Genetics, Genomics & Cancer Biology

College

  • Center City Campus
  • College of Life Sciences

Degree Earned

  • Doctor of Philosophy
  • Doctorate

Program Length

4-5 years

Program Type

  • On Campus

Prerequisities

BS/MS | See more

Contact Information

Program

Name: Lucia Languino, PhD
Position: Program Director

233 South 10th Street
Bluemle Life Sciences Building, Suite 506
Philadelphia, PA 19107

Telephone: 215-503-3442

Admissions

Telephone: 215-951-2800

Connect with Us

       

Curriculum

The Program is focused on research training, which begins in the first year as rotations in different laboratories, and continues as the student begins potential thesis projects in a chosen mentor's laboratory. The PhD thesis research involves critical thinking and executing ideas in the laboratory through the use of sound scientific methods. Students are guided by their mentors and a selected thesis research committee, which meets on a routine basis throughout the training experience.

In the first year, students complete Foundations in Biomedical Sciences, a course that provides a foundation in Biochemistry, Cell Biology, Genetics and Molecular Biology. They then proceed to basic courses in Genetics, followed by more advanced specialized training. Course work during the first year is enhanced by three laboratory rotations, in which students learn advanced laboratory techniques and the principles of sound experimental methods.

At the end of the first year, the student selects a faculty supervisor for his or her thesis research. During the second year, the student takes specialized courses that focus on different aspects of the genetics of cancer and human diseases, including the molecular genetics of growth control, oncogene activation, tumor suppression, regulation of gene expression, receptor-ligand interactions and signal transduction. Additional credit hours of elective courses are available, and are generally geared to meet the individual needs of students as they move into the specific areas of their thesis research. 

Throughout their experience, students take part in weekly journal clubs and attend regularly scheduled faculty and student seminars in molecular genetics and cancer biology as well as seminars given by invited speakers. Students are also trained and encouraged to present their work at both in-house and outside scientific meetings.

Course requirements are completed by the end of the second year and students spend an average of another two to three years to complete their individual thesis projects.

Typical areas of research include: functional genomics and epigenetics, analysis of the human genome, genetics of cancer susceptibility, genetics of the immune system, molecular genetics of animal models of human disease, molecular genetics of hematopoietic neoplasias and solid tumors, mechanisms of altered growth regulation by oncogenes and tumor suppressor genes, transcriptional regulation, chromatin organization and the control of gene expression, translational research, molecular therapeutics and personalized medicine.

Note: Credits for the 910, 920 and 930 Research courses and Electives are variable. Assign credits to Research and/or Electives to equal the target number of credits for each semester.

Fall Semester (20 Credits)
Course Title Credits
GC 550 Foundations of Biomedical Sciences      10
GC 760 PhD Laboratory Rotations       3
GE 710 Current Literature       1
GE 715 Seminar       1
GE 910 Research  Variable
Winter Semester (10 Credits)
Course Title Credits
GE 940 Research  Variable
Spring Semesters (30 Credits)
Course Title Credits
BI 525 Biochemistry-Genetics Information Transfer       3
GC 640 Research Ethics       1
GC 770/780 PhD Laboratory Rotation       3
NS 740 Applied Statistics       2
GE 612 Genetics of Model Organisms       2
GE 637 Human Genetics       3
GE 720 Current Literature       1
GE 725 Seminar       1
GE 920 Research  Variable
Summer Semester (10 Credits)
Course Title Credits
GE 930 Research Variable

Fall Semester (20 Credits)
Course Title Credits
Elective(s)  Variable
GE 636 Regulation of Cell Cycle and Apoptosis       3
GE 710 Current Literature       1
GE 715 Seminar       1
GE 910 Research Variable
Winter Semester (10 Credits)
Course Title Credits
GE 940 Research  Variable
Spring Semesters (30 Credits)
Course Title Credits
GC 675 Cancer Immunology       2
GC 645 Genomics & Bioinformatics       3
IMP 505A Fundamentals of Immunology       2
GE 652 Molecular Basis of Cancer       2
GE 720 Current Literature       1
GE 725 Seminar       1
GE 920 Research  Variable
Summer Semester (10 Credits)
Course Title Credits
GE 930 Research Variable

Fall Semester (20 Credits)
Course Title Credits

GE 710 Current Literature

1

GE 715 Seminar

1

GE 910 Research

Variable

Preliminary Examination

 

Winter Semester (10 Credits)
Course Title Credits
GE 940 Research  Variable
Spring Semesters (30 Credits)
Course Title Credits
GE 720 Current Literature       1
GE 725 Seminar       1
GE 920 Research  Variable
Summer Semester
Course Title Credits
GE 930 Research Variable