Past Projects
Observational Clinical Study of the Intravenous Blood Glucose System in Hospitalized Adult Elective or Non-Emergent Surgery and Medical/Surgical Intensive Care Unit Patients
| Sponsor |
Edwards Lifesciences and DexCom Corporation |
| Investigators |
Jeffrey Joseph, DO, Brian Hipszer, PhD., Zvi Grunwald, MD, Charles Yeo, MD, Boris Mraovic MD, David Gratch, DO |
| Description |
Human trial to evaluate intravenous blood glucose monitoring system in hospitalized patients in OR and ICU. |
Research, Development, In-Vitro Testing, & In-Vivo Testing of Automated Blood Sampling System
| Sponsor |
Hospira Inc. |
| Investigators |
Jeffrey Joseph, DO, Brian Hipszer, PhD, Ji-Bin Liu, MD |
| Description |
Laboratory and animal studies to develop, test, and optimize automated blood sampling system attached to an intravenous catheter for glucose monitoring in the hospital. |
An Unblinded, Non-Randomized Study to Evaluate the Accuracy of the Sentris-100 in Type One and Type Two Diabetic Subjects during Induced Hypoglycemia
| Sponsor |
GlucoLight Corporation |
| Investigators |
Jeffrey Joseph, DO, Brian Hipszer, PhD, Intekab Ahmed, MD, Jennifer Lessin, RN |
| Description |
Human clinical trial to evaluate a non-invasive glucose monitor during induced hypoglycemia in volunteer subjects with type 1 and type 2 diabetes. |
pH Sensitive Complex Hydrogels for Protein Drug Release
| Sponsor |
National Institutes of Health NIH/NIDDK (RO1GM43337-08A1) |
| Investigators |
Jeffrey Joseph, DO, Nicholas Peppas, PhD (Purdue University), Anthony Lowman, PhD (Drexel University) |
| Description |
Development and pharmacokinetic studies of novel hydrogel formulations for the controlled delivery of insulin from the GI tract into systemic circulation were conducted. |
Blood Sample Acquisition From a Peripheral Venous Catheter: Comparing the Single-stopcock Method to the Venous Arterial Blood Management Protection System Method (Vamp Plus)
| Sponsor |
Anesthesiology Research and Education Fund at Thomas Jefferson University |
| Investigators |
Jeffrey Joseph, DO, Brian Hipszer, PhD, Boris Mraovic, MD, Zvi Grunwald, MD |
| Description |
Clinical trial in diabetic and non-diabetic volunteers to compare success of repeat blood sample acquisition from a stopcock or a VAMP system.
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Comparison of Glucose Levels in Simultaneous Samples of Arterial, Capillary, and Venous Blood
| Sponsor |
Anesthesiology Research and Education Fund at Thomas Jefferson University |
| Investigators |
Jeffrey Joseph, DO, Jeremy Flood, MD, Larry Kim, MD, Brian Hipszer, PhD, Steven McNulty, DO, Inna Chervoneva, PhD, James Diehl, MD, Scott Silvestry, MD |
| Description |
The glucose concentration of blood simultaneous sampled from a radial artery catheter, central venous catheter, and capillary fingerstick were compared using an Accu-Chek glucose meter and strips.
|
Development and Testing of an Implantable Near-infrared Blood Glucose Sensor
| Sponsor |
Animas Corporation |
| Investigators |
Jeffrey Joseph, DO, Marc Torjman, PhD, Barry Goldstein, MD, PhD, Brian Hipszer, PhD, Michael Moritz, MD, Peter McCue, MD, Ronald Jensh, PhD , Paul Dimusio, MD, Neils Martin, MD |
| Description |
Laboratory, human blood, and animal studies to develop and test a long-term implantable near-infrared blood glucose monitoring system. |
Artificial Pancreas for Control of Blood Glucose and Insulin Levels in Hospitalized Patients with Diabetes and Stress Hyperglycemia
| Sponsor |
Department of Defense: Technology for Metabolic Monitoring Program |
| Investigators |
Jeffrey Joseph, DO, Brian Hipszer, PhD, Zvi Grunwald, MD, Charles Yeo, MD, David Gratch, DO, James Heitz, MD, David Maguire, MD, Barry Goldstein, MD |
| Description |
Intravenous and interstitial fluid glucose sensors developed by Medtronic Inc. were evaluated in ten patients hospitalized for major surgery. One intravenous sensor and six interstitial fluid sensors were evaluated in each patient for 60 hours and compared to reference blood glucose measurements. |
An Implantable Near-IR Glucose Sensor
| Sponsor |
National Institutes of Health NIH/NIDDK (R01-DK55246-01) |
| Investigators |
Jeffrey Joseph, DO, Katherine Crothall, PhD (Animas Corporation), Marc Torjman, PhD, Barry Goldstein, MD, PhD, Michael Moritz, MD, Paul Dimusio, MD, Neils Martin, MD, Patrick Schaner, MD, Brian Hipszer, PhD, Maxim Soloviev, MD, PhD, Mark Destephano, Luis Jahn, PhD, Yizhong Yu, PhD |
| Description |
Development and testing of an implantable optical blood glucose monitoring system in diabetic humans and diabetic animals. |
Long-term Implantable Optical Blood Glucose Monitor
| Sponsor |
National Institute of Standards and Technology (NIST) Advanced Technology Award |
| Investigators |
Jeffrey Joseph, DO, Mark Destephano (Animas Corporation), Marc Torjman, PhD, Barry Goldstein, MD, PhD, Brian Hipszer, PhD, Paul Dimusio, MD, Katherine Crothall, PhD, Luis Jahn, PhD, Yizhong Yu, PhD |
| Description |
Development and testing of a long-term implantable intravascular optical blood glucose sensor in animals and humans. |
Retrospective Review of Blood Glucose Level and Patient Outcome following Total Knee and Hip Replacement Surgery
| Sponsor |
Lifescan Inc., a Johnson and Johnson Company |
| Investigators |
Jeffrey Joseph, DO, Boris Mraovic, MD, Zvi Grunwald, MD, Inna Chervoneva, PhD, Javid Parvizi, MD, Richard Rothman, MD, Brian Hipszer, PhD |
| Description |
Retrospective review of the TJU Hospital database and orthopedic surgery database to determine whether there is a correlation between glucose control and infection, other adverse events and mortality in patients undergoing total knee/hip replacement therapy. Analysis reviewed a correlation between pre-operative hyperglycemia and mortality, length of stay, and incidence of pulmonary embolism. |
Blood Glucose Level Determination Based on Intracardiac Electrogram Signals
| Sponsor |
St. Jude Medical Corporation |
| Investigators |
Jeffrey Joseph, DO, Brian Hipszer, PhD, Arnold Greenspon, MD, and David Maguire, MD |
| Description |
A human clinical trial was performed to determine whether intracardiac pacemaker and surface electrogram signals could be used to detect the onset of hypoglycemia. An algorithm was developed to detect hypoglycemia based upon changes in the pacemaker’s electrogram signal. |
Determination of Radial Artery Catheter Failure Modes using Ultrasound and Physical Examination
| Sponsor |
Anesthesiology Research and Education Fund at Thomas Jefferson University |
| Investigators |
Vincent Franze, DO, Jeffrey Joseph, DO, Dejan Vuckovic, MD, David Gratch, DO, Zvi Grunwald, MD, Boris Mraovic, MD, and Larry Needleman, MD |
| Description |
Hospital clinical trial using color-flow ultrasound to evaluate radial artery anatomy and blood flow before and after insertion of a radial artery catheter. |
Capillary Interface Drug Delivery Device- Implantable Catheter for Controlled Insulin Delivery- “CID3”
| Sponsor |
Anesthesiology Research and Education Fund at Thomas Jefferson University |
| Investigators |
Jeffrey Joseph, DO, Marc Torjman, PhD, Anita Mohandas, Brian Hipszer, PhD, A Shapiro, PhD, Anthony Lowman, PhD |
| Description |
Development of a long-term implantable insulin delivery catheter that utilizes tissue engineering techniques to grow and maintain a high density capillary network adjacent to the site of drug delivery (CID3- capillary interface drug delivery device). Insulin is rapidly and completely absorbed from the CID3, providing precise on-off control of plasma insulin levels. |
Implantable Arterial Tonometer to Continuously Monitor the Arterial Pressure Waveform in Ambulatory Humans
| Sponsor |
Anesthesiology Research and Education Fund at Thomas Jefferson University |
| Investigators |
Jeffrey Joseph DO, Brian Hipszer, PhD, Stephen McNulty, DO, Ryzard Lec, PhD, Mareck Swoboda, PhD |
| Description |
Development of a long-term implantable sensor (tonometer) that couples an array of force transducers to the outside wall of a small artery- to measure the blood pressure waveform with each beat of the heart.
|
Evaluation of the VIA-GLU Monitor for Real-time Blood Glucose Monitoring
| Sponsor |
Metracor Corporation |
| Investigators |
Jeffrey Joseph, DO, Arjuan Ganesh, PhD, Brian Hipszer, PhD, Navdeep Loomba, MD, Marc Torjman, PhD |
| Description |
Evaluation of the VIA Blood Chemistry Monitor for Glucose in healthy and diabetic volunteers. |
A Comparison of Glycaemic Variability in CSII vs. MDI Treated Type 1 Diabetic Patients Using CGMS
| Sponsor |
Medtronic Inc |
| Investigators |
Barbara Simons, MD, Vanita Treat, MD, Cheryl Marco, RN, Daniel Rosenberg, MD, Jeffrey Joseph, DO, Brian Hipszer, PhD, Y Li, MD, Inna Chervoneva, PhD, L Padron-Massara, MD, Serge Jabbour, MD |
| Description |
Evaluation of glucose variability using a continuous glucose monitoring system in T1DM patients managed with CSII or MDI |
Diurnal variation of the human adipose transcriptome and the link to metabolic disease
| Sponsor |
Merck, Inc. |
| Investigators |
Loboda A, Kraft W, Fine B, Joseph J, Nebozhyn M, Zang C, He, Xia Yang Y, Wright C, Morris M, Chalikonda I, Ferguson M, Emilsson V, Leonardson, Lamb J, Dai H, Schadt E, Greenberg H, Yee Lum |
| Description |
Adipose tissue was removed from human volunteers before and after oral diabetes medication to determine the effects of drug timing on transcription and translations |
