Philadelphia University + Thomas Jefferson University

Sperling, Michael R

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Michael R. Sperling, MD

Contact Dr. Sperling

900 Walnut Street
JHN 4th floor
Philadelphia, PA 19107

(215) 955-1222
(215) 503-4358 fax

Research and Clinical Interests

Clinical epilepsy, EEG

The research program in the Jefferson Comprehensive Epilepsy Center is multifaceted, reflecting the interests of the ten faculty members in the center. We are investigating various aspects of epilepsy, including novel treatments, autonomic effects of seizures, electrophysiology of seizures, new approaches to neuroimaging, and developing improved methods of prognostication in epilepsy. Pharmacologic studies investigate the metabolic consequences of antiepileptic medication, with specific attention to serologic markers of vascular risk. Neuroimaging studies are exploring connections between different brain areas in epilepsy, cognitive organization, memory, and language function in epilepsy. Electrographic studies of seizures hope to improve methods for mapping seizure spread within the brain with the goal of defining abnormal circuitry in epilepsy. Autonomic studies investigate cardiac rhythm disturbances in epilepsy, with companion epidemiologic studies of mortality in epilepsy. Long-term outcome studies of epilepsy surgery explore the consequences of cortical resection for this condition in medical, cognitive, linguistic, and psychosocial domains.

The techniques used in our research are those used in clinical studies, including MRI, fMRI, EEG, metabolic and pharmacologic measures, and epidemiologic methods.


Most Recent Peer-Reviewed Publications

  1. Closed-loop stimulation of temporal cortex rescues functional networks and improves memory
  2. Presurgical depression and anxiety are not associated with worse epilepsy surgery outcome five years postoperatively
  3. Epileptologist's view: Laser interstitial thermal ablation for treatment of temporal lobe epilepsy
  4. Disrupted dynamic network reconfiguration of the language system in temporal lobe epilepsy
  5. Common data elements for epilepsy mobile health systems
  6. Task activation and functional connectivity show concordant memory laterality in temporal lobe epilepsy
  7. Automated trajectory planning for laser interstitial thermal therapy in mesial temporal lobe epilepsy
  8. Evidence for verbal memory enhancement with electrical brain stimulation in the lateral temporal cortex
  9. Electrophysiological signatures of spatial boundaries in the human subiculum
  10. Increased neuronal synchrony prepares mesial temporal networks for seizures of neocortical origin
  11. Efficacy and safety of eslicarbazepine acetate monotherapy in patients converting from carbamazepine
  12. Long-term surveillance of SUDEP in drug-resistant epilepsy patients treated with VNS therapy
  13. A method for the topographical identification and quantification of high frequency oscillations in intracranial electroencephalography recordings
  14. Utilization of independent component analysis for accurate pathological ripple detection in intracranial EEG recordings recorded extra- and intra-operatively
  15. Electrical stimulation modulates high γ activity and human memory performance
  16. Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition
  17. Erratum to “Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study” (Epilepsy Res. (2017) 131 (70–75) (S0920121116302789) (10.1016/j.eplepsyres.2017.02.007))
  18. Bimodal coupling of ripples and slower oscillations during sleep in patients with focal epilepsy
  19. Detection of generalized tonic–clonic seizures using surface electromyographic monitoring
  20. Atlas of Electroencephalography, 3rd Edition