MD/PhD Program

College

  • Center City Campus
  • Sidney Kimmel Medical College

Degree Earned

  • Doctorate

Program Length
8 years

Program Type

  • On Campus

Prerequisites
Baccalaureate degree 
Learn more

Leadership

Name: Scott A. Waldman, MD, PhD, FCP
Position: Director, MD/PhD Program

1020 Locust Street
Jefferson Alumni Hall, 368
Philadelphia, PA 19107-5244

Telephone: 215-955-6086

Leadership

Name: Manuel Covarrubias, MD, PhD
Position: Director, MD/PhD Program

233 South 10th Street
Bluemle Life Sciences Building, 221A
Philadelphia, PA 19107

Telephone: 215-503-4341

Program Information

Name: Danielle Park
Position: Administrative Director
Telephone: 215-503-0164

Meet Our Current Students

Undergrad   University of Pittsburgh, BS, 2013
Year   MD/PhD 8, JeffMD Phase 3, SKMC 4
Mentor   Angelo Lepore, PhD
PhD Program

Research Interests
 

Neuroscience

Currently, I am investigating strategies to restore independent inspiratory breathing after cervical spinal cord injury. In the future, I would like to pursue clinical training in pediatric neurology and a research career studying leukodystrophies and white matter disorders in children.

Hobbies/Interests   My main interest outside of science is my dog, Thor. I also enjoy the Wissahickon trails and a good book.
Favorite Places/Things
to Do in Philadelphia
  Exploring the food scene in Philly is my favorite thing to do when I’m not in the lab or studying. I especially like all the BYOB gems throughout the city.
Honors/Awards   Ruth L. Kirschstein NRSA Pre-Doctoral F30 Fellowship
Neurodevelopmental Disabilities Scholarship, Child Neurology Foundation
Trainee Professional Development Award, Society for Neuroscience
Grant-In-Aid of Research Award, Sigma Xi1st Place Graduate Student Poster Award, 37th Meeting of the Philadelphia Chapter of the Society for Neuroscience, 2018
1st Place Graduate Student Poster Award, 36th Meeting of the Philadelphia Chapter of the Society for Neuroscience, 2017
Outstanding Poster Prize, TJU’s Sigma Xi Student Research Day, 2017
Outstanding Poster Prize, TJU’s Sigma Xi Student Research Day, 2016
The Fredric Rieders Renaissance Foundation Graduate Student Recognition Award
Adelaide M. Delluva Student Travel Award, Association for Women in Science, Philadelphia
Hobart Amory Hare Medical Honor Society, Thomas Jefferson University
Phi Beta Kappa Honor Society, University of Pittsburgh
Amgen Scholars Summer Undergraduate Research Program at the University of California, Berkeley
The Norman H. Horowitz Undergraduate Research Fellowship, University of Pittsburgh
The Samuel D. Colella Award for Summer Undergraduate Research, University of PittsburghOutstanding Freshman Biology Award, University of Pittsburgh
 Publications  

Charsar BA, Goldberg EM. Polymicrogyria and intractable epilepsy in siblings with Knobloch syndrome and homozygous mutation of COL18A1. Pediatric Neurology. 2017. DOI: 10.1016/j.pediatrneurol.2017.08.003.

Charsar BA, Urban MW, Lepore AC. Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury. Experimental Neurology 2016. DOI: 10.1016/j.expneurol.2016.08.009.

Coombes JL, Charsar BA, Han SJ, Halkias J, Chan SW, Koshy AA, Striepen B, Robey EA. Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread. Proceedings of the National Academy of Sciences. 2013; 110:1913-1922.

Hainer SJ, Charsar BA, Cohen SB, Martens JA. Identification of spt16 mutants that are defective for transcription-coupled nucleosome occupancy in Saccharomyces cerevisiaeG3: Genes, Genomics, and Genetics. 2012; 2:555-567.

Undergrad   Brown University, ScB/ScM 
Year   MD/PhD 8, JeffMD Phase 3, SKMC 4
Mentor   Makarand Risbud, PhD

PhD Program

Research Interests

 

Anticipated Residency

 

Cell Biology and Regenerative Medicine

My thesis investigated the role of cytokine signaling in intervertebral disc matrix homeostasis. In the future, I plan to study the role of inflammation in critical care medicine. 

Internal Medicine

Hobbies/Interests  

Outside of being a student, I play roller derby and classical guitar.

Favorite Places/Things
to Do in Philadelphia
  Philadelphia has amazing restaurants. Most of my favorite things in Philadelphia involve food. Other than eating, I enjoy roller skating along the Schuykill River, catching comedy shows, and reading outside.  
Honors/Awards  

F30 Ruth L. Kirschstein National Research Service Award, NIH/NIAMS

Scholarly Inquiry with Distinction

Spine Research Podium Presentation Award, Orthopaedic Research Society

Tissue Engineering Podium Presentation Award, Philadelphia Spine Research Society

Finalist and Grant Winner, Rhode Island Business Plan Competition

 Publications  

Gorth, D.J., Ottone, O.K., Shapiro, I.M., Risbud, M.V. 2020, Differential effect of long-term systemic exposure of TNFα on health of the annulus fibrosus and nucleus pulposus of the intervertebral disc, Journal of Bone and Mineral Research. Apr; 35(4):725-737.

Gorth, D.J., Shapiro, I.M., Risbud, M.V. 2019, A new understanding of the role of IL-1 age-related intervertebral disc degeneration in a murine model, Journal of Bone and Mineral Research. Aug; 34(8):1531-1542.

Gorth, D.J., Shapiro, I.M., Risbud, M.V. 2018, Transgenic mice overexpressing human TNF-a experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration, Cell Death and Disease. Dec; 10(1):7.

Gorth, D.J., Shapiro, I.M., Risbud, M.V. 2015, Discovery of the Drivers of Inflammation Induced Chronic Low Back Pain: From Bacteria to Diabetes, Discovery Medicine. Oct; 20(110): 177-84.

Gorth, D.J., Losthstein, K.E., Chiaro, J.A., Farrell, M.F., Dodge, G.R., Elliott, D.M., Malhotra, N.R., Mauck, R.L., Smith, L.J., 2015, Hypoxic regulation of functional extracellular matrix elaboration by nucleus pulposus cells in long-term agarose culture, Journal of Orthopeadic Research. May; 33 (5): 747-54.

Smith, L.J., Gorth, D.J., Showalter, B.L., Chiaro, J.A., Beattie, E.E., Elliott, D.M., Mauck, R.L., Chen, W., Malhotra, N.R., 2014, In vitro characterization of a stem-cell-seeded triple-interpenetrating-network hydrogel for functional regeneration of the nucleus pulposus, Tissue Eng Part A., Jul;20(13-14):1841-9.

Gorth, D.J., Martin, J.T., Dodge, G.R., Elliott, D.M., Malhotra, N.R., Mauck, R.L., Smith, L.J. 2014, In vivo retention and bioactivity of IL-1ra microspheres in the rat intervertebral disc: a preliminary investigation, Journal of Experimental Orthopaedics, Dec; 1: 15.

Martin, J.T., Gorth, D.J., Beattie, E.E., Harfe, B.D., Smith, L.J., Elliott, D.M., 2013, Needle Puncture Injury Causes Acute and Long-Term Mechanical Deficiency in a Mouse Model of Intervertebral Disc Degeneration, J Orthop Res., 31(8):1276-82.

Gorth, D.J., Mauck, R.L., Chiaro, J.A., Mohanraj, B., Hebela, N.M., Dodge, G.R., Elliott, D.M., Smith, L.J., 2012, IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro, Arthritis Research and Therapy., Aug 3;14(4):R179.

Gorth, D.J., Rand, D.M. and Webster, T.J., 2011, Silver nanoparticle toxicity in Drosophila: size does matter.  International Journal of Nanomedicine, 6: 343-350.

Gorth, D.J. and Webster, T.J., 2010, Matrices for Tissue Engineering and Regenerative Medicine. In Lysaght M. and Webster, T. (Eds.), Biomaterials for artificial organs. Cambridge: Woodhead Publishing Ltd.

Kittleson, M.M., Gorth, D.J., Williams, P.N., Watto, M.F., 2020 “#230 Kittleson Rules Heart Failure”. The Curbsiders Internal Medicine Podcast. https://thecurbsiders.com/podcast/230.

Weimer, M.B., Chan, C.A., Taranto, N.T., Gorth, D.J., Williams, P.N., Brigham, S.K., Okamoto, E., Watto, M.F., 2020 “#224 Hospital Addiction Medicine”. The Curbsiders Internal Medicine Podcast. https://thecurbsiders.com/podcast/224.

Essien, U.R., Ganatra, R.B., Okamoto, E., Roberts, S.P., Gorth, D.J., Watto, M.F., 2020 “#223 Hot COVID Cakes: COVID19 Disparities, Steroids, Hormones for Depression, Probiotics”. The Curbsiders Internal Medicine Podcast. https://thecurbsiders.com/podcast/223.

Narewski, E., Gorth, D.J., Kus, N., Madnick, D., Wikoff, P., Williams, P.N., Jyang, E., Brigham, S.K., Watto, M.F., 2020 “#221 Interstitial Lung Disease with Erin Narewski DO”. The Curbsiders Internal Medicine Podcast. https://thecurbsiders.com/podcast/221.

 

Gorth, D.J., Ganatra, R.B., Okamoto, E., Roberts, S.P., Watto, M.F., 2020 “#217 COVID Cakes 4 the Fourth”. The Curbsiders Internal Medicine Podcast. https://thecurbsiders.com/podcast/217.

Undergrad   St. Olaf College, BS, 2013
Year   MD/PhD 8, JeffMD Phase 3, SKMC 4
Mentor   Isidore Rigoutsos, PhD

PhD Program

Research Interests

 

Anticipated Residency

 

Neuroscience

My long-term interests involve leveraging bioinformatic, high throughput “-omic”, and machine learning approaches in the research of neuropsychiatric disorders.

N/A

Hobbies/Interests   I love both playing and watching soccer and basketball, hiking and camping, the board game Diplomacy, and playing guitar. I’m also extremely passionate about extending my list of movies and TV shows watched to infinity and beyond.
Favorite Places/Things
to Do in Philadelphia
  In free time, I like to: run the Schuylkill river trail, catch a 76ers or Union game, walk around the art museum, get lost in Reading Terminal Market, or try out one of Philly’s many amazing restaurants.
Honors/Awards   Phi Beta Kappa, Distinction in Computer Science at St. Olaf College, Fredric Rieders Family Renaissance Foundation Graduate Student Recognition Award 2017, Hobart Amory Hare Honor Society, Sigma Xi Research Day Student Poster Award 2018
 Publications  

Pliatsika, V, Loher, P, Magee, R, Telonis, AG, Londin, E, Shigematsu, M, Kirino, Y, Rigoutsos, I. MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects. Nucleic Acids Res. 2018; 46 (D1):D152-D159. doi: 10.1093/nar/gkx1075. PubMed PMID:29186503 PubMed Central PMC5753276.

Pliatsika, V, Loher, P, Magee, R, Telonis, AG, Londin, E, Shigematsu, M, Kirino, Y, Rigoutsos, I. MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects. Nucleic Acids Res. 2018; 46 (D1):D152-D159. doi: 10.1093/nar/gkx1075. PubMed PMID:29186503 PubMed Central PMC5753276.

Magee, R, Telonis, AG, Cherlin, T, Rigoutsos, I, Londin, E. Assessment of isomiR Discrimination Using Commercial qPCR Methods. Noncoding RNA. 2017; 3 (2): doi: 10.3390/ncrna3020018. PubMed PMID:28730153 PubMed Central PMC5514785.

Telonis, AG, Magee, R, Loher, P, Chervoneva, I, Londin, E, Rigoutsos, I. Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types. Nucleic Acids Res. 2017; 45 (6):2973-2985. doi: 10.1093/nar/gkx082. PubMed PMID:28206648 PubMed Central PMC5389567.

Magee, R, Loher, P, Londin, E, Rigoutsos, I. Threshold-seq: a tool for determining the threshold in short RNA-seq datasets. Bioinformatics. 2017;33 (13):2034-2036. doi: 10.1093/bioinformatics/btx073. PubMed PMID:28203700 PubMed Central PMC5870860.

Undergrad   University of Pittsburgh, BS, 2010
Year   MD/PhD 8, JeffMD Phase 3, SKMC 4
Mentor   James Schwaber, PhD

PhD Program

Research Interests

Anticipated Residency

 

Neuroscience

Substance use disorders, gut microbiome, gut-brain axis.

Psychiatry

Hobbies/Interests   Hockey, yoga
Favorite Places/Things
to Do in Philadelphia
  Farmer’s markets.
Honors/Awards   Biomedical Sciences Alumni Travel Fellowship (Thomas Jefferson University, 2019)
Student Hotspotting Program Graduate (Thomas Jefferson University, 2019) https://www.jefferson.edu/about/news-and-events/2019/7/student-hotspotters-work-to-reduce-healthcare-costs.html
Undergraduate Instructor – Medical Genetics (East Falls Campus, 2017)
Leadership Live Graduate (Thomas Jefferson University, 2016)
AOA Research Symposium, Runner-Up Best Poster (2015)
JeffHOPE Video Director and Producer (2015) https://www.youtube.com/watch?v=ubNkf35yKQ0
AOA Research Symposium, Second Place Podium Talk (2014)
Hobart Amory Hare Honor Society (2014)
Dubbs Scholar MD/PhD Fellowship Award (Thomas Jefferson University, 2013)
Chancellor’s Undergraduate Research Fellowship (2010)
 Publications  

O’Sullivan, S.J., Reyes, B.A.S., Vadigepalli, R., Van Bockstaele, E.J., Schwaber, J.S. (2019) Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence. J Vis Exp. 10:3791/60612.

O’Sullivan SJ, Malahias E, Park J, Srivastava A, Reyes BAS, Gorky J, Vadigepalli R, Van Bockstaele EJ, Schwaber JS. Single-cell glia and neuron gene expression in the central amygdala in opioid withdrawal suggests inflammation with correlated gut dysbiosis. 2019. Frontiers in Neuroscience, 13, 665

Staehle MM, O’Sullivan SJ, Vadigepalli R, Kernan K, Gonye GE, Ogunnaike BA, Schwaber JS. Diurnal patterns of gene expression in the dorsal vagal complex and the central nucleus of the amygdala – non-rhythm-generating brain regions. 2019. Frontiers in Neuroscience, In Press.

Park J, Zhu H, O’Sullivan SJ, Ogunnaike BA, Weaver DR, Schwaber JS, Vadigepalli, R. Single-cell transcriptional analysis reveals novel neuronal phenotypes and interaction networks involved in the central circadian clock. 2016. Frontiers in Neuroscience, 10, 481

Undergrad   Lehigh University, BS, 2011
Year   MD/PhD 8, JeffMD Phase 3, SKMC 4
Mentor   Le Ma, PhD

PhD Program

Research Interests

 

Anticipated Residency

 

Neuroscience

I study the role of microtubule-associated proteins in determining axon morphology during development.

 

N/A

Hobbies/Interests   Going to restaurants, watching movies, video games, board games like Diplomacy. Ancient history and pointless trivia (the two things are related actually). I like puns too.
Favorite Places/Things
to Do in Philadelphia
  Going to Reading Terminal and getting lots of food and getting annoyed by all the slow walkers.
Honors/Awards   Phi Beta Kappa, President’s Scholarship
 Publications  

Tymanskyj, S. R., Yang, B., Falnikar, A., Lepore, A. C., & Ma, L. (2017). MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglia Neurons. Journal of Neuroscience, 3260-16. PMCID: PMC5299575

Yang, B., Curran, B.M., & Tymanskyj, S.R. (2017). A Role for AnkyrinG in Maturation and Maintenance of the Nodes of Ranvier. Journal of Neuroscience, 5796-5797.

Undergrad   Villanova University, BSH, BS, BA, 2014
Year   MD/PhD 7, JeffMD Phase 3, SKMC 3
Mentor   Ulhas Naik, PhD
PhD Program

Research Interests
 

Cell Biology & Regenerative Medicine

Our lab overall focuses on the role of platelets in cardiovascular disease. More specifically, I’m investigating the role of platelets in stroke and remote organ injury.

Hobbies/Interests   Volunteering at the pediatric department, spending time with family and friends, reading, making no-bake desserts
Favorite Places/Things
to Do in Philadelphia
  Museum hopping/visiting the amazing historical landmarks scattered around the city; Having brunch with friends (V Street is my favorite place so far)
Honors/Awards   National Pathology Honor Society (2016)
Hobart Amory Hare Medical Honor Society (2016)
Sigma Xi Poster Award (2018)
JCBS Alumni Association Travel Fellowship Award (2018)
 Publications  

Iosue, C. L., Attanasio, N., Shaik, N. F., Wykoff, D. D. (2016). Partial Decay of Thiamine Signal Transduction Pathway Alters Growth Properties of Candida glabrataPLoS ONE, 11(3). PMC4807840. (Undergraduate)

Nahas, J.V., Iosue, C. L., Shaik, N. F., and Wykoff, D. D. (2018) Dynamic Changes in Yeast Phosphatase Families Allow for Specialization in Phosphate and Thiamine Starvation. G3 (Bethesda), Epub. PMID: 29748198 (Undergraduate)

Undergrad   Yale University, BS, 2014
Year   MD/PhD 7, JCLS 5
Mentor   Richard J. Smeyne, PhD
PhD Program

Research Interests
 

Neuroscience

Neurodegeneration, Neurodevelopment, Environmental Enrichment, Social Isolation.

Hobbies/Interests   Travel, Foods, Puzzles, Soccer, Billiards, Learning new language  
Favorite Places/Things
to Do in Philadelphia
  Get foods/ice-cream/bubble tea in Chinatown, visit the awesome museums on the Benjamin Franklin Parkway, walk around City Hall, Penn’s Landing and Spruce Street Harbor, run along the Schuylkill River trail, play pool at Buffalo Billiards.
Honors/Awards  

Hobart Amory Hare Honor Society, Pathology Honor Society, 1st rank in Neuroscience Course, Honorable mention in the 9th Annual Annenberg Anatomy Competition.

Undergraduate: Friends of Todai Global Leadership Award, Science, Technology, and Research Scholar (STARS II) research fellowship, Yale College Dean’s Research fellowship, Charles E. Jones Scholarship

 Publications  

A.T. Issa, K. Miyata, V. Heng, K.D. Mitchell, A.V. Derbenev. (2012). Increased neuronal activity in the OVLT of Cyp1a1-Ren2 transgenic rats with inducible Ang II-dependent malignant hypertension. Neuroscience Letters, 519 (1), 26–30.

C. Kubera, A.L. Hernandez, V. Heng, A. Bordey. (2012). Transient mGlu5R inhibition enhances the survival of granule cell precursors in the neonatal cerebellum. Neuroscience, 219 (6), 271–279.

Undergrad   University of Maryland - College Park, BS, 2014
Year   MD/PhD 7, JCLS 5
Mentor   Scott Waldman, MD, PhD
PhD Program

Research Interests
 

Cell Biology & Regenerative Medicine

Genetic and other early transformational events in colon cancer

Hobbies/Interests   Gardening, woodworking, fostering kittens and pawning them off on co-workers
Favorite Places/Things
to Do in Philadelphia
  Saturday morning farmer’s market in Clark Park
Honors/Awards  

Ruth L. Kirschstein National Research Service Award (NIH, 2018)

Pre-doctoral Fellowship in Pharmacology/Toxicology - PhRMA Foundation (2017)
Dubbs Scholar MD/PhD Fellowship Award – Thomas Jefferson University (2014)
Undergraduate Researcher of the Year Award – University of Maryland (2014)
HHMI Undergraduate Research Fellowship – University of Maryland (2012)
Biomedical Engineering Summer Internship Program (BESIP) Fellowship – NIH (2012)
Solar Decathlon Competition, 1st Place Entry (“WaterShed”) – US Department of Energy (2011)
Banneker-Key Full Academic Scholarship – University of Maryland (2009)
Maryland Distinguished Scholar Academic Scholarship – State of Maryland (2009)

 Publications  

Manthe RL, Rappaport JA, Long Y, Solomon M, Veluvolu V, Hildreth M, Gugutkov D, Marugan J, Zheng W, Muro S. delta-Tocopherol Effect on Endocytosis and its Combination with Enzyme Replacement Therapy for Lysosomal Disorders: a New Type of Drug Interaction? J Pharmacol Exp Ther 2019.

Bashir B, Merlino DJ, Rappaport JA, Gnass E, Palazzo JP, Feng Y, Fearon ER, Snook AE, Waldman SA. Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia. Hum Pathol 2019;87:103-114.

Rappaport JA, Waldman SA. The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. Front Oncol 2018;8:299.

Kraft CL, Rappaport JA, Snook AE, Pattison AM, Lynch JP, Waldman SA. GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress. Oncotarget 2017;8:102923-102933.

Li P, Wuthrick E, Rappaport JA, Kraft CL, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA. GUCY2C signaling opposes the acute radiation-induced GI syndrome. Cancer Res 2017;77:5095-5106. Cover article

Aka AA*, Rappaport JA*, Pattison AM, Sato T, Snook AE, Waldman SA. Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer. Expert Rev Clin Pharmacol 2017;10:549-557. *Authors contributed equally

Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA. Intestinal enteroids model guanylate cyclase C-dependent secretion induced by heat-stable enterotoxins. Infect Immun 2016;84:3083-91.

Rappaport J*, Manthe RL*, Solomon M, Garnacho C, Muro S. A comparative study on the alterations of endocytic pathways in multiple lysosomal storage disorders. Mol Pharm 2016;13:357-368. *Authors contributed equally

Rappaport J, Papademetriou J, Muro S. Drug Delivery Through the Endo-Lysosomal Route. In: Drug Delivery Across Physiological Barriers, Muro S. (Ed.) Pan Stanford Publishing. 2016

Rappaport J, Manthe RL, Garnacho C, Muro S. Altered clathrin-independent endocytosis in type A Niemann-Pick disease cells and rescue by ICAM-1-targeted enzyme delivery. Mol Pharm 2015;12:1366-1376.

Rappaport J, Garnacho C, Muro S. Clathrin-mediated endocytosis is impaired in type A-B Niemann-Pick disease model cells and can be restored by ICAM-1-mediated enzyme replacement. Mol Pharm 2014;11:2887-95.

Hsu J, Rappaport J, Muro S. Specific binding, uptake, and transport of ICAM-1-targeted nanocarriers across endothelial and subendothelial cell components of the blood-brain barrier. Pharm Res 2014;31:1855-66.

Undergrad   University of Pittsburgh, BS, 2013
Year   MD/PhD 6, JCLS 4
Mentor   Adam Snook, PhD
PhD Program

Research Interests
 

Immunology & Microbial Pathogenesis

Immunology, cancer immunology, immunotherapy

Hobbies/Interests   Cooking, fingerstyle guitar, running
Favorite Places/Things
to Do in Philadelphia
  Trying new restaurants, running along the Schuylkill River
Honors/Awards   NIH Postbaccalaureate Intramural Research Training Award
University of Pittsburgh Scholar
Ossip Award for Excellence in Undergraduate Writing
 Publications  

Flickinger, J.C., Jr., Rodeck, U., Snook, A.E. 2018. Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress. Vaccines (6): 48.

Magee, M.S., Abraham, T.S., Baybutt, T.R., Flickinger, J.C., Ridge, N.A., Marszalowicz, G.P., Prajapati, P., Hersperger, A.R., Waldman, S.A. and Snook, A.E. 2018. Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases. Cancer immunology research 6(5):509-516.

Kwong, B., Rua, R., Gao, Y., Flickinger, J., Wang, Y., Kruhlak, M.J., Zhu, J., Vivier, E., McGavern, D.B. and Lazarevic, V. 2017. T-bet-dependent NKp46(+) innate lymphoid cells regulate the onset of TH17-induced neuroinflammation. Nature Immunology 18(10), pp. 1117–1127.

Leeman JE, Flickinger JC Jr, Clump DA, Wegner RE, Heron DE, Burton SA, Mintz AH. Detection and Treatment of Small Brain Metastases Resulting from Renal Cell Carcinoma Predict Improved Survival After Stereotactic Radiosurgery.  2012. Journal of Radiation Oncology 7:107.

Flickinger JC Jr, Kim H, Kano H, Greenberger JS, Arai Y, Niranjan A Lunsford LD, Kondziola D, Flickinger JC Sr. 2012. Do Carbamazepine, Gabapentin, or Other Anticonvulsants Exert Sufficient Radioprotective Effects to Alter Responses from Trigeminal Neuralgia Radiosurgery? Int J Radiat Oncol Biol Phys. 15; 83(4): e501-6

Kim H, Bernard ME, Flickinger J, Epperly MW, Wang H, Dixon TM, Shields D, Houghton F, Zhang X, Greenberger JS. 2011. The Autophagy Inducing Drug Carbamazepine is a Radiation Protector and Mitigator. Int J Radiat Biol (10): 1052-60.

Undergrad University of Massachusetts Amherst, Biochemistry and Molecular Biology, 2014
Year MD/PhD 6, JCLS 4
Mentor Christine Eischen, PhD
PhD Program Immunology & Microbial Pathogenesis
Research Interests I am focusing on understanding the contributions of the DNA replication stress response to hematopoiesis and the effects of different replication stressors on developing hematopoietic cells.
Anticipated Residency Internal Medicine followed by a fellowship in Hematology & Oncology
Hobbies/Interests Hosting/attending potlucks, board games, reading/watching science fiction/fantasy and anime, spending time with the Jewish community
Favorite Places/Things
to Do in Philadelphia
Spruce Street Harbor, Schuylkill river trail and dog park
Honors/Awards

Ruth L. Kirschstein National Research Service Award, F30 Fellowship (2020)

Thomas Jefferson University Dean’s Student Collaborator Award (2016)

Northeast Undergraduate Research and Development Symposium Best Poster Presentation (2014)

Commonwealth Honors College Research Grant, University of Massachusetts Amherst (2013)

C.D. Youngren Research Scholarship, University of Massachusetts Amherst (2013)

Scientific Research Assistant Fellowship, University of Massachusetts Amherst (2011)

Eagle Scout Award, Boy Scouts of America (2009)

Publications Puccetti, M.V., Adams C.M., Kushinsky S., and Eischen C.M. Smarcal1 and Zranb3 Protect Replication Forks from Myc-Induced DNA Replication Stress. Cancer Research, 79:1612-23, 2019.(PMC6445766)

Undergrad   University of Delaware, BS, 2016
Year   MD/PhD 5, JCLS 3
Mentor   Scott Waldman, MD, PhD
PhD Program

Research Interests
 

Cell Biology & Regenerative Medicine

I’d really like to develop a therapy in the lab for patients that I work with in the clinic. For neurology, in particular, there are a lot of people suffering from diseases with no prospects for improvement, and I’d love to give them some hope. I think our understanding of the brain is going to grow and change drastically during our lifetime and I’d like to be part of figuring that out.
Hobbies/Interests   Cooking, Golf, Disc Golf, Animals, Any kind of game, and any kind of music
Favorite Places/Things
to Do in Philadelphia
  Music Bingo at Manny Brown’s on South St, Chilling with animals at the Zoo, Every booth at Reading Terminal Market
Honors/Awards   Biological Sciences Undergraduate Research Award (University of Delaware), Delaware Governor’s Bioscience Fellowship Award (University of Delaware)
 Publications   Joshua Barton, Archana Siddam, Deepti Anand, Salil A Lachke, Molecular Characterization of Two Human Lens Epithelial Cell Lines and Their Suitability to Study Function of Cataract Genes, 2018: (In Preparation)

Undergrad   Oberlin College, BA, 2015
Year   MD/PhD 5, JCLS 3
Mentor   Hushan Yang, PhD
PhD Program

Research Interests
 

Cell Biology & Regenerative Medicine

I am interested in neuroscience, specifically in how the nervous system interacts with the rest of the body, and in computation in general. My specific research interest has changed a lot (and multiple times) since entering medical school.

Hobbies/Interests   I like cooking, cycling and playing the guitar. This summer I’m hoping to grow a bonsai and a hydrangea bush.
Favorite Places/Things
to Do in Philadelphia
  I love watching the pups at the doggie park along the Schuylkill River Trail (it’s pronounced SKOOL-kul).
Honors/Awards   Elected into Phi Beta Kappa. May 2015
Awarded 1st place in the Sigma Xi Student Presentation Showcase 2015 (Undergraduate Division). Mar 2015
Elected into Sigma Xi, the Scientific Research Society. Mar 2015
Awarded the Robert Rich Grant from Oberlin College Robert Rich Foundation for outstanding research in the natural sciences. Mar 2015
Awarded the Pfizer-SOT Award to attend the Annual Society of Toxicology Meeting held in San Diego, CA (Mar 21 – Mar 26, 2015). Dec 2014  
 Publications  

Chong, W., Jiménez, J., McIIvin, M., Saito, M. A., & Kwakye, G. F. (2017). α-Synuclein Enhances Cadmium Uptake and Neurotoxicity via Oxidative Stress and Caspase Activated Cell Death Mechanisms in a Dopaminergic Cell Model of Parkinson’s Disease. Neurotoxicity research, 32(2), 231-246.

Undergrad   Ursinus College, BS, 2017
Year   MD/PhD 4, JCLS 2
Mentor   Andrew Aplin, PhD
PhD Program

Research Interests
 

Cell Biology & Regenerative Medicine

I am interested in translational cancer biology research. I like to understand molecular mechanisms of cancer that will help modulate future cancer therapies.

Hobbies/Interests   Outside of science I like to read science-fiction/fantasy books and play pick-up sports (give me any ball and I’ll chase after it). I also enjoy adventure trips with family and friends (hiking, camping, skiing, etc.).
Favorite Places/Things
to Do in Philadelphia
  I am a big fan of escape rooms and there are tons of new places in Philadelphia I have yet to explore. My favorite aspect of Philadelphia is being able to go to any corner of the street and finding a halal cart.
Honors/Awards  

Outstanding Research Student in Biology Award, Ursinus College, 2017

Medical Student Award from the Melanoma Research Foundation, February 2020

 Publications  

Loomis, C., Stephens, A., Janicot, R., Baqai, U., Drebushenko, L., & Round, J. (2020). Identification of MAGUK scaffold proteins as intracellular binding partners of synaptic adhesion protein Slitrk2. Molecular and Cellular Neuroscience, 103, 103465.

Teh, J. L., Purwin, T. J., Han, A., Chua, V., Patel, P., Baqai, U., ... & Aguirre-Ghiso, J. A. (2020). Metabolic adaptations to MEK and CDK4/6 co-targeting in uveal melanoma. Molecular Cancer Therapeutics.

Undergrad   Rutgers University, BA, 2014
Year   MD/PhD 4, JCLS 2
Mentor   Scott Waldman, MD, PhD
PhD Program

Research Interests
 

Neuroscience

I’m interested in studying neurodegenerative diseases, and have spent just under four years researching the potential of ketamine to treat depression and the possibility of endogenous factors in the brain to treat multiple sclerosis. Learning new techniques is exciting and rewarding, but I really appreciate being trained on how to approach new scientific problems.

Hobbies/Interests   As soon as I save enough money, I spend it on traveling somewhere new, and tend to contract food poisoning at least once every trip. I enjoy hiking, reading, and spending a good amount of time drinking coffee with my family and alcohol with my friends.
Favorite Places/Things
to Do in Philadelphia
  One of my routine activities in Philly is Muay Thai, which I practice a few times a week in Philly. No official fighting yet, though. I also love browsing the Italian market for the deal of the day (like a bucket of tangerines for $1), and when money is decent, I splurge on the best cappuccinos in the city at Function Coffee Labs.
Honors/Awards   Graduated magna cum laude from Rutgers
 Publications  

Alvarez JI, Kebir H, Cheslow L, Larochelle C, Charabati M, Prat A. JAML mediates monocytes and CD8 T cell migrations across the brain endothelium. Ann Clin Transl Neurol. 2015 Sep 29;2(11):1032-7.

Cheslow L, Alvarez JI. Glial-endothelial crosstalk regulates blood–brain barrier function. Current Opinion in Pharmacology. 2016 Feb;26:39-46.

Undergrad   Wellesley College, BA, 2013
Year   MD/PhD 4, JCLS 2
Mentor   Anjali Mishra, PhD
PhD Program

Research Interests
 

Cell Biology & Regenerative Medicine

After graduating from Wellesley College, I spent four years in a pulmonary and critical care research laboratory at Brigham and Women’s Hospital as a research assistant.  I worked on several projects relating to acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury. During my graduate years I hope to continue in this field of research, but I am excited to explore the many research opportunities at Jefferson.

Hobbies/Interests   At Jefferson I am on the board of the JeffLGBTQ student group, which organizes lectures and events for the TJU community. I also volunteer in the hospital with JeffReads, a group that encourages early literacy by providing new parents with books for their babies and fulfills cuddling needs in the intensive care nursery. In my spare time, I enjoy exploring restaurants in Philly (especially Dim Sum) and spending time outdoors.
Favorite Places/Things
to Do in Philadelphia
  Spruce St. Harbor Park is a great place to go during the summer for music, food, and fun! I also live near the Kawaii Kitty Café, where you can grab a coffee and play with cats!
Honors/Awards   Phi Beta Kappa, Wellesley College Durant Scholar, The Klein Prize in Neuroscience 2013 at Wellesley College
 Publications  

Englert JA, Cho MH, Lamb AE,  Shumyatcher M, Barragan-Bradford D, Basil MC, Higuera A, Isabelle C, ... Baron, RM. Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation. Respir Res. 2019;20(1):15. Published 2019 Jan 21. doi:10.1186/s12931-019-0981-6

Boudreault, F., Pinilla-Vera, M., Englert, J. A., Kho, A. T., Isabelle, C., Arciniegas, A. J., . . . Baron, R. M. (2017). Zinc deficiency primes the lung for ventilator-induced injury. JCI Insight, 2(11). doi:10.1172/jci.insight.86507

Englert, J. A., Macias, A. A., Amador-Munoz, D., Vera, M. P., Isabelle, C., Guan, J., . . . Baron, R. M. (2015). Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity. Anesthesiology, 123(2), 377-388. doi:10.1097/aln.0000000000000742

Undergrad   Yale College, BS, 2015
Year   MD/PhD 4, JCLS 2
Mentor   Noreen Hickok, PhD / Flemming Forsberg, PhD
PhD Program

Research Interests
 

Cell Biology & Regenerative Medicine

Past experience: Computational analysis, glucose metabolism, endocrinology;  Clinical research, acute kidney injury, acute interstitial nephritis, nephrology

Thesis research: Infection control, antibiotic prophylaxis, biomaterials, therapeutic ultrasound

Hobbies/Interests   Art and art history, traveling, photography.
Favorite Places/Things
to Do in Philadelphia
  I love trying new food (or revisiting old favorites) and going to art galleries or other cultural places. One of my favorites has been the Philadelphia Chinese Lantern Festival so far, which I believe is the largest one in the country!
Honors/Awards   Phase-1 Dean’s Student Research Prize (2019)
 Publications  

Moledina, D. G., Isguven, S., McArthur, E., Thiessen-Philbrook, H., Garg, A. X., Shlipak, M., ... & Parikh, C. R. (2017). Plasma monocyte chemotactic protein-1 is associated with acute kidney injury and death after cardiac operations. The Annals of thoracic surgery, 104(2), 613-620.

L. J. Delaney, M. Aliabouzar, S. Isguven, J. R. Eisenbrey, M. Fabiilli, N. J. Hickok, F. Forsberg.  Ultrasound-sensitive hydrogel for drug delivery applications.  J Ultrasound Med, vol. 39(Suppl), pp. S14, 2020.

Moledina, D. G., Isguven, S., McArthur, E., Thiessen-Philbrook, H., Garg, A. X., Shlipak, M., ... & Parikh, C. R. (2017). Plasma monocyte chemotactic protein-1 is associated with acute kidney injury and death after cardiac operations. The Annals of thoracic surgery, 104(2), 613-620.

Undergrad   University of California, Berkeley, BA, 2015
Year   MD/PhD 4, JCLS 2
Mentor   Matthew Dalva, PhD
PhD Program

Research Interests
 

Neuroscience

I’m primarily interested in neuroscience. I enjoy learning about the dynamics of synapses and neural circuits in different neurological states. Specifically, I want to study more about the neural circuit level basis for behavioral dysfunction exhibited in neurodevelopmental or neurodegenerative diseases such as Autism Spectrum Disorder or Alzheimer’s Disease.
Hobbies/Interests   I like to spend my time mostly outdoors which usually includes hiking, camping, or whatever activity I can do in nature. Sometimes when the Philly weather isn’t as nice to me, I’ll read a book, watch a movie, or play Settlers of Catan.
Favorite Places/Things
to Do in Philadelphia
  My opinion is that Philly is best known for its parks and its food. Favorite park: Wissahickon Valley. Favorite food: cheesesteaks from Ishkabibble’s.
Honors/Awards   I.L. Chaikoff Memorial Award (Berkeley)
 Publications   Hruska M, Henderson N, Le Marchand SJ, Jafri H, Dalva MB. (2018). Synaptic nanomodules underlie the organization and plasticity of spine synapses. Nat Neurosci. 21(5):671-682.

Elstrott J, Clancy KB, Jafri H, Akimenko I, Feldman DE. (2014). Cellular mechanisms for response heterogeneity among L2/3 pyramidal cells in whisker somatosensory cortex. J Neurophysiol. 112(2):233-48.

Undergrad Swarthmore College, BA, 2017
University of Pennsylvania, MS, 2018
Year MD/PhD 3, JCLS 1
Mentor Manuel Covarrubias, MD, PhD
PhD Program Neuroscience
Research Interests I am highly interested in the field of neuroscience. I have a broad interest in cellular and molecular as well as systems neuroscience with an emphasis on translational research. I am especially excited by interdisciplinary aspects which blend neuroscience with engineering, physics, and mathematics.
Anticipated Residency Neurosurgery
Hobbies/Interests I enjoy distance running and playing blues and jazz guitar. I am an avid reader and love to look at the stars with my telescope.
Favorite Places/Things
to Do in Philadelphia
Run along the Schuylkill River trail, read in one of Philly’s many cafés, and pick up coffee and donuts at Reading Terminal Market.
Honors/Awards Excellence in Social Impact Award (University of Pennsylvania, 2018)
Honors in NPLD Practicum (University of Pennsylvania, 2018)
Philadelphia Social Innovation Award (Finalist, 2017)
Anti-Poverty Solutions Summit (2016)
Foundation Grant Recipient (Swarthmore College, 2014)
Lang Opportunity Scholarship (Swarthmore College, 2013-2017)
Publications Sweid, A., Rahm, S. P., Das, S., Baldassari, M. P., Jabbour, P., Alexander, T. D.,...Tjoumakaris, S. (2019) Safety and Efficacy of Bilateral Flow Diversion for Treatment of Anterior Circulation Cerebral Aneurysms. World Neurosurgery. https://doi.org/10.1016/j.wneu.2019.07.115

Sweid, A., Head, J., Tjoumakaris, S., Xu, V., Shivashankar, K., Alexander, T. D., … Jabbour, P. (2019). Mechanical Thrombectomy in Distal Vessels: Revascularization Rates, Complications, and Functional Outcome. World Neurosurgery. https://doi.org/10.1016/j.wneu.2019.07.098
 
Alexander, T. D., McGovern, S. K., Leary, M., Abella, B. S., & Blewer, A. L. (2019). Association of state-level CPR training initiatives with layperson CPR knowledge in the United States. Resuscitation, 140, 9-15. doi:https://doi.org/10.1016/j.resuscitation.2019.04.037

Alexander, Tyler D., McGovern Shaun, K., Leary, M., Nadkarni, V., Abella Benjamin, S., & Blewer Audrey, L. (2018). Abstract 27: Implications of Legislative Efforts on Layperson CPR Education. Circulation, 138(Suppl_2), A27-A27. doi:10.1161/circ.138.suppl_2.27

Arbuckle, D. S., Howard, K. P., Alexander, T., & Crouch, C. (2017). Site-Directed Spin-Label EPR Spectroscopy of M2 Protein in Lipid Bilayers of Different Curvature Generation Propensity. Biophysical Journal, 112(3), 505a. doi:10.1016/j.bpj.2016.11.2733

Undergrad Penn State Premedical/Medical Accelerated Program, 2018
Year MD/PhD 3, JCLS 1
Mentor Matthew Dalva, PhD
PhD Program Neuroscience
Research Interests N/A
Anticipated Residency N/A
Hobbies/Interests N/A
Favorite Places/Things
to Do in Philadelphia
N/A
Honors/Awards Pre-Medicine Scholarship (2016, 2017)
Ruth E.Duffy Pre-Medicine Endowment (2016, 2017)
Mark and Sharon Robb Research Award (2017)
Dean’s List (2015, 2016, 2017)
Evan Pugh Senior Scholar Award (2017)
Euroscholar Scholarship Award (2018)
Publications

Zheng, W., Parry, M., Hou, X., Wang, H., Cain, R., Pei, Z., Guo, Z. “A gene therapy approach to directly convert striatal astrocytes into GABAergic neurons in a mouse model of Huntington’s disease” (In review)


Hruska, M., Cain, R., Dalva, M. “The nanoscale organization of glutamate receptor subtypes is optimized for synaptic function and plasticity” (manuscript in process)

Undergrad Brown University, BSc, 2016
Year MD/PhD 3, JCLS 1
Mentor Andrew Aplin, PhD
PhD Program Cell Biology & Regenerative Medicine
Research Interests I am interested in translational research in cancer biology, with an emphasis on cell signaling and cancer genetics
Anticipated Residency TBD
Hobbies/Interests In my spare time, I like reading and writing, and taking photographs. I also enjoy hiking, running, being outdoors, and traveling. I am also an avid polo player, having started playing as an undergraduate student.
Favorite Places/Things
to Do in Philadelphia
Checking out the Rodin Museum and Barnes Foundation, grabbing coffee in Rittenhouse and going for a walk around Graduate Hospital, hiking in Wissahickon Valley Park, eating pizza in Fishtown.
Honors/Awards

Hobart Amory Hare Medical Honor Society (Thomas Jefferson University, 2020)

James B. Erdmann Student Award for Excellence in Interprofessional Education and Collaborative Practice (Thomas Jefferson University, 2020)

Inducted to Sigma Xi: The Scientific Honor Society (Brown University, 2016)

Karen T. Romer Undergraduate Teaching and Research Award (Brown University, 2015)

BrownConnect LINK Award (Brown University, 2014)

Publications

Mitchell D.M., Caksa S., Joseph T., Bouxsein M.L., Misra M. Elevated HbA1c is associated with altered cortical and trabecular microarchitecture in girls with type 1 diabetes. Journal of Clinical Endocrinology & Metabolism. 2020 Apr; 105(4): 1-9. DOI: 10.1210/clinem/dgz221

Caksa S., Yuan A., Rudolph S. E., Yu E. W., Popp, K.L., Bouxsein M. L. Influence of soft tissue on bone density and microarchitecture measurements by high-resolution peripheral quantitative computed tomography. Bone. 2019 Jul; 124: 47-52. DOI: 10.1016/j.bone.2019.04.008

Popp K.L., Caksa S., Martinez-Betancourt A., Yuan A., Tsai J.N., Yu E.W., Bouxsein M.L. Cortical bone material strength index and bone microarchitecture in postmenopausal women with atypical femoral fractures. Journal of Bone and Mineral Research. 2019 Jan; 34 (1): 75-82. DOI: 10.1002/jbmr.3590

Unnikrishnan, G., Xu, C., Popp, K.L., Hughes J.M., Caksa, S., Guerriere K.I., Ackerman, K.E., Bouxsein, M.L., Reifman, J. Regional variation of bone density, microarchitectural parameters, and elastic moduli in the ultradistal tibia of young black and white men and women. Bone. 2018 Jul; 112: 194-201. DOI: 10.1016/j.bone.2018.05.004.

Rozental, T.D., Walley, K.C., Demissie, S., Caksa, S., Martinez-Betancourt, A., Parker, A. M. Tsai, J. N., Yu, E. W., Bouxsein, M. L. Bone material strength index as measured by impact microindentation in postmenopausal women with distal radius and hip fractures. Journal of Bone and Mineral Research. 2018 Apr; 33(4): 621-626. DOI: 10.1002/jbmr.3338

Mitchell, D.M., Caksa S., Yuan A., Bouxsein M.L., Burnett-Bowie, S.M., Misra M. Trabecular bone morphology correlates with skeletal maturity and body composition in healthy adolescent girls. Journal of Clinical Endocrinology & Metabolism. 2018 Jan; 103(1): 336-345. DOI: 10.1210/jc.2017-01785

Popp K.L., Hughes J.M., Martinez-Betancourt A., Scott M., Turkington V., Caksa S., Guerriere K.I., Ackerman K.E., Xu C., Unnikrishnan G., Reifman J., Bouxsein M.L. Bone mass, microarchitecture and strength are influenced by race/ethnicity in young adult men and women. Bone. 2017 Oct; 103: 200-208. DOI: 10.1016/j.bone.2017.07.014

Undergrad Cornell University, BA, 2017
Year MD/PhD 2, JeffMD Phase 2, SKMC 2
Mentor TBD
PhD Program TBD
Research Interests I'm currently interested in the field of neuroscience, specifically the molecular pathogenesis of neurodegenerative diseases.
Anticipated Residency TBD
Hobbies/Interests Baking/cooking, reading, watching soccer and cricket, learning new languages.
Favorite Places/Things
to Do in Philadelphia
I have a lot more exploring to do, but so far I'm enjoying exploring the varied food options, and the arts and music scene here!
Honors/Awards Tata Scholarship (Cornell University, 2013-2017)
Von Stade Fellowship (CSHL, 2016)
Burroughs Wellcome Fellowship (CSHL, 2016)
Publications

Martuscello RT, Kerridge CA, Chatterjee D, Hartstone WG, Kuo SH, Sims PA, Louis ED, Faust PL. Gene Expression Analysis of the Cerebellar Cortex in Essential Tremor. Neurosci Lett. 2020 Mar 16;721:134540.

Louis ED, Kerridge CA, Chatterjee D, Martuscello RT, Diaz DT, Koeppen AH, Kuo SH, Vonsattel JG, Sims PA, Faust PL. Contextualizing the Pathology in the Essential Tremor Cerebellar Cortex: A Patholog-omics Approach. Acta Neuropathol. 2019 Nov;138(5):859-876.

Lee PJ, Kerridge CA, Chatterjee D, Koeppen AH, Faust PL, Louis ED. A Quantitative Study of Empty Baskets in Essential Tremor and Other Motor Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2019 Feb 1;78(2):113-122.

Setiono FJ, Chatterjee D, Fuchs M, Perry KL, Thompson JR. The Distribution and Detection of Grapevine red blotch virus in its Host Depend on Time of Sampling and Tissue Type. Plant Dis. 2018 Nov;102(11):2187-2193.

Lee PJ, Kerridge CA, Chatterjee D, Koeppen AH, Faust PL, Louis ED. A Quantitative Study of Empty Baskets in Essential Tremor and Other Motor Neurodegenerative Diseases. J Neuropathol Exp Neurol. 2019 Feb 1;78(2):113-122.

Setiono FJ, Chatterjee D, Fuchs M, Perry KL, Thompson JR. The Distribution and Detection of Grapevine red blotch virus in its Host Depend on Time of Sampling and Tissue Type. Plant Dis. 2018 Nov;102(11):2187-2193.

Louis ED, Kerridge CA, Chatterjee D, Martuscello RT, Trujillo-Diaz D, Koeppen AH, Kuo SH, Vonsattel JG, Faust PL. Contextualizing the Changes in the Essential Tremor Cerebellum: A Comparative Postmortem Study (under review, Acta Neuropathol).

Martuscello RT, Kerridge CA, Chatterjee D, Hartstone WG, Kuo SH, Sims PA, Louis ED, Faust PL. Gene Expression Analysis of the Cerebellar Cortex in Essential Tremor (under review, Neurosci Lett)

Undergrad UC Davis, BS, 2018
Year MD/PhD 2, JeffMD Phase 2, SKMC 2
Mentor TBD
PhD Program TBD
Research Interests I have a love for molecular neuroscience, especially receptor biology. Working with Dr. Tian in undergraduate, I learned how to create receptor-based, protein sensors for imaging. I hope to apply this knowledge in a more clinical fashion as my career continues.
Anticipated Residency TBD
Hobbies/Interests It's a cliche, I know, but I really love eating. I usually cook, but there's only so much I can make. Thankfully, Philadelphia delivers a plethora of cuisine. I also love simply walking around the city and rock climbing at our local gym.
Favorite Places/Things
to Do in Philadelphia
Washington square is one of my favorite parks to just sit down and relax. South St. is always bustling with life and has some truly fantastic restaurants. Lastly it would be unfair to not recommend reading market to find great food and cooking ingredients.
Honors/Awards  
Publications

Undergraduate:

Singer GA, Loya FP, Lapsley WD, et al. Detection of Bartonella infection in pet dogs from Manila, the Philippines. Acta Trop. 2020;205:105277.

Weinborn-Astudillo RM, Pau N, Tobar BZ, et al. Bartonella Infection in Stray Dogs from Central and Southern Chile (Linares and Puerto Montt). Vector Borne Zoonotic Dis. 2020;20(3):187-192.

Raya AP, Jaffe DA, Chomel BB, et al. Detection of Bartonella species, including Candidatus Bartonella ovis sp. nov, in ruminants from Mexico and lack of evidence of Bartonella DNA in saliva of common vampire bats (Desmodus rotundus) predating on them. Vet Microbiol. 2018;222:69-74.

Moskaluk AE, Stuckey MJ, Jaffe DA, et al. Molecular Detection of Bartonella Species in Blood-Feeding Bat Flies from Mexico. Vector Borne Zoonotic Dis. 2018;18(5):258-265.

Jaffe DA, Chomel BB, Kasten RW, et al. Bartonella henselae in small Indian mongooses (Herpestes auropunctatus) from Grenada, West Indies. Vet Microbiol. 2018;216:119-122.

Undergrad Colby College, ME, Class of 2017
Year MD/PhD 2, JeffMD Phase 2, SKMC 2
Mentor TBD
PhD Program TBD
Research Interests Cancer immunobiology and tumor microenvironment
Anticipated Residency Maybe Pediatric Hem/Onc or Pathology 
Hobbies/Interests Biking, hiking, handicrafts, baking
Favorite Places/Things
to Do in Philadelphia
Riding along Schuylkill river is my jam!
Honors/Awards

Phi Beta Kappa

American Society for Biochemistry and Molecular Biology Travel Award (2017)

Biddle Fund Award for International Research (2015) 

Charles A. Dana Scholar (2014)  

Cancer Prevention & Research Institute of Texas Summer Scholar (2013, 2014)

Publications

Sarkizova, S., Klaeger, S., Le, P.M., Li, L.W., Oliveira, G.,..., Keskin, D.B. (2020). A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Nat Biotechnol. 38, 199-209. 

Keskin, D.B., Anandappa, A.J., Sun, J., Tirosh, I., …Le, P.M., …Reardon, D.A. (2019). Personal neoantigen-targeting vaccination for glioblastoma (GBM) generates intra-tumoral T cell response. Nature 565, 234–239.

Le, P.M., Andreeff, M., Battula, V.L. (2018). Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis. Haematologica. doi:10.3324/haematol.2018.197004.

Le, P.M., Silvestri, V.L., Redstone, S.C., Dunn, J.B., & Millard, J.T. (2018). Cross-linking by epichlorohydrin and diepoxybutane correlates with cytotoxicity and leads to apoptosis in human leukemia (HL-60) cells. Toxicology and Applied Pharmacology 352, 19-27.

Battula, V.L., Le, P.M., Sun, J.C., Nguyen, K., Yuan, B., Zhou, X., … Andreeff, M. (2017). AML-induced osteogenic differentiation in mesenchymal stromal cells supports leukemia growth. JCI Insight, 2 (13).

Undergrad Rutgers University New Brunswick, BA, 2013
Year MD/PhD 2, JeffMD Phase 2, SKMC 2
Mentor TBD
PhD Program TBD
Research Interests I am interested in neuroscience, specifically in the context of traumatic CNS injuries and the mechanisms that underlie neuronal regeneration and repair. I would like to advance our understanding of these processes in order to develop better therapeutic strategies to 1) limit and protect against damage caused by secondary injury cascades and 2) ultimately improve functional recovery for patients.
Anticipated Residency  
Hobbies/Interests I enjoy spending time outdoors, including hiking and camping.
Favorite Places/Things
to Do in Philadelphia
I like to explore new places to eat, Philadelphia has many wonderful restaurants. The Italian Market is also great.
Honors/Awards Undergraduate:
Division of Life Sciences Summer Undergraduate Research Fellowship (2010)
Division of Life Sciences Summer Undergraduate Research Fellowship (2011)
Publications  

Undergrad Columbia University, BA, 2016
Year MD/PhD 2, JeffMD Phase 2, SKMC 2
Mentor TBD
PhD Program TBD
Research Interests Previously, I researched the genetic causes of Autism Spectrum Disorder, pachygyria and meningiomas for two years using whole exome sequencing, gene editing, molecular and biochemical analytical techniques and data prioritization methods to arrive at genetic discoveries. Though I would like to keep working on translational research topics, I would like to branch out from neurological disease models and use my MD/Ph.D. training to learn about other areas.
Anticipated Residency Ophthalmology and luckily, Jefferson offers one of the nation’s top programs
Hobbies/Interests Listening to live music especially R&B and alternative rock, dancing, reading, traveling, following world politics and some sports I enjoy are swimming, tennis, skiing and running.
Favorite Places/Things
to Do in Philadelphia
As someone who recently arrived in Philly, I have limited knowledge of the city but so far, I have enjoyed spending time in Old City where one can visit the historic landmarks, take a stroll through the beautiful parks and admire Philly’s classic row houses. Penn’s Landing and Fishtown are two other popular places which I have yet to explore!
Honors/Awards  
Publications

Mishra-Gorur, K., Li, D., Ma, X., Yarman, Y., Xue, L. and Xu, T., 2019. Spz/Toll-6 signal guides organotropic metastasis in Drosophila. Disease models & mechanisms12(10), p.dmm039727

Kaymakcalan, H., Yarman, Y., Goc, N., Toy, F., Meral, C., Ercan‐Sencicek, A.G. and Gunel, M., 2018. Novel compound heterozygous mutations in GPT2 linked to microcephaly, and intellectual developmental disability with or without spastic paraplegia. American Journal of Medical Genetics Part A, 176(2), pp.421-425.

Duran, D., Messina, R.D., Beslow, L.A., Montejo, J.D., Karimy, J.K., Gavankar Furey, C., Sheridan, A.D., Sze, G., Yarman, Y., DiLuna, M.L. and Kahle, K.T., 2017. Malignant Cerebellar edema subsequent to accidental prescription opioid Intoxication in Children. Frontiers in neurology, 8, p.362.

Undergrad University of Wisconsin-Madison, BS, 2020
Year MD/PhD 1, JeffMD Phase 1, SKMC 1
Mentor TBD
PhD Program TBD
Research Interests I am interested in cancer biology, especially mechanisms related to tumor metastasis and tumor microenvironment.
Anticipated Residency Medical Oncology
Hobbies/Interests MI enjoy classical music (three composers that I like most are Wieniawski, Paganini, and Beethoven). I kind of know how to play piano and Guqin (a Chinese instrument). I also like cooking/baking, watching Korean dramas, and hiking.
Favorite Places/Things
to Do in Philadelphia
TBD
Honors/Awards

Undergraduate:

2019 CPRIT-CURE Summer Undergraduate Program, MDA Cancer Center             

2019-2020 Hilldale Undergraduate Research Fellowship, UW-Madison

2019-2020 Anna L. Rowe Scholarship, CALS, UW-Madison      

2018-2019 Sophomore Research Fellowship, UW-Madison

2018 Summer Undergraduate Research Fellowship, Mayo Clinic

2017-2018 Dorothy Strong Scholarship, CALS, UW-Madison

Publications

Undergraduate:

Tanimura N., Liao R., Wilson GM., Dent MR., Cao M., Burstyn JN., Hematti P., Liu X., Zhang Y., Zheng Y., Keles S., Xu J., Coon JJ., Bresnick EH. 2018. “Gata/Heme Muti-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism.”, Developmental Cell, 46(5):581-594.

Soukup AA., Zheng Y., Mehta C., Wu J., Liu P., Cao M., Hofmann I., Zhou Y., Zhang J., Johnsom KD., Choi K., Keles S., Bresnick EH. 2019. “Single Nucleotide Human Disease Mutation Inactivates a Blood-Regenerative Enhancer.”, Journal of Clinical Investigation,129(3):1180-1192.

Undergrad Yale College, B.S. Molecular Biophysics & Biochemistry, 2018
Year MD/PhD 1, JeffMD Phase 1, SKMC 1
Mentor TBD
PhD Program TBD
Research Interests I am currently interested in translational cancer research using genomic & bioinformatic methods to identify novel molecular targets and develop improved therapies.
Anticipated Residency Currently interested in surgery; looking forward to exploring different specialties during medical school
Hobbies/Interests Electric & acoustic guitar (jazz, blues, funk, and other genres too) and music production, playing squash (the sport, not the vegetable), watching soccer, cooking, traveling.
Favorite Places/Things
to Do in Philadelphia
Looking forward to exploring new restaurants and places to hang out in Philly during my first year!
Honors/Awards Yale Science Scholar Research Fellowship
Publications

Postgraduate:

Johnson KK, Ip K, Rubino S, Leung C, Nawaf CB, Martin TV, Hesse DG. Surgical site infection in robot-assisted radical cystectomy vs. open radical cystectomy. Selected for presentation at The New England Section of The American Urological Association, Annual Meeting, Burlington, Vermont. September 2020.

Ip K, Thomas MA, Khunte A, Behar KL, de Graaf RA, De Feyter HM. Mapping of exogenous choline uptake in brain tumors in vivo using Deuterium Metabolic Imaging (DMI). Selected for oral presentation, International Society for Magnetic Resonance in Medicine, Virtual Conference. August 2020.

Undergraduate:

Saeyeldin A, Zafar MA, Velasquez CA, Ip K, Gryaznov A, Brownstein AJ, Li Y, Rizzo JA, Erben Y, Ziganshin BA, Elefteriades JA. Natural history of aortic root aneurysms in Marfan syndrome. Ann Cardiothorac Surg 6, 625–632 (2017).

Fan C, Ip K, Söll D. Expanding the Genetic Code of Escherichia coli with Phosphotyrosine. FEBS Lett. 590(17), 3040-3047 (2016).

De Feyter HM, Behar KL, Rao JU, Madden-Hennessy K, Ip K, Hyder F, Drewes LR, Geschwind J-F, de Graaf RA, Rothman DL. A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth. Neuro Oncol. 18(8), 1079-1087 (2016).

Miller C, Bröcker MJ, Prat L, Ip K, Chirathivat N, Feiock A, Veszprémi M, & Söll D. A synthetic tRNA for EF-Tu mediated selenocysteine incorporation in vivo and in vitro. FEBS Lett. 589(17), 2194-2199 (2015).

Undergrad Penn State, Pre-Medical-Medical (PMM), 2020
Year MD/PhD 1, JeffMD Phase 1, SKMC 1
Mentor TBD
PhD Program TBD
Research Interests My previous research examined how copy number variants (CNVs), which are genomic deletions and duplications typically spanning multiple genes, affect gene dosage in patients and contribute to the pathogenesis of neurodevelopmental disorders such as autism, schizophrenia, and intellectual disability. I am interested in further pursuing neuroscience research, especially in the context of translational work, but I’m certainly open to exploring other exciting disciplines like immunology and cancer biology.
Anticipated Residency TBD
Hobbies/Interests I'm really passionate about soccer, and you'll find me either playing it or watching it whenever I can.  My other hobbies include reading about US history and staying informed about/discussing current events. I also like to think I have a green thumb and love growing everything from succulents to orchids to even carnivorous plants!
Favorite Places/Things
to Do in Philadelphia
I have yet to explore the city, but I can't wait to get started!
Honors/Awards

Ruth E. Duffy Pre-Medicine Endowment (2019)

Eberly College of Science Ovadia Scholarship (2019)

President Sparks Award (2019)

Rodney A. Erickson Discovery Grant (2019)

Evan Pugh Senior Scholar Award (2020)

Publications

Yusuff T, Jensen M, Yennawar S, Pizzo L, Karthikeyan S, Gould DJ, Sarker A, Gedvilaite E, Matsui Y, Iyer J, Lai ZC, Girirajan S. (2020) Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development. PLOS Genetics 16(6): e1008792. https://doi.org/10.1371/journal.pgen.1008792

Pizzo L, Lasser M, Yusuff T, Jensen M, Ingraham P, Huber E, Singh MD, Monahan C, Iyer J, Desai I, Karthikeyan S, Weiner A, Krishnan A, Rolls M, Lowery LA, Girirajan S. Functional assessment of the “two-hit” model for neurodevelopmental defects in Drosophila and X. laevis models of 16p12.1 deletion. (Under Review, Genome Research)

Undergrad Cornell University, BA, 2017
Year MD/PhD 1, JeffMD Phase 1, SKMC 1
Mentor TBD
PhD Program TBD
Research Interests I have previously studied chemoresistance in ovarian cancers, and I would like to continue in women’s health research during my MD/PhD. I am interested in breast, ovarian, and cervical cancers, as well as infertility.
Anticipated Residency Obstetrics and Gynecology
Hobbies/Interests I love baking, reading, and writing poetry. I also enjoy trying new restaurants and seeing live music with friends!
Favorite Places/Things
to Do in Philadelphia
Philly has fantastic museums! Some of my favorites are the Barnes Foundation, which has one of the world’s largest impressionist collections, and the Mutter Museum, which documents medical history through specimens and medical tools. I love the collection of over 2,000 swallowed objects removed by one surgeon!
Honors/Awards Undergraduate: Society of American Naturalists Ruth Patrick Student Poster Award
Publications Fukumoto, T., Magno, E., & Zhang, R. (2018). SWI/SNF complexes in ovarian cancer: mechanistic insights and therapeutic implications. Molecular Cancer Research, 16 (12); 1-7. DOI: 10.1158/1541- 7786.MCR-18-0368