Philadelphia University + Thomas Jefferson University

Summer, Ross

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Ross Summer, MD

Contact Dr. Summer

834 Walnut Street
Suite 650
Philadelphia, PA 19107

(215) 503-3893
(215) 955-0830 fax

Research and Clinical Interests

Dr Summer's laboratory focuses on lung metabolism and understanding how local and systemic metabolic derangements contribute to the onset and progression of lung diseases.

One major area of investigation is on the relationship between obesity and acute lung injury. Recent epidemiological studies indicate that a paradoxical relationship exists between obesity and acute lung injury, in that, obese individuals are at increased risk for developing acute lung injury but outcomes in established disease are improved when compared to lean patients. In these investigations, Dr Summer's laboratory is utilizing genetic and diet-induced obesity models to understand how injury and inflammatory responses differ during obesity. These studies aim to direct future clinical investigations focusing on the prevention and the treatment of acute lung injury in lean and obese subjects.

In related studies, Dr Summer's laboratory is investigating the association between hormonal responses from adipose tissue and outcomes in acute lung injury. It is now increasingly apparent that adipose tissue is not just a storage depot for fuel but an important endocrine organ that secretes a multitude of hormones called adipokines. These adipokines act on virtually all tissues, including lung, and serve to regulate diverse biological processes involved in immune, metabolic and vascular regulation. Recent work from Dr Summer's laboratory has identified a relationship between plasma levels of the adipokine adiponectin and outcomes in patients with respiratory failure from diverse etiologies. In ongoing investigations, his laboratory will investigate whether a similar association exists in patients with respiratory failure from acute lung injury. Adiponectin oligomeric fractions will be measured in plasma samples obtained from patients participating in the National Heart, Lung and Blood Institute ARDS Network Fluid and Catheter Treatment Trial (FACTT). The goal of this study is determine whether measuring adiponectin oligomers is useful for predicting outcomes in patients with acute lung injury

Another major focus of Dr Summer's laboratory is on intermediary metabolism in the lung and understanding how alterations in local metabolic activity contribute to the progression of lung diseases. Our current hypothesis is that metabolic stress resulting from lung injury drives the inflammatory and the reparative responses seen in many pathological lung conditions (e.g. idiopathic pulmonary fibrosis, sarcoidosis, hypersensitivity pneumonitis, acute lung injury). The goal of these studies is to identify novel therapeutic targets of metabolic pathways that can be used for treating lung diseases.

Publications

Most Recent Peer-Reviewed Publications

  1. Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust
  2. The involvement of GM-CSF deficiencies in parallel pathways of pulmonary alveolar proteinosis and the alcoholic lung
  3. Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome
  4. Time to personalize the treatment of anti-MDA-5 associated lung disease
  5. Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium
  6. Metabolic Reprogramming as a Driver of Fibroblast Activation in PulmonaryFibrosis
  7. Proteomic profile of TGF-β1 treated lung fibroblasts identifies novel markers of activated fibroblasts in the silica exposed rat lung
  8. Cellular Metabolism in Lung Health and Disease
  9. Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis
  10. Combination of biochanin a and temozolomide impairs tumor growth by modulating cell metabolism in glioblastoma multiforme
  11. Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice
  12. Lipid synthesis is required to resolve endoplasmic reticulum stress and limit fibrotic responses in the lung
  13. Silicosis decreases bone mineral density in rats
  14. Severe airflow obstruction in a man with stomatitis and lymphadenopathy
  15. Muc1 deficiency exacerbates pulmonary fibrosis in a mouse model of silicosis
  16. Protein folding and the challenges of maintaining endoplasmic reticulum proteostasis in idiopathic pulmonary fibrosis
  17. Target-Specific Delivery of an Antibody That Blocks the Formation of Collagen Deposits in Skin and Lung
  18. Obesity-induced endoplasmic reticulum stress causes lung endothelial dysfunction and promotes acute lung injury
  19. An official American thoracic society workshop report: Obesity and metabolism an emerging frontier in lung health and disease
  20. Binding of CIB1 to the aIIb tail of aIIbβ3 is required for FAK recruitment and activation in platelets