Evidence-Based Quality Research

We design and perform prospective studies or include the quality assurance (QA) as a part of larger clinical trials to evaluate QA programs. An example of this research was a study conducted to improve contour consistency before trial activation. Another example was the continuous adaption of image-guided radiation therapy credentialing procedure from QA data collected and analyzed.

Secondary Analysis of Data Collected Through Clinical Trials

Large amount of data are collected through clinical trial processes, including multimodality imaging/treatment planning/verification digital data, associated pre- and post-treatment (quantitative) imaging data, and associated metadata, including outcomes. These data represent a potentially valuable resource for the research into quality assessment and other scientific investigations. It is recognized that the data will be the property of the primary group performing the study and that they must be engaged with respect to additional analyses.

Clinical Trial Quality Assurance Techniques Research & Tools Development

Researches are conducted for effective QA techniques and methodologies, bringing expertise from NCI clinical trial network (NCTN) investigators and from other scientific disciplines. As part of this research direction, scientists and collaborators will develop and validate knowledge-based models for IMRT dose prediction based on “best available” knowledge and past experience, taking into account patient’s unique anatomy for IMRT planning quality assurance.

The QA workflow processes will also be evaluated constantly for efficiency and cost-effectiveness.

Design Lab

The Department of Radiation Oncology has several on-going projects in 3D-printing with the Jefferson Health Design Lab. The Jefferson Health Design lab is an innovative group that works with clinicians and designers to create impactful solutions to tough healthcare challenges. There are materials research opportunities in MR-guided radiation therapy and QA, brachytherapy, and patient-specific devices. Learn more about the Jefferson Health Design Lab.