Philadelphia University + Thomas Jefferson University

Smeyne, Richard

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Richard J. Smeyne, PhD

Richard J. Smeyne, PhD

Contact Dr. Smeyne

233 South Ninth Street
Philadelphia, PA 19107

(215) 955-8634

Research and Clinical Interests

Cell Biology of Parkinson’s Disease


Most Recent Peer-Reviewed Publications

  1. Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling
  2. Assessment of the effects of MPTP and paraquat on dopaminergic neurons and microglia in the substantia nigra pars compacta of C57BL/6 mice
  3. Erratum: Bacterial Peptidoglycan Traverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior (Cell Host and Microbe (2016) 19 (388399))
  4. Bacterial Peptidoglycan Transverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior
  5. HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta
  6. Induction of microglia activation after infection with the non-neurotropic A/CA/04/2009 H1N1 influenza virus
  7. SCYL2 protects CA3 pyramidal neurons from excitotoxicity during functional maturation of the mouse hippocampus
  8. P75 Regulates Purkinje cell firing by modulating SK channel activity through Rac1
  9. From Man to Mouse: The MPTP Model of Parkinson Disease
  10. Neurochemical measurement of adenosine in discrete brain regions of five strains of inbred mice
  11. Exercise: Is it a neuroprotective and if so, how does it work?
  12. Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models
  13. Immunologic privilege in the central nervous system and the blood-brain barrier
  14. Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease
  15. Exercise does not protect against MPTP-induced neurotoxicity in BDNF happloinsufficent mice
  16. Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice
  17. Long-lasting transcriptional refractoriness triggered by a single exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine
  18. Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice
  19. Inflammatory effects of highly pathogenic H5N1 influenza virus infection in the CNS of mice
  20. Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta