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Immunology & Microbial Pathogenesis
Contact
Name:
Fabienne Paumet, PhD
Position:
- Co-Director, Immunology & Microbial Pathogenesis PhD Program
- Associate Professor
Position:
Department of Microbiology & Immunology
233 S. Tenth Street
Bluemle Life Sciences Building, Room 750
Philadelphia, PA 19107
Contact Number(s):
Contact
Name:
Christopher Snyder, PhD
Position:
- Co-Director, Immunology & Microbial Pathogenesis PhD Program
- Associate Professor
Position:
Department of Microbiology & Immunology
233 S. 10th Street, 730 BLSB
Philadelphia, PA 19107
Contact Number(s):
Contact
Name:
Danielle Park
Department:
Jefferson College of Life Sciences
1020 Locust Street
M-46 JAH
Philadelphia, PA 19107
Email:
Danielle.Park@jefferson.edu
Current Students
Juliana Benitez
Juliana.Benitez@students.jefferson.edu
Matriculation Term: Fall 2022
Thesis Advisor: Luis Sigal, PhD
Project: I am researching the mechanisms and cell populations responsible for antigen presentation to CD8 T-cells after mRNA vaccination.
Lauren Berish
Lauren.Berish@students.jefferson.edu
Matriculation Term: Fall 2024
Thesis Advisor: TBA
Project: TBA
Emilee Brockner
Emilee.Brockner@students.jefferson.edu
Matriculation Term: Fall 2023
Thesis Advisor: Fabienne Paumet, PhD
Project: Chlamydia trachomatis is an obligate intracellular pathogen responsible for significant disease burden as the most common sexually transmitted infection and the leading cause of infectious blindness. My project focuses on elucidating how IncA-mediated homotypic inclusion fusion during Chlamydia infection promotes pathogenicity and alters the host immune response.
Tien Bui
Tien.Bui@students.jefferson.edu
Matriculation Term: Summer 2022
Thesis Advisor: Zia Rahman,MD, PhD
Project: My project focuses on understanding the regulatory mechanisms of an E3 ubiquitin ligase Peli1 in systemic autoimmunity development using various SLE mouse models. Specifically, I will be investigating its potential role in regulating autoreactive B cell development in the germinal center or extrafollicular plasma cell differentiation pathway.
Miao Cao (MD/PhD)
Miao.Cao@students.jefferson.edu
Matriculation Term: Summer 2022
Thesis Advisor: Adam Snook, PhD
Project: TBA
Jihae Choi
Jihae.Choi@students.jefferson.edu
Matriculation Term: Summer 2022
Thesis Advisor: Sangwon Kim, PhD
Project: TBA
Vincent Cooper
Vincent.Cooper@students.jefferson.edu
Matriculation Term: Fall 2022
Thesis Advisor: Botond Igyártó, PhD
Project: Mechanistic studies of contact dependent mRNA transfer between dendritic cells and their neighbors.
Sophia Crocker
Sophia.Crocker@students.jefferson.edu
Matriculation Term: Fall 2024
Thesis Advisor: TBA
Project: TBA
Alec Delgado
Alec.Delgado@students.jefferson.edu
Matriculation Term: Fall 2024
Thesis Advisor: TBA
Project: TBA
Jacqueline Flynn
Jaqueline.Flynn@students.jefferson.edu
Matriculation Term: Summer 2022
Thesis Advisor: Claudia Capparelli, PhD
Project: My project focuses on characterizing extracellular matrix remodeling in drug-tolerant, phenotypically mesenchymal cell states in melanoma as a mechanism of adaptive resistance to therapies and targeting resistant cell populations to boost CD8+ T cell infiltration to the tumor immune microenvironment.
Soprina Guarneri
Soprina.Guarneri@students.jefferson.edu
Matriculation Term: Fall 2023
Thesis Advisor: Anjali Mishra, PhD
Project: TBA
Zachary Hutchins
Zachary.Hutchins@students.jefferson.edu
Matriculation Term: Summer 2021
Thesis Advisor: Anjali Mishra, PhD
Project: TBA
Samita Kafle
Samita.Kafle@students.jefferson.edu
Matriculation Term: Fall 2020
Thesis Advisor: Luis Sigal, PhD
Project: I study the role of innate immunity, particularly Type I and III Interferons, in controlling Coxsackievirus B3 (CVB3) pathogenesis, a non-polio enterovirus that is the leading cause of viral myocarditis in children, by using specific Interferon-Knockout mouse models.
Jessica McCord
Jessica.McCord@students.jefferson.edu
Matriculation Term: Fall 2021
Thesis Advisor: Christopher Snyder, PhD
Project: TBA
Jesse Miller
Jesse.Miller@students.jefferson.edu
Matriculation Term: Fall 2023
Thesis Advisor: Matthias Schnell, PhD (Mentor)/ Drishya Kurup, PhD (Co-mentor)
Project: TBA
Aaren Milne
Aaren.Milne@students.jefferson.edu
Matriculation Term: Fall 2023
Thesis Advisor: Fabienne Paumet, PhD
Project: The Chlamydial Protein InaC Coordinates the Reorganization of Actin and Microtubules via Two Functional Domains
Jacob Myers (MD/PhD)
Jacob.Myers@students.jefferson.edu
Matriculation Term: Summer 2023
Thesis Advisor: Matthias Schnell, PhD
Project: TBA
Daniel Netting
Daniel.Netting@students.jefferson.edu
Matriculation Term: Fall 2021
Thesis Advisor: Adriana Mantegazza, PhD
Project: Professional phagocytes, such as dendritic cells and macrophages, must be able to sense and transport nutrients in the phagosome in order to better recognize and respond to phagosomal cargo. My research is centered around the role of nucleoside transport in the dendritic cell lysosome and phagosome, mediated by solute carrier 29A3, and how nucleoside transport contributes to the induction and regulation of immune responses.
Gerald O'Connor
Gerald.O'Connor@students.jefferson.edu
Matriculation Term: Fall 2021
Thesis Advisor: Sangwon Kim, PhD
Project: C10ORF99 is a protein that is highly expressed in the colon at steady state and functions as the homing ligand for GPR15-expressing cells. In addition to its function as GPR15’s ligand, there is also evidence from skin studies that C10ORF99 has GPR15-independent functions. However, in vivo studies regarding its GPR15-independent roles in the colon, specifically as they relate to inflammatory bowel disease and colorectal cancer, have been lacking. My project addresses this knowledge gap around C10ORF99’s GPR15-independent functions as they relate to colon homeostasis.
Mary O'Mara
Mary.O'Mara@students.jefferson.edu
Matriculation Term: Summer 2022
Thesis Advisor: Holly Ramage, PhD
Project: My project explores the molecular interactions between viral and host proteins during flavivirus infection to identify novel mechanisms of host antiviral immunity and viral immune evasion.
Sergey Panteleev
Sergey.Panteleev@students.jefferson.edu
Matriculation Term: Fall 2021
Thesis Advisor: Yuri Sykulev, PhD
Project: TBA
Megan Serydarian
Megan.Serydarian@students.jefferson.edu
Matriculation Term: Fall 2024
Thesis Advisor: TBA
Project: TBA
Carly Smith
Carly.Smith2@students.jefferson.edu
Matriculation Term: Fall 2021
Thesis Advisor: Theresa Freeman, PhD
Project: I am investigating the use of cold atmospheric plasma for treatment of orthopedic infection by exploring its role in reducing bacterial pathogenesis and enhancing the innate immune response
Lauren Springer
Lauren.Springer@students.jefferson.edu
Matriculation Term: Summer 2018
Thesis Advisor: Christopher Snyder, PhD
Project: Cytomegalovirus (CMV) establishes lifelong infection through viral latency and persistence in mucosal tissues, but the mechanisms are not well understood. I am investigating the role of specialized pro-resolving lipid mediators, which modulate tissue homeostasis, on CMV persistence in mucosal tissue, particularly focusing on the nasal mucosa.
Zachary Walter
Zachary.Walter@students.jefferson.edu
Matriculation Term: Fall 2020
Thesis Advisor: Holly Ramage, PhD
Project: TBA
Recent Graduates
Saul Kushinsky (MD/PhD)
Matriculation Term: Summer 2016
Thesis Title: "The Unique Contributions of DNA Replication Fork Remodeling Proteins in Hematopoiesis and DNA Replication Stress"
Advisor: Christine Eischen, PhD
Current Position: MD/PhD 9, JeffMD Phase 2, SKMC 3
Trevor Baybutt
Matriculation Term: Fall 2016
Thesis Title: "CD8ɑ Structural Domains Enhance GUCY2C CAR-T Cell Efficacy"
Advisor: Adam Snook, PhD
Christine Linton
Matriculation Term: Fall 2020
Thesis Title: "Characterization of a Bacterial Membrane Fusion Machine"
Advisor: Fabienne Paumet, PhD
Shantel Rios
Matriculation Term: Fall 2019
Thesis Title: "The Development of Rabies Virus-Vectored Lyme Disease Vaccines"
Advisor: Matthias Schnell, PhD
Nathan Ryan
Matriculation Term: Fall 2020
Thesis Title: "Development of a vaccine against the parasitic nematode Onchocerca volvulus"
Advisor: David Abraham, PhD
Nathalia Benavides
Matriculation Term: Fall 2018
Thesis Title: "Investigating Mechanisms of T Cell Activation Through Lipid Modulation and Pediatric Immune Dysregulation Disorders"
Advisor: Claudio Giraudo, PhD
Adam Haines
Matriculation Term: Fall 2018
Thesis Title: "Chlamydia trachomatis coordinates distinct cytoskeletal elements to regulate its virulence"
Advisor: Fabienne Paumet, PhD
Christopher Herbst
Matriculation Term: Fall 2019
Thesis Title: "A Unique Mechanism of Antigen Uptake by Dendritic Cells and its Effect on Conditional Gene Deletion"
Advisor: Botond Igyártó, PhD
Shannon Mcgettigan
Matriculation Term: Fall 2016
Thesis Title: "The homeostasis of IgM secreting cells in skin and lymphoid tissues and the role of secreted IgM in modulating IL-10+ B cells"
Advisor: Gudrun Debes, DVM
John Flickinger (MD/PhD)
Matriculation Term: Summer 2015
Thesis Title: "Guanylyl Cyclase C Vaccines for Secondary Prevention of Metastatic Colorectal Cancer"
Advisor: Adam Snook, PhD
Current Position: University of Pittsburgh Medical Center (UPMC), Research Residency
Daniel Hwang
Matriculation Term: Fall 2017
Thesis Title: "CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation"
Advisor: Abdolmohamad Rostami, MD, PhD
Brian Montoya
Matriculation Term: Fall 2017
Thesis Title: "Studies on the role of necroptosis proteins RIPK3 and MLKL in resistance to viral infection and on the role of CD8 T-cells induced by mRNA-LNP vaccines in protection from SARS-CoV-2 in mice"
Advisor: Luis Sigal, DVM, PhD
Gabrielle (Gabby) Scher
Matriculation Term: Fall 2017
Thesis Title: "Development of Rhabdoviral-based Crimean-Congo Hemorrhagic Fever Virus Vaccines"
Advisor: Matthias Schnell, PhD
Catherine Yankowski
Matriculation Term: Fall 2017
Thesis Title: "Formulation of the Rabies Virus Vaccine Vector Against Emerging Viruses"
Advisor: Matthias Schnell, PhD
Gabriela Cosma
Matriculation Term: Fall 2014
Thesis Title: "Protein trafficking and unchaperoned translation during a viral infection determine antigen processing outcomes for MHC class I direct presentation"
Advisor: Laurence Eisenlohr, PhD