1020 Locust Street
Philadelphia, PA 19107
Laboratory: Adam Snook, PhD
Project: Colorectal cancer is the second leading cause of cancer-related death in the United States. My project focuses on understanding how chimeric antigen receptor (CAR) T cell immunotherapy can be implemented to treat metastatic colorectal cancer using patient-derived models.
Laboratory: Claudio Giraudo, PhD
Project: The synaptic membrane is highly dynamic and upon immune synapse polarization requires rapid replenishment as well as regulation of necessary lipids for continuous signaling. I am interested in characterizing the role of Extended-Synaptotagmins in human cytotoxic T lymphocytes during the immunological synapse formation.
Laboratory: Fabienne Paumet, PhD
Project: The eukaryotic cytoskeleton is an incredibly dynamic system that is vital to the proper function of the cell, and has subsequently become a common target for many pathogenic bacteria. Chlamydia trachomatis, the most frequently reported sexually transmitted disease, manipulates the host cytoskeleton to enhance its survival and pathogenicity. I am studying the molecular machinery that Chlamydia utilizes to reorganize the cytoskeleton in an attempt to better understand its complex survival strategies.
Laboratory: Abdolmohamad Rostami, MD, PhD
Project: Myeloid cells are the most prevalent cell type found in active lesions in the brains of multiple sclerosis patients. My research interests are in understanding how myeloid cells mediate pathology in multiple sclerosis and developing methods for targeting them in a clinical setting.
Laboratory: Fabienne Paumet, PhD
Project: Chlamydia trachomatis is an obligate intracellular pathogen responsible for significant disease burden as a sexually transmitted infection and as the leading cause of infectious blindness. This bacterial pathogen survives inside its host cell, causing dramatic cellular rearrangements to establish an inclusion in which to grow, replicate, and evade host immune detection. My project focuses on a chlamydial fusion protein involved in inclusion dynamics and the functional consequences of inclusion fusion on pathogenesis.
Laboratory: Gudrun Debes, PhD
Project: IL-10 producing B cells are important in regulating the immune response in autoimmune diseases and cancers, but the signals that control their development are not well understood. I am studying the mechanisms through which IL-10 positive B cells are generated and maintained.
Laboratory: David Abraham, PhD
Project: Onchocerciasis is a debilitating neglected tropical disease caused by the filarial nematode Onchocerca volvulus. Over the past several years, the Abraham Lab and various collaborators have developed a bivalent, recombinant antigen vaccine that has been shown to induce a protective immune response in various animal models. My project aims to understand the mechanism in which the Onchocerca Vaccine induces protective immunity and how this knowledge can be applied to understanding the broader interaction between the immune system and parasitic nematodes.
Laboratory: Christopher Snyder, PhD
Project: Cytomegalovirus (CMV) establishes lifelong infection through viral latency and persistence in mucosal tissues, but the mechanisms are not well understood. I am investigating the role of specialized pro-resolving lipid mediators, which modulate tissue homeostasis, on CMV persistence in mucosal tissue, particularly focusing on the nasal mucosa.
John Flickinger (MD/PhD)
Thesis Title: “Guanylyl Cyclase C Vaccines for Secondary Prevention of Metastatic Colorectal Cancer”
Advisor: Adam Snook, PhD
Current Position: MD/PhD 8, JeffMD Phase 3, SKMC 4
Thesis Title: “Protein trafficking and unchaperoned translation during a viral infection determine antigen processing outcomes for MHC class I direct presentation”
Advisor: Laurence Eisenlohr, PhD
Current Position: TBD
Thesis Title: “Development and characterization of a broadly protective lyssavirus vaccine”
Advisor: Matthias Schnell, PhD
Current Position: Draper Laboratory, Senior Biologist, Synthetic Biology
Thesis Title: “Defects of the Innate Immune System Contribute to Age-related Susceptibility to Mousepox”
Advisor: Luis Sigal, PhD
Current Position: Investigator, GlaxoSmithKline, Innate Immune Research Unity