Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Romero, Freddy Jose

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Freddy Jose Romero, PhD

Freddy Jose Romero, PhD

Contact Dr. Romero

1020 Locust Street
Jefferson Alumni Hall, Room 381
Philadelphia, PA 19107

(215) 503-0444
(215) 503-5731 fax

PhD Biochemistry, Venezuelan Institute for Scientific Research (IVIC), Caracas, Venezuela 2006
BS Biology, University of Zulia, Maracaibo, Venezuela, 1996

Harvard Medical School

University Appointment
Assistant Professor
Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine

Professional Societies
American Thoracic Society

Research and Clinical Interests
The overall goal of my research is to elucidate the pathogenic mechanisms leading to the development of pulmonary fibrosis. Specifically, one focus of my work is to understand how defects in lysosome-related trafficking protein contribute to the pathogenesis of pulmonary fibrosis. Various genetic mutations have been linked to the development of pulmonary fibrosis including mutations in the lysosome-related trafficking protein AP3b1. These mutations are observed in patients with Hemansky-Pudlak syndrome (HPS), a rare condition characterized by cutaneous albinism, platelet granule defects and pulmonary fibrosis. Although the mechanisms by which AP3b1 mutations cause pulmonary fibrosis are not understood the localization of this protein to alveolar epithelial type II (AEII) cells has as least helped to focus attention on the lung epithelium. We demonstrate that AP3b1 deficient cells are ill-equipped to respond to injury because they are unable to activate survival signaling pathways and display enhanced susceptibility to apoptotic cell death. In these investigations, I hope to shed light on how specialized endosomal sorting processes to and from lysosome-related organelle helps AEII cells adapt to environmental stress and injury.



Publications for this author are currently unavailable.