

Isguven, S. (2016). An Ethical Argument for Regulated Cognitive Enhancement in Adults: The Case of Transcranial Direct Current Stimulation (tDCS). Voices in Bioethics, 2.

Undergrad   University of California, Berkeley, BA, 2015
Year   MD/PhD 5, JCLS 3
Mentor   Matthew Dalva, PhD
PhD Program   Neuroscience
Research Interests  

I’m primarily interested in neuroscience. I enjoy learning about the dynamics of synapses and neural circuits in different neurological states. Specifically, I want to study more about the neural circuit level basis for behavioral dysfunction exhibited in neurodevelopmental or neurodegenerative diseases such as Autism Spectrum Disorder or Alzheimer’s Disease.

Hobbies/Interests   I like to spend my time mostly outdoors which usually includes hiking, camping, or whatever activity I can do in nature. Sometimes when the Philly weather isn’t as nice to me, I’ll read a book, watch a movie, or play Settlers of Catan.
Favorite Places/Things
to Do in Philadelphia
  My opinion is that Philly is best known for its parks and its food. Favorite park: Wissahickon Valley. Favorite food: cheesesteaks from Ishkabibble’s.
Honors/Awards   I.L. Chaikoff Memorial Award (Berkeley)
 Publications   Hruska M, Henderson N, Le Marchand SJ, Jafri H, Dalva MB. (2018). Synaptic nanomodules underlie the organization and plasticity of spine synapses. Nat Neurosci. 21(5):671-682.

Elstrott J, Clancy KB, Jafri H, Akimenko I, Feldman DE. (2014). Cellular mechanisms for response heterogeneity among L2/3 pyramidal cells in whisker somatosensory cortex. J Neurophysiol. 112(2):233-48.

Undergrad Swarthmore College, BA, 2017
Year MD/PhD 4, JCLS 2
Mentor Manuel Covarrubias, MD, PhD
PhD Program Neuroscience
Research Interests

I am highly interested in neuroscience, biophysics, and mathematics. In particular, I enjoy exploring computational and electrophysiologic questions with translational applications. I am particularly excited by the interdisciplinary aspects of the field and its intersection with physics, mathematics, and philosophy.

Anticipated Residency Neurosurgery
Hobbies/Interests I enjoy distance running and playing blues and jazz guitar. I am an avid reader and love to look at the stars with my telescope.
Favorite Places/Things
to Do in Philadelphia
Run along the Schuylkill River trail, read a book in Rittenhouse square.
Honors/Awards

PhD Award for Excellence in Interprofessional Education and Collaborative Practice (TJU, 2020)

Excellence in Social Impact Award (University of Pennsylvania, 2018)
Honors in NPLD Practicum (University of Pennsylvania, 2018)
Philadelphia Social Innovation Award (Finalist, 2017)
Anti-Poverty Solutions Summit (Winner, 2016)
Foundation Grant Recipient (Swarthmore College, 2014)
Lang Opportunity Scholarship (Swarthmore College, 2013-2017)

Publications

Bowles DR, Canseco JA, Alexander TD, Schroeder GD, Hecht AC, Vaccaro AR. The Prevalence and Management of Stingers in College and Professional Collision Athletes. Curr Rev Musculoskelet Med. 2020. doi:10.1007/s12178-020-09665-5

Sweid A, Hammoud B, Ramesh S, et al. Acute ischaemic stroke interventions: large vessel occlusion and beyond. Stroke Vasc Neurol. 2020;5(1):80 LP - 85. doi:10.1136/svn-2019-000262

Sweid A, Weinberg JH, Abbas R, et al. Predictors of ventriculostomy infection in a large single-center cohort. J neurosurgery. 2020;1(aop):1-8. doi:10.3171/2020.2.JNS192051

Sweid A, Weinberg JH, Xu V, et al. Mechanical Thrombectomy in Acute Ischemic Stroke Patients Greater than 90 Years of Age: Experience in 26 Patients in a Large Tertiary Care Center and Outcome Comparison with Younger Patients. World Neurosurg. 2020;133:e835-e841. doi:https://doi.org/10.1016/j.wneu.2019.10.024

Sweid A, Head J, Tjoumakaris S, et al. Mechanical Thrombectomy in Distal Vessels: Revascularization Rates, Complications, and Functional Outcome. World Neurosurg. 2019;130. doi:10.1016/j.wneu.2019.07.098

Alexander TD, McGovern SK, Leary M, Abella BS, Blewer AL. Association of state-level CPR training initiatives with layperson CPR knowledge in the United States. Resuscitation. 2019;140. doi:10.1016/j.resuscitation.2019.04.037

Sweid A, Rahm SP, Das S, et al. Safety and Efficacy of Bilateral Flow Diversion for Treatment of Anterior Circulation Cerebral Aneurysms. World Neurosurg. 2019;130. doi:10.1016/j.wneu.2019.07.115

Sweid A, Starke RM, Herial N, et al. Predictors of Complications, Functional Outcome, and Morbidity in a Large Cohort Treated With Flow Diversion. Neurosurgery. December 2019. doi:10.1093/neuros/nyz508

Blewer, Audrey L, Alexander, Tyler D, Riegel, Barbara, Asch, David, Bosworth, Hayden, Viera, Anthony, Abella B. Increasing pragmatic clinical trial enrollment using social and financial incentives. Circulation. 2019.

Das S, Ramesh S, Baldassari M, et al. Evaluating Perceptions of Deep Brain Stimulation in DBS-naïve Patients with Parkinson’s Disease–A Pilot Study: 2017. Mov Disord. 2019;34.

Arbuckle, D. S., Howard, K. P., Alexander, T., & Crouch, C. (2017). Site-Directed Spin-Label EPR Spectroscopy of M2 Protein in Lipid Bilayers of Different Curvature Generation Propensity. Biophysical Journal, 112(3), 505a. doi:10.1016/j.bpj.2016.11.2733

Undergrad Penn State Premedical/Medical Accelerated Program, 2018
Year MD/PhD 4, JCLS 2
Mentor Matthew Dalva, PhD
PhD Program Neuroscience
Research Interests Neuroscience, neurosurgery, synaptic biology
Anticipated Residency Ophthalmology
Hobbies/Interests N/A
Favorite Places/Things
to Do in Philadelphia
N/A
Honors/Awards

SKMC

SKMC Dean’s Student Research Award (2020)

Hobart Amory Hare Society Member (2020-present)

Pennsylvania State University

Euroscholar Scholarship Award (2018)

Evan Pugh Senior Scholar Award (2017)

Dean’s List (2015, 2016, 2017)

Mark and Sharon Robb Research Award (2017)

Pre-Medicine Scholarship (2016, 2017)

Ruth E.Duffy Pre-Medicine Endowment (2016, 2017)

Publications

Zheng, W., Parry, M., Hou, X., Liu, M., Wang, H., Cain, R., Pei, Z., Chen, Y., Guo, Z., Abhijeetm S., Chen, G. “Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease.” Nat Commun 11, 1105 (2020). https://doi.org/10.1038/s41467-020-14855-3

Hruska, M., Cain, R., Dalva, M. “Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific.” (In review)

Datta T, Lee AJ, Cain R, McCarey M, Whellan DJ. Weighing in on heart failure: the potential impact of bariatric surgery. Heart Fail Rev. 2021 Jan 25. doi: 10.1007/s10741-021-10078-w.

Pendleton, C., Velagapudi, L., Cain, R., Jallo, J. Fixed Positioning for Decompressive Hemicraniectomy Provides a Larger Diameter Flap than Nonfixed Positioning: A Single-Institution Experience. World Neurosurgery. 2020 July. https://doi.org/10.1016/j.wneu.2020.03.205.

Undergrad Brown University, BSc, 2016
Year MD/PhD 4, JCLS 2
Mentor Andrew Aplin, PhD
PhD Program Cell Biology & Regenerative Medicine
Research Interests I am interested in translational research in cancer biology, with an emphasis on cell signaling and cancer genetics
Anticipated Residency TBD
Hobbies/Interests Reading, writing, and taking photographs. I also enjoy hiking, running, being outdoors, and traveling. I am also an avid polo player, having started playing as an undergraduate student.
Favorite Places/Things
to Do in Philadelphia
Checking out the Rodin Museum and Barnes Foundation, grabbing coffee in Rittenhouse and going for a walk around Graduate Hospital, hiking in Wissahickon Valley Park, eating pizza in Fishtown.
Honors/Awards

Medical Student Award (Melanoma Research Foundation, 2021)

Hobart Amory Hare Medical Honor Society (Thomas Jefferson University, 2020)       

James B. Erdmann Student Award for Excellence in Interprofessional Education and

Collaborative Practice (Thomas Jefferson University, 2020)                                   

Inducted to Sigma Xi: The Scientific Honor Society (Brown University, 2016)         

Karen T. Romer Undergraduate Teaching and Research Award (Brown University, 2015)

BrownConnect LINK Award (Brown University, 2014)

Publications

Joseph T.V., Caksa S., Misra M., Mitchell D.M. Hip structural analysis reveals impaired hip geometry in girls with type 1 diabetes. Journal of Clinical Endocrinology & Metabolism. 2020 Dec; 105(12): 1-9

Mitchell D.M., Caksa S., Joseph T.V., Bouxsein M.L., Misra M. Elevated HbA1c is associated with altered cortical and trabecular microarchitecture in girls with type 1 diabetes. Journal of Clinical Endocrinology & Metabolism. 2020 Apr; 105(4): 1-9.

Caksa S., Yuan A., Rudolph S. E., Yu E. W., Popp, K.L., Bouxsein M. L. Influence of soft tissue on bone density and microarchitecture measurements by high-resolution peripheral quantitative computed tomography. Bone. 2019 Jul; 124: 47-52.

Popp K.L., Caksa S., Martinez-Betancourt A., Yuan A., Tsai J.N., Yu E.W., Bouxsein M.L. Cortical bone material strength index and bone microarchitecture in postmenopausal women with atypical femoral fractures. Journal of Bone and Mineral Research. 2019 Jan; 34 (1): 75-82.

Unnikrishnan, G., Xu, C., Popp, K.L., Hughes J.M., Caksa, S., Guerriere K.I., Ackerman, K.E., Bouxsein, M.L., Reifman, J. Regional variation of bone density, microarchitectural parameters, and elastic moduli in the ultradistal tibia of young black and white men and women. Bone. 2018 Jul; 112: 194-201.

Rozental, T.D., Walley, K.C., Demissie, S., Caksa, S., Martinez-Betancourt, A., Parker, A. M. Tsai, J. N., Yu, E. W., Bouxsein, M. L. Bone material strength index as measured by impact microindentation in postmenopausal women with distal radius and hip fractures. Journal of Bone and Mineral Research. 2018 Apr; 33(4): 621-626.

Mitchell, D.M., Caksa S., Yuan A., Bouxsein M.L., Burnett-Bowie, S.M., Misra M. Trabecular bone morphology correlates with skeletal maturity and body composition in healthy adolescent girls. Journal of Clinical Endocrinology & Metabolism. 2018 Jan; 103(1): 336-345.

Popp K.L., Hughes J.M., Martinez-Betancourt A., Scott M., Turkington V., Caksa S., Guerriere K.I., Ackerman K.E., Xu C., Unnikrishnan G., Reifman J., Bouxsein M.L. Bone mass, microarchitecture and strength are influenced by race/ethnicity in young adult men and women. Bone. 2017 Oct; 103: 200-208.

Undergrad Cornell University, BA, 2017
Year MD/PhD 3, JCLS 1
Mentor TBD
PhD Program TBD
Research Interests I'm currently interested in the field of neuroscience, specifically the molecular pathogenesis of neurodegenerative diseases.
Anticipated Residency TBD
Hobbies/Interests Baking/cooking, reading, watching soccer and cricket, learning new languages.
Favorite Places/Things
to Do in Philadelphia
I have a lot more exploring to do, but so far I'm enjoying exploring the varied food options, and the arts and music scene here!
Honors/Awards

Tata Scholarship (Cornell University, 2013-2017)

Von Stade Fellowship (CSHL, 2016)

Burroughs Wellcome Fellowship (CSHL, 2016)

Publications

Martuscello RT, Kerridge CA, Chatterjee D, Hartstone WG, Kuo SH, Sims PA, Louis ED, Faust PL. Gene Expression Analysis of the Cerebellar Cortex in Essential Tremor. Neurosci Lett. 2020 Mar 16;721:134540.

Louis ED, Kerridge CA, Chatterjee D, Martuscello RT, Diaz DT, Koeppen AH, Kuo SH, Vonsattel JG, Sims PA, Faust PL. Contextualizing the Pathology in the Essential Tremor Cerebellar Cortex: A Patholog-omics Approach. Acta Neuropathol. 2019 Nov;138(5):859-876.

Lee PJ, Kerridge CA, Chatterjee D, Koeppen AH, Faust PL, Louis ED. A Quantitative Study of Empty Baskets in Essential Tremor and Other Motor Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2019 Feb 1;78(2):113-122.

Setiono FJ, Chatterjee D, Fuchs M, Perry KL, Thompson JR. The Distribution and Detection of Grapevine red blotch virus in its Host Depend on Time of Sampling and Tissue Type. Plant Dis. 2018 Nov;102(11):2187-2193.

Lee PJ, Kerridge CA, Chatterjee D, Koeppen AH, Faust PL, Louis ED. A Quantitative Study of Empty Baskets in Essential Tremor and Other Motor Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2019 Feb 1;78(2):113-122.

Setiono FJ, Chatterjee D, Fuchs M, Perry KL, Thompson JR. The Distribution and Detection of Grapevine red blotch virus in its Host Depend on Time of Sampling and Tissue Type. Plant Dis. 2018 Nov;102(11):2187-2193.

Louis ED, Kerridge CA, Chatterjee D, Martuscello RT, Trujillo-Diaz D, Koeppen AH, Kuo SH, Vonsattel JG, Faust PL. Contextualizing the Changes in the Essential Tremor Cerebellum: A Comparative Postmortem Study (under review, Acta Neuropathol).

Martuscello RT, Kerridge CA, Chatterjee D, Hartstone WG, Kuo SH, Sims PA, Louis ED, Faust PL. Gene Expression Analysis of the Cerebellar Cortex in Essential Tremor (under review, Neurosci Lett)

Undergrad UC Davis, BS, 2018
Year MD/PhD 3, JCLS 1
Mentor Angelo Lepore, PhD
PhD Program Neuroscience
Research Interests I have a love for molecular neuroscience, especially receptor biology. Working with Dr. Tian in undergraduate, I learned how to create receptor-based, protein sensors for imaging. I hope to apply this knowledge in a more clinical fashion as my career continues.
Anticipated Residency N/A
Hobbies/Interests It's a cliche, I know, but I really love eating. I usually cook, but there's only so much I can make. Thankfully, Philadelphia delivers a plethora of cuisine. I also love simply walking around the city and rock climbing at our local gym.
Favorite Places/Things
to Do in Philadelphia
Washington square is one of my favorite parks to just sit down and relax. South St. is always bustling with life and has some truly fantastic restaurants. Lastly it would be unfair to not recommend reading market to find great food and cooking ingredients.
Honors/Awards N/A
Publications

Undergraduate:

Singer GA, Loya FP, Lapsley WD, et al. Detection of Bartonella infection in pet dogs from Manila, the Philippines. Acta Trop. 2020;205:105277.

Weinborn-Astudillo RM, Pau N, Tobar BZ, et al. Bartonella Infection in Stray Dogs from Central and Southern Chile (Linares and Puerto Montt). Vector Borne Zoonotic Dis. 2020;20(3):187-192.

Raya AP, Jaffe DA, Chomel BB, et al. Detection of Bartonella species, including Candidatus Bartonella ovis sp. nov, in ruminants from Mexico and lack of evidence of Bartonella DNA in saliva of common vampire bats (Desmodus rotundus) predating on them. Vet Microbiol. 2018;222:69-74.

Moskaluk AE, Stuckey MJ, Jaffe DA, et al. Molecular Detection of Bartonella Species in Blood-Feeding Bat Flies from Mexico. Vector Borne Zoonotic Dis. 2018;18(5):258-265.

Jaffe DA, Chomel BB, Kasten RW, et al. Bartonella henselae in small Indian mongooses (Herpestes auropunctatus) from Grenada, West Indies. Vet Microbiol. 2018;216:119-122.

Undergrad Colby College, ME, Class of 2017
Year MD/PhD 3, JCLS 1
Mentor Sue Menko, PhD
PhD Program Cell Biology & Regenerative Medicine
Research Interests Cancer immunobiology and tumor microenvironment
Anticipated Residency Maybe Pediatric Hem/Onc or Pathology 
Hobbies/Interests Biking, hiking, handicrafts, baking
Favorite Places/Things
to Do in Philadelphia
Riding along Schuylkill river is my jam!
Honors/Awards

Phi Beta Kappa

American Society for Biochemistry and Molecular Biology Travel Award (2017)

Biddle Fund Award for International Research (2015) 

Charles A. Dana Scholar (2014)  

Cancer Prevention & Research Institute of Texas Summer Scholar (2013, 2014)

Publications

Sarkizova, S., Klaeger, S., Le, P.M., Li, L.W., Oliveira, G.,..., Keskin, D.B. (2020). A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Nat Biotechnol. 38, 199-209. 

Keskin, D.B., Anandappa, A.J., Sun, J., Tirosh, I., …Le, P.M., …Reardon, D.A. (2019). Personal neoantigen-targeting vaccination for glioblastoma (GBM) generates intra-tumoral T cell response. Nature 565, 234–239.

Le, P.M., Andreeff, M., Battula, V.L. (2018). Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis. Haematologica. doi:10.3324/haematol.2018.197004.

Le, P.M., Silvestri, V.L., Redstone, S.C., Dunn, J.B., & Millard, J.T. (2018). Cross-linking by epichlorohydrin and diepoxybutane correlates with cytotoxicity and leads to apoptosis in human leukemia (HL-60) cells. Toxicology and Applied Pharmacology 352, 19-27.

Battula, V.L., Le, P.M., Sun, J.C., Nguyen, K., Yuan, B., Zhou, X., … Andreeff, M. (2017). AML-induced osteogenic differentiation in mesenchymal stromal cells supports leukemia growth. JCI Insight, 2 (13).

Undergrad Rutgers University New Brunswick, BA, 2013
Year MD/PhD 3, JCLS 1
Mentor Angelo Lepore, PhD
PhD Program Neuroscience
Research Interests I am interested in neuroscience, specifically in the context of traumatic CNS injuries and the mechanisms that underlie neuronal regeneration and repair. I would like to advance our understanding of these processes in order to develop better therapeutic strategies to 1) limit and protect against damage caused by secondary injury cascades and 2) ultimately improve functional recovery for patients.
Anticipated Residency N/A
Hobbies/Interests I enjoy spending time outdoors, including hiking and camping.
Favorite Places/Things
to Do in Philadelphia
I like to explore new places to eat, Philadelphia has many wonderful restaurants. The Italian Market is also great.
Honors/Awards Undergraduate:
Division of Life Sciences Summer Undergraduate Research Fellowship (2010)
Division of Life Sciences Summer Undergraduate Research Fellowship (2011)
Publications  

Undergrad Columbia University, BA, 2016
Year MD/PhD 3, JCLS 1
Mentor TBD
PhD Program TBD
Research Interests Previously, I researched the genetic causes of Autism Spectrum Disorder, pachygyria and meningiomas for two years using whole exome sequencing, gene editing, molecular and biochemical analytical techniques and data prioritization methods to arrive at genetic discoveries. Though I would like to keep working on translational research topics, I would like to branch out from neurological disease models and use my MD/Ph.D. training to learn about other areas.
Anticipated Residency Ophthalmology and luckily, Jefferson offers one of the nation’s top programs
Hobbies/Interests Listening to live music especially R&B and alternative rock, dancing, reading, traveling, following world politics and some sports I enjoy are swimming, tennis, skiing and running.
Favorite Places/Things
to Do in Philadelphia
As someone who recently arrived in Philly, I have limited knowledge of the city but so far, I have enjoyed spending time in Old City where one can visit the historic landmarks, take a stroll through the beautiful parks and admire Philly’s classic row houses. Penn’s Landing and Fishtown are two other popular places which I have yet to explore!
Honors/Awards  
Publications

Mishra-Gorur, K., Li, D., Ma, X., Yarman, Y., Xue, L. and Xu, T., 2019. Spz/Toll-6 signal guides organotropic metastasis in Drosophila. Disease models & mechanisms12(10), p.dmm039727

Kaymakcalan, H., Yarman, Y., Goc, N., Toy, F., Meral, C., Ercan‐Sencicek, A.G. and Gunel, M., 2018. Novel compound heterozygous mutations in GPT2 linked to microcephaly, and intellectual developmental disability with or without spastic paraplegia. American Journal of Medical Genetics Part A, 176(2), pp.421-425.

Duran, D., Messina, R.D., Beslow, L.A., Montejo, J.D., Karimy, J.K., Gavankar Furey, C., Sheridan, A.D., Sze, G., Yarman, Y., DiLuna, M.L. and Kahle, K.T., 2017. Malignant Cerebellar edema subsequent to accidental prescription opioid Intoxication in Children. Frontiers in neurology, 8, p.362.

Undergrad University of Wisconsin-Madison, BS, 2020
Year MD/PhD 2, JeffMD Phase 1, SKMC 2
Mentor TBD
PhD Program TBD
Research Interests I am interested in cancer biology, especially mechanisms related to tumor metastasis and tumor microenvironment.
Anticipated Residency Medical Oncology
Hobbies/Interests MI enjoy classical music (three composers that I like most are Wieniawski, Paganini, and Beethoven). I kind of know how to play piano and Guqin (a Chinese instrument). I also like cooking/baking, watching Korean dramas, and hiking.
Favorite Places/Things
to Do in Philadelphia
TBD
Honors/Awards

Undergraduate:

2019 CPRIT-CURE Summer Undergraduate Program, MDA Cancer Center             

2019-2020 Hilldale Undergraduate Research Fellowship, UW-Madison

2019-2020 Anna L. Rowe Scholarship, CALS, UW-Madison      

2018-2019 Sophomore Research Fellowship, UW-Madison

2018 Summer Undergraduate Research Fellowship, Mayo Clinic

2017-2018 Dorothy Strong Scholarship, CALS, UW-Madison

Publications

Undergraduate:

Tanimura N., Liao R., Wilson GM., Dent MR., Cao M., Burstyn JN., Hematti P., Liu X., Zhang Y., Zheng Y., Keles S., Xu J., Coon JJ., Bresnick EH. 2018. “Gata/Heme Muti-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism.”, Developmental Cell, 46(5):581-594.

Soukup AA., Zheng Y., Mehta C., Wu J., Liu P., Cao M., Hofmann I., Zhou Y., Zhang J., Johnsom KD., Choi K., Keles S., Bresnick EH. 2019. “Single Nucleotide Human Disease Mutation Inactivates a Blood-Regenerative Enhancer.”, Journal of Clinical Investigation,129(3):1180-1192.

Undergrad Yale College, B.S. Molecular Biophysics & Biochemistry, 2018
Year MD/PhD 2, JeffMD Phase 1, SKMC 2
Mentor TBD
PhD Program TBD
Research Interests I am currently interested in translational cancer research using genomic & bioinformatic methods to identify novel molecular targets and develop improved therapies.
Anticipated Residency Currently interested in surgery; looking forward to exploring different specialties during medical school
Hobbies/Interests Electric & acoustic guitar (jazz, blues, funk, and other genres too) and music production, playing squash (the sport, not the vegetable), watching soccer, cooking, traveling.
Favorite Places/Things
to Do in Philadelphia
Looking forward to exploring new restaurants and places to hang out in Philly during my first year!
Honors/Awards Yale Science Scholar Research Fellowship
Publications

Postgraduate:

Johnson KK, Ip K, Rubino S, Leung C, Nawaf CB, Martin TV, Hesse DG. Surgical site infection in robot-assisted radical cystectomy vs. open radical cystectomy. Selected for presentation at The New England Section of The American Urological Association, Annual Meeting, Burlington, Vermont. September 2020.

Ip K, Thomas MA, Khunte A, Behar KL, de Graaf RA, De Feyter HM. Mapping of exogenous choline uptake in brain tumors in vivo using Deuterium Metabolic Imaging (DMI). Selected for oral presentation, International Society for Magnetic Resonance in Medicine, Virtual Conference. August 2020.

Undergraduate:

Saeyeldin A, Zafar MA, Velasquez CA, Ip K, Gryaznov A, Brownstein AJ, Li Y, Rizzo JA, Erben Y, Ziganshin BA, Elefteriades JA. Natural history of aortic root aneurysms in Marfan syndrome. Ann Cardiothorac Surg 6, 625–632 (2017).

Fan C, Ip K, Söll D. Expanding the Genetic Code of Escherichia coli with Phosphotyrosine. FEBS Lett. 590(17), 3040-3047 (2016).

De Feyter HM, Behar KL, Rao JU, Madden-Hennessy K, Ip K, Hyder F, Drewes LR, Geschwind J-F, de Graaf RA, Rothman DL. A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth. Neuro Oncol. 18(8), 1079-1087 (2016).

Miller C, Bröcker MJ, Prat L, Ip K, Chirathivat N, Feiock A, Veszprémi M, & Söll D. A synthetic tRNA for EF-Tu mediated selenocysteine incorporation in vivo and in vitro. FEBS Lett. 589(17), 2194-2199 (2015).

Undergrad Hofstra University, B.A., Economics, 2017
Year MD/PhD 2, JeffMD Phase 1, SKMC 2
Mentor TBD
PhD Program TBD
Research Interests I previously studied a novel combination treatment for use in patients with pancreatic, breast, and endometrial cancers. This work is currently in the process of being translated into patient care, and it will hopefully be the foundation for multiple, innovative clinical trials. During my MD/PhD years, I intend to continue studying novel therapeutics – and underlying cancer mechanisms – to eventually create novel therapeutics for patients. 
Anticipated Residency Hematology/Oncology
Hobbies/Interests I love watching baseball – I’m a die-hard Yankees fan
Favorite Places/Things
to Do in Philadelphia
The food in Philadelphia is phenomenal! I love going out to eat all the restaurants! 
Honors/Awards

Undergraduate: Presidential Scholarship, Hofstra University, 2014-2017

Graduate: Outstanding Academic Accomplishment by a Master’s Student (thesis award)

Publications

Ralff, M.D., Jhaveri, A., Ray, J.E., Zhou, L., Lev, A., Campbell, K.S., Dicker, D.T., Ross, E.A. and El-Deiry, W.S., 2020. TRAIL receptor agonists convert the response of breast cancer cells to ONC201 from anti-proliferative to apoptotic. Oncotarget11(42), p.3753.

Prabhu, V.V., Morrow, S., Kawakibi, A.R., Zhou, L., Ralff, M., Ray, J., Jhaveri, A., Ferrarini, I., Lee, Y., Parker, C. and Zhang, Y., 2020. ONC201 and imipridones: Anti-cancer compounds with clinical efficacy. Neoplasia22(12), pp.725-744.

Lan, X., Jhaveri, A., Cheng, K., Wen, H., Saleem, M.A., Mathieson, P.W., Mikulak, J., Aviram, S., Malhotra, A., Skorecki, K. and Singhal, P.C., 2014. APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability. American Journal of Physiology-Renal Physiology307(3), pp.F326-F336.

Lan, X., Cheng, K., Chandel, N., Lederman, R., Jhaveri, A., Husain, M., Malhotra, A. and Singhal, P.C., 2013. High glucose enhances HIV entry into T cells through upregulation of CXCR4. Journal of leukocyte biology94(4), pp.769

Undergrad Penn State, Pre-Medical-Medical (PMM), 2020
Year MD/PhD 2, JeffMD Phase 1, SKMC 2
Mentor TBD
PhD Program TBD
Research Interests My previous research examined how copy number variants (CNVs), which are genomic deletions and duplications typically spanning multiple genes, affect gene dosage in patients and contribute to the pathogenesis of neurodevelopmental disorders such as autism, schizophrenia, and intellectual disability. I am interested in further pursuing neuroscience research, especially in the context of translational work, but I’m certainly open to exploring other exciting disciplines like immunology and cancer biology.
Anticipated Residency TBD
Hobbies/Interests I'm really passionate about soccer, and you'll find me either playing it or watching it whenever I can.  My other hobbies include reading about US history and staying informed about/discussing current events. I also like to think I have a green thumb and love growing everything from succulents to orchids to even carnivorous plants!
Favorite Places/Things
to Do in Philadelphia
I still have a lot of exploring to do, but I enjoy the food scene here, especially at the Reading Terminal Market. I also love visiting different historical sites and museums as well as going for runs near the Schuylkill and Delaware rivers. 
Honors/Awards

Ruth E. Duffy Pre-Medicine Endowment (2019)

Eberly College of Science Ovadia Scholarship (2019)

President Sparks Award (2019)

Rodney A. Erickson Discovery Grant (2019)

Evan Pugh Senior Scholar Award (2020)

Publications

Yusuff T, Jensen M, Yennawar S, Pizzo L, Karthikeyan S, Gould DJ, Sarker A, Gedvilaite E, Matsui Y, Iyer J, Lai ZC, Girirajan S. (2020) Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development. PLOS Genetics 16(6): e1008792. https://doi.org/10.1371/journal.pgen.1008792

Pizzo L, Lasser M, Yusuff T, Jensen M, Ingraham P, Huber E, Singh MD, Monahan C, Iyer J, Desai I, Karthikeyan S, Weiner A, Krishnan A, Rolls M, Lowery LA, Girirajan S. Functional assessment of the “two-hit” model for neurodevelopmental defects in Drosophila and X. laevis models of 16p12.1 deletion. (Under Review, Genome Research)

Undergrad Cornell University, BA, 2017
Year MD/PhD 2, JeffMD Phase 1, SKMC 2
Mentor TBD
PhD Program TBD
Research Interests I have previously studied chemoresistance in ovarian cancers, and I would like to continue in women’s health research during my MD/PhD. I am interested in breast, ovarian, and cervical cancers, as well as infertility.
Anticipated Residency Obstetrics and Gynecology
Hobbies/Interests I love baking, reading, and writing poetry. I also enjoy trying new restaurants and seeing live music with friends!
Favorite Places/Things
to Do in Philadelphia
Philly has fantastic museums! Some of my favorites are the Barnes Foundation, which has one of the world’s largest impressionist collections, and the Mutter Museum, which documents medical history through specimens and medical tools. I love the collection of over 2,000 swallowed objects removed by one surgeon!
Honors/Awards Undergraduate: Society of American Naturalists Ruth Patrick Student Poster Award
Publications Fukumoto, T., Magno, E., & Zhang, R. (2018). SWI/SNF complexes in ovarian cancer: mechanistic insights and therapeutic implications. Molecular Cancer Research, 16 (12); 1-7. DOI: 10.1158/1541- 7786.MCR-18-0368