Philadelphia University + Thomas Jefferson University

Hajnoczky, Gyorgy

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Gyorgy Hajnoczky, MD, PhD

Gyorgy Hajnoczky, MD, PhD

Contact Dr. Hajnoczky

1020 Locust Street
527 Alumni Hall
Philadelphia, PA 19107

(215) 503-1427

Medical School

MD, Semmelweis University, Budapest - 1987
PhD, Semmelweis University, Budapest - 1987
National Academy of Sciences, Hungary - 1995

University Appointment

Raphael Rubin, MD Professor, Department of Pathology, Anatomy & Cell Biology

Research and Clinical Interests

Intracellular calcium signaling; inositol trisphosphate-linked hormones; organization of calcium mobilization from endoplasmic/sarcoplasmic reticulum; mitochondrial calcium signaling; calcium-dependent control over life and death of cells; fluorometric, fluorescence microscope imaging and electrophysiological approaches.

Signaling, calcium, ER, mitochondria, metabolism, apoptosis, imaging

Publications

Most Recent Peer-Reviewed Publications

  1. MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360
  2. Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells
  3. MICU1 Confers Protection from MCU-Dependent Manganese Toxicity
  4. Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism
  5. Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
  6. Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions
  7. Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018
  8. ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak
  9. Mitochondrial Nanotunnels
  10. Recessive mutations in MSTO1 cause mitochondrial dynamics impairment, leading to myopathy and ataxia
  11. MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans
  12. Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling
  13. Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU
  14. Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges
  15. Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity
  16. Natural and induced mitochondrial phosphate carrier loss: Differential dependence of mitochondrial metabolism and dynamics and cell survival on the extent of depletion
  17. VDAC2-specific cellular functions and the underlying structure
  18. Subcellular ROS imaging methods: Relevance for the study of calcium signaling
  19. Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface
  20. MICU1 regulation of mitochondrial Ca 2+ uptake dictates survival and tissue regeneration