Philadelphia University + Thomas Jefferson University

Hajnoczky, Gyorgy

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Gyorgy Hajnoczky, MD, PhD

Gyorgy Hajnoczky, MD, PhD

Contact Dr. Hajnoczky

1020 Locust Street
527 Alumni Hall
Philadelphia, PA 19107

(215) 503-1427

Medical School

MD, Semmelweis University, Budapest - 1987
PhD, Semmelweis University, Budapest - 1987
National Academy of Sciences, Hungary - 1995

University Appointment

Raphael Rubin, MD Professor, Department of Pathology, Anatomy & Cell Biology

Research and Clinical Interests

Intracellular calcium signaling; inositol trisphosphate-linked hormones; organization of calcium mobilization from endoplasmic/sarcoplasmic reticulum; mitochondrial calcium signaling; calcium-dependent control over life and death of cells; fluorometric, fluorescence microscope imaging and electrophysiological approaches.

Signaling, calcium, ER, mitochondria, metabolism, apoptosis, imaging

Publications

Most Recent Peer-Reviewed Publications

  1. Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
  2. Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions
  3. Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018
  4. ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak
  5. Mitochondrial Nanotunnels
  6. Recessive mutations in MSTO1 cause mitochondrial dynamics impairment, leading to myopathy and ataxia
  7. MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans
  8. Intracellular Ca2+Sensing: Its Role in Calcium Homeostasis and Signaling
  9. Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU
  10. Natural and induced mitochondrial phosphate carrier loss: Differential dependence of mitochondrial metabolism and dynamics and cell survival on the extent of depletion
  11. VDAC2-specific cellular functions and the underlying structure
  12. Subcellular ROS imaging methods: Relevance for the study of calcium signaling
  13. Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface
  14. MICU1 regulation of mitochondrial Ca 2+ uptake dictates survival and tissue regeneration
  15. Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis
  16. The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease
  17. Trans-mitochondrial coordination of cristae at regulated membrane junctions
  18. Mitochondrial ca2+uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity
  19. Erratum: MCUR1 is an essential component of mitochondrial Ca2+uptake that regulates cellular metabolism (Nat. Cell Biol. 14, 2012 (1336-1343))
  20. Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015