Research has long been an important part of surgical training at Jefferson. Current available laboratory space for research encompasses 4,900 square feet that includes a large animal operating room and tissue-culture facilities.

Projects in basic science and clinical research have included establishing ECMO capabilities at Jefferson to support critically ill neonates, developing hepatic resection and transplantation techniques, evaluating pancreatic islet-cell xenografting, exploring hyperthermia in cancer treatment and examining endothelial-cell, prosthetic-graft interactions.

The diverse interests of Jefferson's faculty allow for a multitude of cross-specialty protocols. Recent clinical research includes studies of multimodality therapy in pancreatic and colorectal carcinoma, preoperative chemotherapy in locally advanced breast carcinoma and the incidence and prevention of deep-vein thrombosis.