Faculty & Staff
Scott A. Waldman MD, PhD, FCP
Dr. Scott Waldman, the MD/PhD Program Director, is Professor and Chair of the Department of Pharmacology and Experimental Therapeutics. His research focuses on GCC, demonstrating the importance of this receptor as a novel tumor suppressor central to the induction of colorectal cancer, and the translation of those observations to patient care. Indeed, he is the PI of NCI multi-institutional clinical trials examining the utility of GCC as a molecular marker for managing patients with, and as a target for the prevention of, colorectal cancer. Projects in his laboratory examine the translation of GCC biology into approaches to image colorectal tumors, prevent neoplastic transformation in intestine, and paradigms for vaccine development for patients with colorectal cancer. His research combines both basic and clinical investigation and serves as an exemplar of translational research. Dr. Waldman’s office is 368J Jefferson Alumni Hall (JAH)
Manuel Covarrubias, MD, PhD
Dr. Manuel Covarrubias, the MD/PhD Program Co-director, is Professor in the Department of Neuroscience and member of the Vickie and Jack Farber Institute for Neuroscience. Dr. Covarrubias’ major research interests concern two areas: 1) molecular mechanisms underlying pain sensitization induced by spinal cord injury; and 2) molecular mechanisms of general anesthesia. In the first area, his laboratory has identified a specific potassium channel as a major regulator of excitability in the peripheral pain pathway. This finding is the basis of efforts to investigate novel therapeutic targets to treat neuropathic pain. In the second area, his team has discovered sites of general anesthetic action in voltage-gated ion channels that govern the brain’s electrical activity. Further work in this area will promote the development of more effective and less toxic general anesthetics. Dr. Covarrubias collaborates with researchers from major universities in Philadelphia as well as universities and companies overseas. His research has been supported by the National Institutes of Health for more than 20 years. Dr. Covarrubias' office is 231 Bluemle Life Sciences Bldg. (BLSB).
Danielle Park is the MD/PhD Administrative Director. Her office is 1020 Locust Street, M-46 Jefferson Alumni Hall (JAH). Danielle can be reached by phone at (215) 503-0164 and by email at Danielle.Park@jefferson.edu
Administrative oversight for the Program is provided by the MD/PhD Steering Committee, chaired by Dr. Gerald Grunwald, Dean of the Jefferson College of Life Sciences and Professor of Pathology, Anatomy & Cell Biology, and is composed of faculty involved in the scientific and/or clinical training of MD/PhD students. There are also two student representatives to this committee, elected officers of the Jefferson Physician Scientist Association.
Danielle.Park@jefferson.edu | 215-503-0164
Clicking on the faculty member's name will take you their Profile page for more information regarding their area of research.
Lorraine Iacovitti, PhD
Stem cells to study and treat Parkinson's disease; Neuroprotective agents to treat Parkinson's Disease; Stem cells to treat stroke; Sites of adult stem cells in brain
Renato V. Iozzo, MD
Professor, Pathology, Anatomy & Cell Biology
Proteoglycan control of cancer growth and angiogenesis; Tumor microenvironment and regulation of receptor tyrosine kinases by matrix molecules
Felix Kim, PhD
Associate Professor, Cancer Biology
Basic and translational research focused on investigating the role of Sigma1 (also known as sigma-1 receptor) in tumor metabolism, modulation of the tumor microenvironment, and discovering and developing novel Sigma1 targeted therapeutic agents and approaches to treating advanced prostate cancer.
Le Ma, PhD
Associate Professor, Neuroscience
Neural networks; molecular pathways involved in branching; cell biological regulation of branching; contribution of branching to circuit function and repair
A. Sue Menko, PhD
Professor, Pathology, Anatomy & Cell Biology
Signaling mediating acquisition of the differentiated cell phenotype; Cell adhesion and the cytoskeleton in regulating tissue morphogenesis, regeneration, and fibrosis
Timothy Mosca, PhD
Assistant Professor, Neuroscience
Molecular mechanisms and the organizational logic of how synapses are constructed; deciphering the genes involved in synapse formation and composition
Isidore Rigoutsos, PhD
Professor, Pathology, Anatomy & Cell Biology, Center for Computational Medicine
Computational medicine; microRNAs; tRNAs; piRNAs; post-transcriptional regulatory processes; diagnostics; therapeutics; genomics; big data; pattern/motif discovery; high performance computing; microbial genomics; metagenomics
Abdolmohamad Rostami, MD, PhD
Professor and Chair, Neurology
Helper T cell subsets and their cytokines in the pathogenesis of autoimmune encephalomyelitis (EAE) and multiple sclerosis; Effect of Bowman-Birk serine protease inhibitor on course of EAE; Mechanisms of intravenous tolerance in EAE; Effects of interleukin-27 (IL-27) on human auto-aggressive T cells.
Irving M. Shapiro, PhD
Professor, Orthopaedic Surgery
Chondrocyte apoptosis and autophagy; Stem cell function in the intervertebral disc; Development of methods to attach bioactive substances to metals utilized for orthopaedic implants
Shey-Shing Sheu, PhD
Knowledge to assist the development and discovery of therapeutic strategies targeting mitochondrial dysfunction that causes disease projection such as cardiac arrythmias and heart failure
Daniel P. Silver, MD, PhD
Associate Professor, Medical Oncology
Breast Cancer; Triple Negative Breast Cancer; Inflammatory Cancer; Hereditary Breast and Ovarian Cancer Syndrome; Atypical Hyperplasia (ADH, ALH); Lobular Carcinoma in Situ (LCIS); DNA Repair Defects
Christopher Snyder, PhD
Associate Professor, Microbiology & Immunology
Viral immunology: maintenance of adaptive immunity during chronic infections; T cell responses elicited by cytomegalovirus infection; activation of T cell effector functions by innate signals
Ross Summer, MD
Professor, Medicine, Pulmonary & Critical Care
Dr Summer's laboratory focuses on lung metabolism and understanding how local and systemic metabolic derangements contribute to the onset and progression of lung diseases.
Scott A. Waldman, MD, PhD
Professor and Chair, Pharmacology & Experimental Therapeutics
Tumor suppressors and their signaling pathways in GI malignancies; Targeted diagnostics and therapeutics in cancer