Philadelphia University + Thomas Jefferson University

Iozzo, Renato V.

< Back



Renato V. Iozzo, MD

Contact Dr. Iozzo

1020 Locust Street
336 Alumni Hall
Philadelphia, PA 19107

(215) 503-2208
(215) 923-7969 fax

Medical School

MD, Florence, University of Florence School of Medicine (Summa Cum Laude ), Italy
Medical Licensure (Active), Commonwealth of Pennsylvania
Medical Licensure (Active), Washington State


Anatomic Pathology Residency, University of Washington, Seattle WA


NIH Post-Doctoral Fellowship, University of Washington, Seattle WA

Board Certification

Board Certification, American Board of Pathology

University Appointment

The Gonzalo E. Aponte Professor of Pathology, Anatomy, & Cell Biology 
Deputy Chair, Department of Pathology, Anatomy & Cell Biology 
Professor of Biochemistry and Molecular Biology (Secondary) 
Director, Electron Microscopy, Thomas Jefferson University Hospital

Research and Clinical Interests

Professor of Pathology and Cell Biology, and Director of the Extracellular Matrix Program at the Kimmel Cancer Center, Thomas Jefferson University. After receiving an M.D. degree summa cum laude from the University of Florence, Italy, he moved to the Department of Pathology at the University of Washington, where he completed a five-year Residency/Fellowship. Following a six-year faculty appointment at the University of Pennsylvania, he moved to Thomas Jefferson University. Dr. Iozzo has received many awards including the Benjamin Castleman Award from the International Academy of Pathology, the Junior Faculty Research Award from the American Cancer Society, the Burlington Resources Foundation Faculty Achievement Award, and the Faculty Research Award from the American Cancer Society. In 2008, Dr. Iozzo received an Honorary Professorship at the School of Life Sciences, University of Manchester, UK. His research focuses on the biology of proteoglycans and their roles in cancer and angiogenesis.

Other Expertise


At University of Pennsylvania
1983-1988 Member, Service Center Review Committee
1985-1988 Member, Medical School Admission Committee
1988 Member, Committee for Reviewing Cardiovascular Teaching

At Thomas Jefferson University
1989-1999 Member, Admission Committee for Gibbon Scholar, M.D./Ph.D. Program
1989-2000 Member, Career Planning Program Committee, Department of Pathology
1991-present Member, Kimmel Cancer Institute
1991-2001 Member, Pathology Residency Review Committee, Department of Pathology
1993-1997 Member, Committee on Research, Jefferson Medical College
1994-1997 Chairman, Subcommittee on Award Nomination, Committee on Research
1995-2005 Member, Curriculum Committee, Department of Pathology
1996-1999 Advisory Committee of the Professorial Faculty, Jefferson Medical College
2002-2006 Member, Committee on Students Affairs, Thomas Jefferson University
2005-2006 Member, Cancer Biology Strategic Plan Committee, Kimmel cancer Center
2005-2006 Member, Bone and Matrix Biology Strategic Plan Committee, Thomas Jefferson University
2009- Member Executive Committee, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University
2010- Member, Executive Committee, Kimmel Cancer Center, Thomas Jefferson University

2005 Invited Speaker, University of Delaware, Wilmington, DE
2005 Invited Speaker, Symposium in honor of Robert Rosenberg, MIT, Boston
2005 Chair and Speaker, Symposium on Extracellular Matrix Regulation of Angiogenesis Co-sponsored by ASIP and ASMB, Experimental Biology Meeting, San Diego, CA
2005 Invited Speaker, International Symposium on Proteoglycans in Signaling, Stockholm, Sweden
2005 Visiting Professor, Medical College of Wisconsin, Milwaukee, WI
2005 Invited Speaker, 13th Symposium on Glycosaminoglycans, Lake Como, Italy
2005 Invited Speaker, 18th International Symposium on Glycoconjugates, Florence, Italy
2005 Co-organizer and Session Chair, 12th International Symposium on Basement Membranes, Philadelphia, PA
2005 Visiting Professor, Darthmouth Medical School, Hannover, NH
2005 Visiting Professor, Boston University Medical School, Boston, MA
2005 Visiting Professor, Vanderbilt University Medical Center, Nashville, TN
2006 Visiting Professor, Case Western Reserve University School of Medicine, Cleveland, OH
2006 Visiting Professor, University of Alabama, Birmingham, AL
2006 Visiting Professor, McGill University, Montreal, Canada
2006 Session Chair and Speaker, International Symposium on Extracellular Glycomatrix in Health and Disease, Awaji, Japan
2006 Session Chair/Speaker, Gordon Research Conference on Basement Membranes, Il Ciocco, Italy
2006 Session Chair and Speaker, Gordon Research Conference on Proteoglycans, Proctor Academy, NH
2006 Invited Speaker, Priority Research Program on Basement Membranes, Freiburg, Germany
2006 Session Chair, 3rd annual meeting, American Society for Matrix Biology, Nashville, TN
2007 Visiting Professor, Harvard School of Dental Medicine, Boston, MA
2007 Visiting Professor, University of Alabama at Birmingham, AL
2007 Session Chair, International Conference on Proteoglycans, Rio De Janeiro, Brazil
2007 Invited speaker, Pan-Pacific Connective Tissue Society Meeting, Cairns, Australia
2008 Invited Speaker, Gordon Research Conference on Basement Membranes, Bidderford, ME
2008 Session Chair, Gordon Research Conference on Proteoglycans, Proctor Academy, NH
2008 Invited Speaker, International Conference of Cell Biology, Seoul, South Korea
2008 Chair, Biennial Meeting of the American Society for Matrix Biology, San Diego, CA
2009 Keynote Speaker, Hellenic Society for Matrix Biology, Patras, Greece
2009 Plenary Speaker, FEBS Advance Lecture Course on Matrix Pathobiology, Patras, Greece
2009 Invited Speaker, 6th International Conference on Proteoglycans, Aix les Bains, France
2009 Invited Speaker, Klenk Symposium on Molecular Medicine, Cologne, Germany
2009 Invited Speaker, Annual Meeting of the Society for Glycobiology, San Diego, CA
2010 Visiting Professor, University of Pennsylvania, Philadelphia, PA

2010 Visiting Professor, University of Pittsburgh, Pittsburgh, PA
2010 Keynote Speaker, German and British Society for Matrix Biology, Frankfurt, Germany
2010 Visiting Professor, University of Georgia, Athens, GA
2010 Plenary Speaker and Session Chair, XXII FECTS Meeting, Davos, Switzerland
2010 Visiting Professor, University of Zurich, Zurich, Switzerland
2010 Session Chair and Member of the Organizing Committee, Gordon Research Conference on Proteoglycans, Proctor Academy, NH
2010 Session Chair and Member of the Organizing Committee, Biennial Meeting of the American Society for Matrix Biology, Charleston, SC
2010 Visiting Professor, Washington University, St. Louis, MO
2010 Visiting Professor, Harvard School of Dental Medicine, Boston, MA
2010 Visiting Professor, University of Florence school of Medicine, Florence, Italy
2011 Invited Speaker, Symposium in honor of Bjorn Olsen, Harvard Medical School, Boston, MA
2011 Plenary Speaker, FEBS Advance Lecture Course on Matrix Pathobiology, Spetses, Greece
2011 Keynote Speaker, Australia and New Zealand Matrix Biology Society Meeting, Sydney, Australia


1986- Ad Hoc reviewer: Netherlands Cancer Foundation; Pathobiochemistry Study Section, NIH; Cell Biology Study Section, NIH; Pathology A, Study Section, NIH; Reviewer, Medical Research Council of Canada; Veterans Administration, National Science Foundation
1991 Member, Site Visit Team, National Heart and Lung and Blood Institute
1992 Ad hoc Reviewer, Pathobiochemistry Study Section, NIH
1993 Member, External Review Committee for the Department of Biochemistry, American Red Cross, Holland Laboratories, Rockville, MA
2000 Special Reviewer, Pathobiochemistry Study Section
2002- Member, NIH Special Emphasis Review Panel (ZRG1 BIO)
2003 Tumor Microenvironment Study Section, NIH
2006-08 Special Emphasis Panel Reviewer, NIHLB, NIH
2008 Member, External Review Panel for Molecular Biology Section, NIDCR, NIH
2009 Special Emphasis Panel/Scientific Review Group 2010/01 HLBP
2009 Special Emphasis Panel/Scientific Review Group 2010/01 ZRG1 OTC-D
2010- Member of the College of CSR Reviewers, NIH


Most Recent Peer-Reviewed Publications

  1. Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke
  2. Dual regulation of decorin by androgen and Hedgehog signaling during prostate morphogenesis
  3. Extracellular matrix: The driving force of mammalian diseases
  4. Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors
  5. The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin
  6. The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis
  7. Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium
  8. Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons
  9. A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia
  10. Steroid hormones are key modulators of tissue mechanical function via regulation of collagen and elastic fibers
  11. Decorin-inducible Peg3 evokes beclin 1-mediated autophagy and thrombospondin 1-mediated angiostasis
  12. Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin
  13. Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy
  14. Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology
  15. The nature and biology of basement membranes
  16. A current view of perlecan in physiology and pathology: A mosaic of functions
  17. Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy
  18. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes
  19. Oncogenic activin C interacts with decorin in colorectal cancer in vivo and in vitro
  20. Glycoproteomics Reveals Decorin Peptides with Anti-Myostatin Activity in Human Atrial Fibrillation