Philadelphia University + Thomas Jefferson University

Hajnoczky, Gyorgy

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Gyorgy Hajnoczky, MD, PhD

Gyorgy Hajnoczky, MD, PhD

Contact Dr. Hajnoczky

1020 Locust Street
527 Alumni Hall
Philadelphia, PA 19107

(215) 503-1427

Medical School

MD, Semmelweis University, Budapest - 1987
PhD, Semmelweis University, Budapest - 1987
National Academy of Sciences, Hungary - 1995

University Appointment

Raphael Rubin, MD Professor, Department of Pathology, Anatomy & Cell Biology

Research and Clinical Interests

Intracellular calcium signaling; inositol trisphosphate-linked hormones; organization of calcium mobilization from endoplasmic/sarcoplasmic reticulum; mitochondrial calcium signaling; calcium-dependent control over life and death of cells; fluorometric, fluorescence microscope imaging and electrophysiological approaches.

Signaling, calcium, ER, mitochondria, metabolism, apoptosis, imaging

Publications

Most Recent Peer-Reviewed Publications

  1. Coming together to define membrane contact sites
  2. Redox regulation of ER and mitochondrial Ca 2+ signaling in cell survival and death
  3. MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca 2+ Flux and Sensitivity to Ru360
  4. Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells
  5. MICU1 Confers Protection from MCU-Dependent Manganese Toxicity
  6. Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism
  7. Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
  8. Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions
  9. Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018
  10. ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak
  11. Mitochondrial Nanotunnels
  12. Recessive mutations in MSTO1 cause mitochondrial dynamics impairment, leading to myopathy and ataxia
  13. MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans
  14. Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling
  15. Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU
  16. Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges
  17. Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity
  18. Natural and induced mitochondrial phosphate carrier loss: Differential dependence of mitochondrial metabolism and dynamics and cell survival on the extent of depletion
  19. VDAC2-specific cellular functions and the underlying structure
  20. Subcellular ROS imaging methods: Relevance for the study of calcium signaling