Thomas Jefferson University
Sidney Kimmel Medical College
Department of Medicine

Romero, Freddy Jose

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Freddy Jose Romero, PhD

Freddy Jose Romero, PhD

Contact Dr. Romero

1020 Locust Street
Jefferson Alumni Hall, Room 381
Philadelphia, PA 19107

(215) 503-0444
(215) 503-5731 fax

PhD Biochemistry, Venezuelan Institute for Scientific Research (IVIC), Caracas, Venezuela 2006
BS Biology, University of Zulia, Maracaibo, Venezuela, 1996

Harvard Medical School

University Appointment
Assistant Professor
Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine

Professional Societies
American Thoracic Society

Research and Clinical Interests
The overall goal of my research is to elucidate the pathogenic mechanisms leading to the development of pulmonary fibrosis. Specifically, one focus of my work is to understand how defects in lysosome-related trafficking protein contribute to the pathogenesis of pulmonary fibrosis. Various genetic mutations have been linked to the development of pulmonary fibrosis including mutations in the lysosome-related trafficking protein AP3b1. These mutations are observed in patients with Hemansky-Pudlak syndrome (HPS), a rare condition characterized by cutaneous albinism, platelet granule defects and pulmonary fibrosis. Although the mechanisms by which AP3b1 mutations cause pulmonary fibrosis are not understood the localization of this protein to alveolar epithelial type II (AEII) cells has as least helped to focus attention on the lung epithelium. We demonstrate that AP3b1 deficient cells are ill-equipped to respond to injury because they are unable to activate survival signaling pathways and display enhanced susceptibility to apoptotic cell death. In these investigations, I hope to shed light on how specialized endosomal sorting processes to and from lysosome-related organelle helps AEII cells adapt to environmental stress and injury.



Most Recent Peer-Reviewed Publications

  1. A pneumocyte-macrophage paracrine lipid axis drives the lung toward fibrosis
  2. Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury
  3. Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension
  4. Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation, and impairs alveolar macrophage functions
  5. Plasma adiponectin, clinical factors, and patient outcomes during the acute respiratory distress syndrome
  6. Extracellular ATP mediates the late phase of neutrophil recruitment to the lung in murine models of acute lung injury
  7. The hepatocyte growth factor reduces vascular inflammatory mediators and hypertension in spontaneously hypertensive rats
  8. Scleroderma-related lung disease: Are Adipokines Involved Pathogenically?
  9. Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension
  10. Overexpression of HGF transgene attenuates renal inflammatory mediators, Na+-ATPase activity and hypertension in spontaneously hypertensive rats
  11. Isolation and cloning of the K+-independent, ouabain-insensitive Na+-ATPase
  12. Cocaine use, arterial hypertension and chronic kidney disease
  13. Effect of uric acid on hypertension progression in spontaneously hypertensive rats
  14. Effect of uric acid on nephrotoxicity induced by mercuric chloride in rats
  15. Effect of uric acid on gentamicin-induced nephrotoxicity in rats - Role of matrix metalloproteinases 2 and 9
  16. Solubilization and partial characterization of ouabain-insensitive Na +-ATPase from basolateral plasma membranes of the intestinal epithelial cells
  17. Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction
  18. Pathophysiological Mechanisms of Salt-Dependent Hypertension
  19. Melatonin prevents oxidative stress resulting from iron and erythropoietin administration
  20. Mycophenolate mofetil treatment reduces cholesterol-induced atherosclerosis in the rabbit
  21. Melatonin attenuates acute renal failure and oxidative stress induced by mercuric chloride in rats
  22. Oxidative stress in renal transplantation with uneventful postoperative course
  23. Mycophenolate mofetil prevents the progressive renal failure induced by 5/6 renal ablation in rats